Search Results - "Wainwright, B"

The biomechanics of maintaining effective force application across cycling positions by Jongerius, N., Wainwright, B., Walker, J., Bissas, A.

“…Cyclists are known to change their cycling position to reduce aerodynamic drag. Research has shown that this compromises their physical capacity to perform,…”
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A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma by Conduit, S E, Ramaswamy, V, Remke, M, Watkins, D N, Wainwright, B J, Taylor, M D, Mitchell, C A, Dyson, J M

“…Sonic Hedgehog (SHH) signaling at primary cilia drives the proliferation and progression of a subset of medulloblastomas, the most common malignant paediatric…”
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Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling by Ingram, W J, McCue, K I, Tran, T H, Hallahan, A R, Wainwright, B J

“…Aberrant regulation of signalling mechanisms that normally orchestrate embryonic development, such as the Hedgehog, Wnt and Notch pathways, is a common feature…”
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Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation by Calao, M, Sekyere, E O, Cui, H J, Cheung, B B, Thomas, W D, Keating, J, Chen, J B, Raif, A, Jankowski, K, Davies, N P, Bekkum, M V, Chen, B, Tan, O, Ellis, T, Norris, M D, Haber, M, Kim, E S, Shohet, J M, Trahair, T N, Liu, T, Wainwright, B J, Ding, H F, Marshall, G M

“…Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations…”
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Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma by Julian, E, Dave, R K, Robson, J P, Hallahan, A R, Wainwright, B J

“…Current treatment for medulloblastoma is successful in more than half of all cases but results in substantial disability in survivors. Accordingly, there is…”
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Touchdown PCR to circumvent spurious priming during gene amplification by DON, R. H, COX, P. T, WAINWRIGHT, B. J, BAKER, K, MATTICK, J. S

“…We devised a simple solution taking advantage of the exponential nature of PCR reactions, and which begins at or above, rather than below, the expected…”
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Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression by Thomas, W D, Chen, J, Gao, Y R, Cheung, B, Koach, J, Sekyere, E, Norris, M D, Haber, M, Ellis, T, Wainwright, B, Marshall, G M

“…Medulloblastoma tumorigenesis caused by inactivating mutations in the PATCHED1 ( PTCH1 ) gene is initiated by persistently activated Sonic Hedgehog (Shh)…”
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High prevalence of Helicobacter pylori in the Alaska native population and association with low serum ferritin levels in young adults by Parkinson, A J, Gold, B D, Bulkow, L, Wainwright, R B, Swaminathan, B, Khanna, B, Petersen, K M, Fitzgerald, M A

“…Iron deficiency anemia is a common public health problem in the Alaska Native population. Yet, a clear etiology has eluded researchers for decades. Previous…”
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Protection Provided by Hepatitis B Vaccine in a Yupik Eskimo Population—Results of a 10-Year Study by Wainwright, Robert B., Bulkow, Lisa R., Parkinson, Alan J., Zanis, Carolyn, McMahon, Brian J.

“…A hepatitis B virus vaccine demonstration project was conducted in southwest Alaska in 1981–1982 to determine the immunogenicity and efficacy of the vaccine. A…”
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Elimination of New Chronic Hepatitis B Virus Infections: Results of the Alaska Immunization Program by Harpaz, Rafael, McMahon, Brian J., Margolis, Harold S., Shapiro, Craig N., Havron, Dean, Carpenter, Gina, Bulkow, Lisa R., Wainwright, Robert B.

“…An immunization assessment and a serologic survey were conducted to evaluate the effectiveness of a hepatitis B immunization program in eliminating hepatitis B…”
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Isolation and Characterization of Human Patched 2 (PTCH2), a Putative Tumour Suppressor Gene in Basal Cell Carcinoma and Medulloblastoma on Chromosome 1p32 by Smyth, Ian, Narang, Monica A., Evans, Tim, Heimann, Cornelia, Nakamura, Yusuke, Chenevix-Trench, Georgia, Pietsch, Torsten, Wicking, Carol, Wainwright, Brandon J.

“…Mutations of the human Patched gene (PTCH) have been identified in individuals with the nevoid basal cell carcinoma syndrome (NBCCS) as well as in sporadic…”
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Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises from Gene-Autonomous Transcriptional Probability of Individual Inducible Genes by Ravasi, Timothy, Wells, Christine, Forest, Alistair, Underhill, David M, Wainwright, Brandon J, Aderem, Alan, Grimmond, Sean, Hume, David A

“…Microbial products such as LPS stimulate macrophages to produce a wide diversity of inducible gene products needed for immediate host defense and priming of an…”
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Sendai virus-mediated CFTR gene transfer to the airway epithelium by FERRARI, S, GRIESENBACH, U, INOUE, M, CHAN, M, SINGH, C, VERDON, B, ARGENT, B. E, WAINWRIGHT, B, JEFFERY, P. K, GEDDES, D. M, PORTEOUS, D. J, HYDE, S. C, IIDA, A, GRAY, M. A, HASEGAWA, M, ALTON, E. W. F. W, FARLEY, R, WRIGHT, A. M, ZHU, J, MUNKONGE, F. M, SMITH, S. N, YOU, J, BAN, H

“…The potential for gene therapy to be an effective treatment for cystic fibrosis has been hampered by the limited gene transfer efficiency of current vectors…”
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Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium by FERRARI, S, KITSON, C, GEDDES, D. M, ALTON, Ewfw, FARLEY, R, STEEL, R, MARRIOTT, C, PARKINS, D. A, SCARPA, M, WAINWRIGHT, B, EVANS, M. J, COLLEDGE, W. H

“…Nonviral vectors have been shown to be a safe and valid alternative to recombinant viruses for gene therapy of cystic fibrosis (CF). Nevertheless, gene…”
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DHPLC Analysis of patients with Nevoid Basal Cell Carcinoma Syndrome reveals novel PTCH missense mutations in the sterol-sensing domain by Marsh, A., Wicking, C., Wainwright, B., Chenevix-Trench, G.

“…Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is an autosomal dominant disorder characterised by multiple basal cell carcinomas, palmar and plantar pitting,…”
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Effector ExoU from the Type III Secretion System Is an Important Modulator of Gene Expression in Lung Epithelial Cells in Response to Pseudomonas aeruginosa Infection by MCMORRAN, B, TOWN, L, COSTELLOE, E, PALMER, J, ENGEL, J, HUME, D, WAINWRIGHT, B

“…AUTHOR'S CORRECTION ( vol. 71 , p. 7240 ) Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction by Dorin, J R, Farley, R, Webb, S, Smith, S N, Farini, E, Delaney, S J, Wainwright, B J, Alton, E W, Porteous, D J

“…Quantifying the level of transgene expression necessary for phenotypic effect is an important consideration in designing somatic gene therapy protocols. A…”
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Attachment, Temperament, and Preschool Children's Peer Acceptance by Szewczyk-Sokolowski, Margaret, Bost, Kelly K., Wainwright, Ada B.

“…This study examined the relations between preschool children's attachment security, temperament, and peer acceptance. Ninety‐eight preschool children and their…”
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Malaria, intestinal parasites, and schistosomiasis among Barawan Somali refugees resettling to the United States: a strategy to reduce morbidity and decrease the risk of imported infections by Miller, J M, Boyd, H A, Ostrowski, S R, Cookson, S T, Parise, M E, Gonzaga, P S, Addiss, D G, Wilson, M, Nguyen-Dinh, P, Wahlquist, S P, Weld, L H, Wainwright, R B, Gushulak, B D, Cetron, M S

“…In 1997, enhanced health assessments were performed for 390 (10%) of approximately 4,000 Barawan refugees resettling to the United States. Of the refugees who…”
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G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease by McMorran, B J, Palmer, J S, Lunn, D P, Oceandy, D, Costelloe, E O, Thomas, G R, Hume, D A, Wainwright, B J

“…Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive…”
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