Search Results - "Wainscott, D B"

Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation by Johnson, K W, Nelson, D L, Dieckman, D K, Wainscott, D B, Lucaites, V L, Audia, J E, Owton, W M, Phebus, L A

“…The compound m-chlorophenylpiperazine (mCPP), which is known to trigger migraine-like head pain in some subjects, was evaluated for its ability to induce dural…”
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Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors by Nelson, D. L., Lucaites, V. L., Wainscott, D. B., Glennon, R. A.

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Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor by Wainscott, D B, Cohen, M L, Schenck, K W, Audia, J E, Nissen, J S, Baez, M, Kursar, J D, Lucaites, V L, Nelson, D L

“…The rat 5-hydroxytryptamine (5-HT)2F (serotonin2F) receptor is a newly cloned member of the 5-HT2/1C receptor family. The pharmacology of the 5-HT2F receptor…”
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Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus by Kursar, J D, Nelson, D L, Wainscott, D B, Cohen, M L, Baez, M

“…Using the polymerase chain reaction amplification technique in conjunction with conventional cloning techniques, we have isolated a novel member of the…”
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Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines by Nelson, D L, Lucaites, V L, Audia, J E, Nissen, J S, Wainscott, D B

“…Species differences in the recognition of a series of ergolines by the 5-hydroxytryptamine2 (5-HT2, serotonin2) receptor were investigated in four species, the…”
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Substituted Naphthofurans as Hallucinogenic Phenethylamine−Ergoline Hybrid Molecules with Unexpected Muscarinic Antagonist Activity by Monte, Aaron P, Marona-Lewicka, Danuta, Lewis, Mechelle M, Mailman, Richard B, Wainscott, David B, Nelson, David L, Nichols, David E

“…A series of substituted racemic naphthofurans were synthesized as “hybrid” molecules of the two major prototypical hallucinogenic drug classes, the…”
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Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor by Kursar, J D, Nelson, D L, Wainscott, D B, Baez, M

“…Clones encoding a portion of the human 5-hydroxytryptamine (5-HT)2B receptor gene were isolated from a human placental genomic library. Based on distribution…”
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Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences by Wainscott, D B, Lucaites, V L, Kursar, J D, Baez, M, Nelson, D L

“…The 5-Hydroxytryptamine2B (5-HT2B) receptor was cloned originally from rat stomach fundus and its pharmacology was determined to be consistent with that of the…”
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DOI and alpha-methylserotonin: comparative vascular and nonvascular smooth muscle effects and central 5-hydroxytryptamine2 receptor affinities by Cohen, M L, Johnson, M P, Schenck, K W, Susemichel, A, Wainscott, D B, Robertson, D W, Nelson, D L

“…Both alpha-methylserotonin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) are agonists at 5-hydroxytryptamine2 (5-HT2) receptors. The present study…”
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Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner by JOHNSON, M. P, WAINSCOTT, D. B, LUCAITES, V. L, BAEZ, M, NELSON, D. L

“…Two mutations of the rat serotonin 5-HT2A receptor were made, expressed and examined for their ability to bind and be stimulated by certain tryptamines as well…”
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The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine by Rasmussen, K, Calligaro, D O, Czachura, J F, Dreshfield-Ahmad, L J, Evans, D C, Hemrick-Luecke, S K, Kallman, M J, Kendrick, W T, Leander, J D, Nelson, D L, Overshiner, C D, Wainscott, D B, Wolff, M C, Wong, D T, Branchek, T A, Zgombick, J M, Xu, Y C

“…LY426965 [(2S)-(+)-1-cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]2-methyl- 2-phenyl-1-butanone monohydrochloride] is a novel compound with high affinity…”
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Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups by Monte, Aaron P, Marona-Lewicka, Danuta, Parker, Matthew A, Wainscott, David B, Nelson, David L, Nichols, David E

“…Tetrahydrobenzodifuran functionalities were employed as conformationally restricted bioisosteres of the aromatic methoxy groups in prototypical hallucinogenic…”
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Dihydrobenzofuran Analogues of Hallucinogens. 4. Mescaline Derivatives by Monte, Aaron P, Waldman, Steve R, Marona-Lewicka, Danuta, Wainscott, David B, Nelson, David L, Sanders-Bush, Elaine, Nichols, David E

“…Dihydrobenzofuran and tetrahydrobenzodifuran functionalities were employed as conformationally restricted bioisosteres of the aromatic methoxy groups in the…”
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Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily by Lucaites, V L, Nelson, D L, Wainscott, D B, Baez, M

“…The 5-Hydroxytryptamine (5-HT)2C receptor (originally known as the 5-HT1C receptor) is a member of the 5-HT2 subfamily of G protein coupled receptors, which is…”
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Human 5-HT1F receptor-stimulated [35S]GTPγS binding: correlation with inhibition of guinea pig dural plasma protein extravasation by WAINSCOTT, D. B, JOHNSON, K. W, PHEBUS, L. A, SCHAUS, J. M, NELSON, D. L

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Molecular Biology of Serotonin Receptors by Baez, Melvyn, Kursar, Jonathan D., Helton, Lisa A., Wainscott, David B., Nelson, David L.G.

“…Over the last several years the use of molecular cloning technology has revealed a vast diversity among serotonin (5‐HT)receptors, where by what was previously…”
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A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines by Bryant, H U, Nelson, D L, Button, D, Cole, H W, Baez, M B, Lucaites, V L, Wainscott, D B, Whitesitt, C, Reel, J, Simon, R, Koppel, G A

“…Local delivery of serotonin (5-HT) produces a rapid edematous response in soft tissues via increased fluid extravasation which is prevented by 5-HT2…”
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Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation by Wainscott, D B, Johnson, K W, Phebus, L A, Schaus, J M, Nelson, D L

“…To determine the potency and efficacy of 5-HT1F receptor ligands, a [35S]GTPgammaS binding assay was developed and optimized for the human 5-HT1F receptor…”
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Advances toward new antidepressants beyond SSRIS: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4 by ROCCO, Vincent P, SPINAZZE, Patrick G, TAKEUCHI, Kumiko, KOHN, Todd J, HONIGSCHMIDT, Nicholas A, NELSON, David L, WAINSCOTT, D. Bradley, AHMAD, Laura J, SHAW, Janice, THRELKELD, Penny G, WONG, David T

“…A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was…”
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Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors by Nelson, D L, Lucaites, V L, Wainscott, D B, Glennon, R A

“…Since the classical hallucinogens were initially reported to produce their behavioral effects via a 5-HT2 agonist mechanism (i.e., the 5-HT2 hypothesis of…”
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