Search Results - "Wainman, Alan"

SAPs as a new model to probe the pathway of centriole and centrosome assembly by Wainman, Alan

“…Centrioles are important cellular organelles involved in the formation of both cilia and centrosomes. It is therefore not surprising that their dysfunction may…”
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Centrosome function and assembly in animal cells by Conduit, Paul T., Wainman, Alan, Raff, Jordan W.

“…Key Points Centrosomes are not essential for cell division in most animal cells, although they contribute to the efficiency of mitotic spindle assembly…”
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Structural Basis for Mitotic Centrosome Assembly in Flies by Feng, Zhe, Caballe, Anna, Wainman, Alan, Johnson, Steven, Haensele, Andreas F.M., Cottee, Matthew A., Conduit, Paul T., Lea, Susan M., Raff, Jordan W.

“…In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold…”
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Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes by Novak, Zsofia A., Wainman, Alan, Gartenmann, Lisa, Raff, Jordan W.

“…Centrosomes and cilia are organized by a centriole pair comprising an older mother and a younger daughter. Centriole numbers are tightly regulated, and…”
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A homeostatic clock sets daughter centriole size in flies by Aydogan, Mustafa G, Wainman, Alan, Saurya, Saroj, Steinacker, Thomas L, Caballe, Anna, Novak, Zsofia A, Baumbach, Janina, Muschalik, Nadine, Raff, Jordan W

“…Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4…”
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The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation by Conduit, Paul T., Feng, Zhe, Richens, Jennifer H., Baumbach, Janina, Wainman, Alan, Bakshi, Suruchi D., Dobbelaere, Jeroen, Johnson, Steven, Lea, Susan M., Raff, Jordan W.

“…Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during…”
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Cell cycle dependent coordination of surface layer biogenesis in Caulobacter crescentus by Herdman, Matthew, Isbilir, Buse, von Kügelgen, Andriko, Schulze, Ulrike, Wainman, Alan, Bharat, Tanmay A. M.

“…Surface layers (S-layers) are proteinaceous, two-dimensional paracrystalline arrays that constitute a major component of the cell envelope in many prokaryotic…”
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Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences by Lee, Jeffrey Y, Wing, Peter A C, Gala, Dalia S, Noerenberg, Marko, Järvelin, Aino I, Titlow, Joshua, Zhuang, Xiaodong, Palmalux, Natasha, Iselin, Louisa, Thompson, Mary Kay, Parton, Richard M, Prange-Barczynska, Maria, Wainman, Alan, Salguero, Francisco J, Bishop, Tammie, Agranoff, Daniel, James, William, Castello, Alfredo, McKeating, Jane A, Davis, Ilan

“…Despite an unprecedented global research effort on SARS-CoV-2, early replication events remain poorly understood. Given the clinical importance of emergent…”
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Evidence that a positive feedback loop drives centrosome maturation in fly embryos by Alvarez-Rodrigo, Ines, Steinacker, Thomas L, Saurya, Saroj, Conduit, Paul T, Baumbach, Janina, Novak, Zsofia A, Aydogan, Mustafa G, Wainman, Alan, Raff, Jordan W

“…Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter…”
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Drosophila Ana1 is required for centrosome assembly and centriole elongation by Saurya, Saroj, Roque, Hélio, Novak, Zsofia A, Wainman, Alan, Aydogan, Mustafa G, Volanakis, Adam, Sieber, Boris, Pinto, David Miguel Susano, Raff, Jordan W

“…Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required…”
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Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo by Baumbach, Janina, Novak, Zsofia Anna, Raff, Jordan W, Wainman, Alan

“…Acentriolar microtubule organizing centers (aMTOCs) are formed during meiosis and mitosis in several cell types, but their function and assembly mechanism is…”
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A molecular mechanism of mitotic centrosome assembly in Drosophila by Conduit, Paul T, Richens, Jennifer H, Wainman, Alan, Holder, James, Vicente, Catarina C, Pratt, Metta B, Dix, Carly I, Novak, Zsofia A, Dobbie, Ian M, Schermelleh, Lothar, Raff, Jordan W

“…Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, but it is unclear…”
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Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP by Conduit, Paul T, Wainman, Alan, Novak, Zsofia A, Weil, Timothy T, Raff, Jordan W

“…Centrosomes have many important functions and comprise a 'mother' and 'daughter' centriole surrounded by pericentriolar material (PCM). The mother centriole…”
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Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster by Sechi, Stefano, Frappaolo, Anna, Fraschini, Roberta, Capalbo, Luisa, Gottardo, Marco, Belloni, Giorgio, Glover, David M., Wainman, Alan, Giansanti, Maria Grazia

“…Cytokinesis requires a tight coordination between actomyosin ring constriction and new membrane addition along the ingressing cleavage furrow. However, the…”
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A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes by Wainman, Alan, Buster, Daniel W, Duncan, Tommy, Metz, Jeremy, Ma, Ao, Sharp, David, Wakefield, James G

“…The Drosophila Augmin complex localizes gamma-tubulin to the microtubules of the mitotic spindle, regulating the density of spindle microtubules in tissue…”
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A microtubule interactome: complexes with roles in cell cycle and mitosis by Hughes, Julian R, Meireles, Ana M, Fisher, Katherine H, Garcia, Angel, Antrobus, Philip R, Wainman, Alan, Zitzmann, Nicole, Deane, Charlotte, Ohkura, Hiroyuki, Wakefield, James G

“…The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell…”
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The Drosophila Pericentrin-like-protein (PLP) cooperates with Cnn to maintain the integrity of the outer PCM by Richens, Jennifer H, Barros, Teresa P, Lucas, Eliana P, Peel, Nina, Pinto, David Miguel Susano, Wainman, Alan, Raff, Jordan W

“…Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in…”
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Expansion microscopy on Drosophila spermatocyte centrioles by Wainman, Alan

“…Drosophila spermatocyte centrioles are ideal for imaging studies. Their large, characteristic V conformation is both easy to identify and measure using…”
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Regulation of centrosome size by the cell-cycle oscillator in Drosophila embryos by Wong, Siu-Shing, Wainman, Alan, Saurya, Saroj, Raff, Jordan W

“…Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar material (PCM) around themselves. In early C. elegans embryos, mitotic…”
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Imaging cellular structures in super-resolution with SIM, STED and Localisation Microscopy: A practical comparison by Wegel, Eva, Göhler, Antonia, Lagerholm, B. Christoffer, Wainman, Alan, Uphoff, Stephan, Kaufmann, Rainer, Dobbie, Ian M.

“…Many biological questions require fluorescence microscopy with a resolution beyond the diffraction limit of light. Super-resolution methods such as Structured…”
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