Search Results - "Wainger, Brian J."

Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs by Hawrot, James, Imhof, Sophie, Wainger, Brian J.

“…Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative disease of the motor nervous system. In order to understand underlying…”
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ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair by Klim, Joseph R., Williams, Luis A., Limone, Francesco, Guerra San Juan, Irune, Davis-Dusenbery, Brandi N., Mordes, Daniel A., Burberry, Aaron, Steinbaugh, Michael J., Gamage, Kanchana K., Kirchner, Rory, Moccia, Rob, Cassel, Seth H., Chen, Kuchuan, Wainger, Brian J., Woolf, Clifford J., Eggan, Kevin

“…The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display pathological mislocalization of the RNA-binding protein TDP-43 and…”
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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons by Wainger, Brian J, Kiskinis, Evangelos, Mellin, Cassidy, Wiskow, Ole, Han, Steve S W, Sandoe, Jackson, Perez, Numa P, Williams, Luis A, Lee, Seungkyu, Boulting, Gabriella, Berry, James D, Brown, Jr, Robert H, Cudkowicz, Merit E, Bean, Bruce P, Eggan, Kevin, Woolf, Clifford J

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp…”
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Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons by Son, Esther Y., Ichida, Justin K., Wainger, Brian J., Toma, Jeremy S., Rafuse, Victor F., Woolf, Clifford J., Eggan, Kevin

“…The mammalian nervous system comprises many distinct neuronal subtypes, each with its own phenotype and differential sensitivity to degenerative disease…”
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Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions by Pereira, João D., DuBreuil, Daniel M., Devlin, Anna-Claire, Held, Aaron, Sapir, Yechiam, Berezovski, Eugene, Hawrot, James, Dorfman, Katherine, Chander, Vignesh, Wainger, Brian J.

“…Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in individual human genetic backgrounds and thus for developing precision…”
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A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS by Yang, Yin M., Gupta, Shailesh K., Kim, Kevin J., Powers, Berit E., Cerqueira, Antonio, Wainger, Brian J., Ngo, Hien D., Rosowski, Kathryn A., Schein, Pamela A., Ackeifi, Courtney A., Arvanites, Anthony C., Davidow, Lance S., Woolf, Clifford J., Rubin, Lee L.

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly…”
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From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial by McNeish, John, Gardner, Jason P., Wainger, Brian J., Woolf, Clifford J., Eggan, Kevin

“…While iPSCs have created unprecedented opportunities for drug discovery, there remains uncertainty concerning the path to the clinic for candidate therapeutics…”
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A functionally characterized test set of human induced pluripotent stem cells by Wichterle, Hynek, Eggan, Kevin, Boulting, Gabriella L, Kiskinis, Evangelos, Croft, Gist F, Amoroso, Mackenzie W, Oakley, Derek H, Wainger, Brian J, Williams, Damian J, Kahler, David J, Yamaki, Mariko, Davidow, Lance, Rodolfa, Christopher T, Dimos, John T, Mikkilineni, Shravani, MacDermott, Amy B, Woolf, Clifford J, Henderson, Christopher E

“…Previous work has suggested that induced pluripotent stem cells (iPSCs) are inferior to embryonic stem cells (ESCs) with respect to in vitro differentiation,…”
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Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy by Bazarek, Stanley, Johnston, Benjamin R., Sten, Margaret, Mandeville, Ross, Eggan, Kevin, Wainger, Brian J., Brown, Justin M.

“…Nerve transfers have become a powerful intervention to restore function following devastating paralyzing injuries. A major limitation to peripheral nerve…”
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Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke by Li, Wenlu, Mandeville, Emiri T., Durán-Laforet, Violeta, Fukuda, Norito, Yu, Zhanyang, Zheng, Yi, Held, Aaron, Park, Ji-Hyun, Nakano, Takafumi, Tanaka, Masayoshi, Shi, Jingfei, Esposito, Elga, Niu, Wanting, Xing, Changhong, Hayakawa, Kazuhide, Lizasoain, Ignacio, van Leyen, Klaus, Ji, Xunming, Wainger, Brian J., Moro, Maria A., Lo, Eng H.

“…The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for…”
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Interleukin-1α links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin by Salib, Anne-Mary N., Crane, Meredith J., Lee, Sang Hun, Wainger, Brian J., Jamieson, Amanda M., Lipscombe, Diane

“…Neurons have the unique capacity to adapt output in response to changes in their environment. Within seconds, sensory nerve endings can become hypersensitive…”
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iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons by Held, Aaron, Adler, Michelle, Marques, Christine, Reyes, Charles Jourdan, Kavuturu, Amey S., Quadros, Ana R.A.A., Ndayambaje, I. Sandra, Lara, Erika, Ward, Michael, Lagier-Tourenne, Clotilde, Wainger, Brian J.

“…Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative…”
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Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons by Moakley, Daniel, Koh, Joan, Pereira, Joao D., DuBreuil, Daniel M., Devlin, Anna-Claire, Berezovski, Eugene, Zhu, Kevin, Wainger, Brian J.

“…Directed differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of specific neuronal subtypes that approximate the intended primary…”
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Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial by Weiss, Michael D., Macklin, Eric A., McIlduff, Courtney E., Vucic, Steve, Wainger, Brian J., Kiernan, Matthew C., Goutman, Stephen A., Goyal, Namita A., Rutkove, Seward B., Ladha, Shafeeq S., Chen, I‐Hweii Amy, Harms, Matthew B., Brannagan, Thomas H., Lacomis, David, Zivkovic, Sasha, Ma, Maxwell, Wang, Leo H., Simmons, Zachary, Rivner, Michael H., Shefner, Jeremy M., Cudkowicz, Merit E., Atassi, Nazem

“…Background To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in…”
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Regulation of HCN Channel Surface Expression by a Novel C-Terminal Protein-Protein Interaction by Santoro, Bina, Wainger, Brian J, Siegelbaum, Steven A

“…Hyperpolarization-activated cation currents (I(h)) are carried by channels encoded by a family of four genes (HCN1-4) that are differentially expressed within…”
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Molecular mechanism of cAMP modulation of HCN pacemaker channels by Tibbs, Gareth R, Wainger, Brian J, DeGennaro, Matthew, Santoro, Bina, Siegelbaum, Steven A

“…Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members…”
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A high-content platform for physiological profiling and unbiased classification of individual neurons by DuBreuil, Daniel M., Chiang, Brenda M., Zhu, Kevin, Lai, Xiaofan, Flynn, Patrick, Sapir, Yechiam, Wainger, Brian J.

“…High-throughput physiological assays lose single-cell resolution, precluding subtype-specific analyses of activation mechanism and drug effects. We demonstrate…”
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Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons by Chahyadinata, Gracesenia, Nam, Joo Hyun, Battenberg, Ashley, Wainger, Brian J

“…Cannabidiol (CBD), the main nonpsychoactive cannabinoid of cannabis, holds promise for nonaddictive treatment of pain. Although preclinical studies have been…”
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A three-dimensional human neural cell culture model of Alzheimer’s disease by Choi, Se Hoon, Kim, Young Hye, Hebisch, Matthias, Sliwinski, Christopher, Lee, Seungkyu, D’Avanzo, Carla, Chen, Hechao, Hooli, Basavaraj, Asselin, Caroline, Muffat, Julien, Klee, Justin B., Zhang, Can, Wainger, Brian J., Peitz, Michael, Kovacs, Dora M., Woolf, Clifford J., Wagner, Steven L., Tanzi, Rudolph E., Kim, Doo Yeon

“…Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures…”
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Taking on the Elephant in the Tissue Culture Room: iPSC Modeling for Sporadic ALS by Wainger, Brian J., Lagier-Tourenne, Clotilde

“…Modeling ALS remains a major challenge since the vast majority of cases are sporadic. Recently in Nature Medicine, Fujimori et al. leverage genetic…”
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