Search Results - "Wainer, I. W."

Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns by Habicht, K-L., Singh, N.S., Khadeer, M.A., Shimmo, R., Wainer, I.W., Moaddel, R.

“…•ABC columns.•Screening against BCRP.•Difference between cellular and nuclear BCRP. Glioblastoma multiforme is an aggressive form of human astrocytoma, with…”
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Automated Ligand Fishing Using Human Serum Albumin-Coated Magnetic Beads by Moaddel, R, Marszałł, M. P, Bighi, F, Yang, Q, Duan, X, Wainer, I. W

“…Human serum albumin, HSA, was immobilized onto the surface of silica-based magnetic beads. The beads were used to isolate known HSA ligands from a mixture…”
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Ligand and Protein Fishing with Heat Shock Protein 90 Coated Magnetic Beads by Marszałł, M. P, Moaddel, R, Kole, S, Gandhari, M, Bernier, M, Wainer, I. W

“…Heat shock protein 90α (Hsp90α) is a molecular chaperone that has been targeted for the development of new anticancer therapies. To date,…”
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Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1) by Moaddel, R, Ravichandran, S, Bighi, F, Yamaguchi, R, Wainer, I W

“…Background and purpose: The human organic cation transporter‐1 (hOCT1) is a polyspecific transporter that plays a role in drug distribution, metabolism and…”
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Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor α and estrogen related receptor γ by Sanghvi, M., Moaddel, R., Frazier, C., Wainer, I.W.

“…The ligand binding domains of the estrogen related receptors, ERRα and ERRγ were covalently immobilized onto the surface of an aminopropyl silica liquid…”
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Characterization of a Multiple Ligand-Gated Ion Channel Cellular Membrane Affinity Chromatography Column and Identification of Endogenously Expressed Receptors in Astrocytoma Cell Lines by Kitabatake, T, Moaddel, R, Cole, R, Gandhari, M, Frazier, C, Hartenstein, J, Rosenberg, A, Bernier, M, Wainer, I. W

“…Cellular membranes obtained from the 1321N1 and A172 astrocytoma cell lines were immobilized on a chromatographic phase to create cellular membrane affinity…”
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Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss by CABAL-MANZANO, R, BHARGAVA, P, TORRES-DUARTE, A, MARSHALL, J, WAINER, I. W

“…Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression…”
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Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters by Can, Adem, Zanos, Panos, Moaddel, Ruin, Kang, Hye Jin, Dossou, Katinia S S, Wainer, Irving W, Cheer, Joseph F, Frost, Douglas O, Huang, Xi-Ping, Gould, Todd D

“…Following administration at subanesthetic doses, (R,S)-ketamine (ketamine) induces rapid and robust relief from symptoms of depression in treatment-refractory…”
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Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase by MOADDEL, R, YAMAGUCHI, R, HO, P. C, PATEL, S, HSU, C.-P, SUBRAHMANYAM, V, WAINER, I. W

“…Membranes from a stably transfected cell line that expresses the human organic cation 1 transporter (hOCT1) have been immobilized on the immobilized artificial…”
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A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks by Villaseñor, A, Ramamoorthy, A, Silva dos Santos, M, Lorenzo, M P, Laje, G, Zarate, C, Barbas, C, Wainer, I W

“…Background and Purpose (R,S)‐ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment‐resistant…”
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Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts by Ciesla, L., Okine, M., Rosenberg, A., Dossou, K.S.S., Toll, L., Wainer, I.W., Moaddel, R.

“…•The α3β4α5 nicotinic receptor was fully characterized.•Anabasine is selective for the α3β4α5 versus the α3β4 nicotinic receptor.•Characterization of…”
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Development and characterization of the alpha 3 beta 4 alpha 5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts by Ciesla, L, Okine, M, Rosenberg, A, Dossou, KSS, Toll, L, Wainer, I W, Moaddel, R

“…The alpha 3 beta 4 alpha 5 nAChR has been recently shown to be a useful target for smoking cessation pharmacotherapies. Herein, we report on the development…”
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Stereoselective binding of 2,3-substituted 3-hydroxypropionic acids on an immobilised human serum albumin chiral stationary phase: stereochemical characterisation and quantitative structure–retention relationship study by Andrisano, V., Bertucci, C., Cavrini, V., Recanatini, M., Cavalli, A., Varoli, L., Felix, G., Wainer, I.W.

“…The binding characteristics of a series of 2,3-substituted 3-hydroxypropionic acids, with anti-inflammatory properties, bearing two chiral centres, were…”
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Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil by Tracy, Timothy S., Korzekwa, Kenneth R., Gonzalez, Frank J., Wainer, Irving W.

“…Aims The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range of cytochrome P450 isoforms…”
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Development of a chromatographic bioreactor based on immobilized β-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine by Calleri, E., Marrubini, G., Massolini, G., Lubda, D., de Fazio, S.S., Furlanetto, S., Wainer, I.W., Manzo, L., Caccialanza, G.

“…We here reported the development and application of an immobilized enzyme reactor (IMER) based on β-glucuronidase to the on-line determination of urinary molar…”
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Achiral and chiral high-performance liquid chromatography of verapamil and its metabolites in serum samples by Brandšteterová, E, Wainer, I.W

“…Rapid and simple achiral and chiral HPLC assays have been developed for the determination of verapamil and its metabolites in serum samples. Two achiral…”
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Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes by GRANVIL, C. P, MADAN, A, SHARKAWI, M, PARKINSON, A, WAINER, I. W

“…The central nervous system toxicity of ifosfamide (IFF), a chiral antineoplastic agent, is thought to be dependent on its N-dechloroethylation by hepatic…”
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Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats by Moaddel, R., Sanghvi, M., Ramamoorthy, A., Jozwiak, K., Singh, N., Green, C., O’Loughlin, K., Torjman, M., Wainer, I.W.

“…•Blood-plasma partitioning of (R,S)-DHNK in rats.•Acute versus subchronic administration of Ket.•Subchronic administration of (R,S)-Ket results in a different…”
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The development of mitochondrial membrane affinity chromatography columns for the study of mitochondrial transmembrane proteins by Habicht, K-L., Singh, N.S., Indig, F.E., Wainer, I.W., Moaddel, R., Shimmo, R.

“…Mitochondrial membrane fragments from U-87 MG (U87MG) and HEK-293 cells were successfully immobilized onto immobilized artificial membrane (IAM)…”
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Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening by Moaddel, R., Rosenberg, A., Spelman, K., Frazier, J., Frazier, C., Nocerino, S., Brizzi, A., Mugnaini, C., Wainer, I.W.

“…Cannabinoid receptors, CB1 and CB2, are therapeutic targets in the treatment of anxiety, obesity, movement disorders, glaucoma, and pain. We have developed an…”
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