Search Results - "Wainer, I"

Reduced Atlantic variability in the mid-Pliocene by Pontes, G. M., Wainer, I., Prado, L., Brierley, C.

“…This study evaluates interannual-to-decadal sea surface temperature (SST) variability in the mid-Pliocene Warm Period within the Pliocene Model Intercomparison…”
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On the Remote Impacts of Mid-Holocene Saharan Vegetation on South American Hydroclimate: A Modeling Intercomparison by Tiwari, S, Ramos, R D, Pausata, F S R, LeGrande, A N, Griffiths, M L, Beltrami, H, Wainer, I, Vernal, A de, Litchmore, D T, Chandan, D, Peltier, W R, Tabor, C R

“…Proxy reconstructions from the mid-Holocene (MH: 6,000 years ago) indicate an intensification of the West African Monsoon and a weakening of the South American…”
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Volcanically Triggered Ocean Warming Near the Antarctic Peninsula by Verona, L. S., Wainer, I., Stevenson, S.

“…Explosive volcanic eruptions are the largest non-anthropogenic perturbations for Earth’s climate, because of the injection of sulfate aerosols into the…”
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A mid-Holocene climate reconstruction for eastern South America by Prado, L. F, Wainer, I, Chiessi, C. M, Ledru, M.-P, Turcq, B

“…The mid-Holocene (6000 calibrated years before present) is a key period in palaeoclimatology because incoming summer insolation was lower than during the late…”
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A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks by Villaseñor, A, Ramamoorthy, A, Silva dos Santos, M, Lorenzo, M P, Laje, G, Zarate, C, Barbas, C, Wainer, I W

“…Background and Purpose (R,S)‐ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment‐resistant…”
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Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts by Ciesla, L., Okine, M., Rosenberg, A., Dossou, K.S.S., Toll, L., Wainer, I.W., Moaddel, R.

“…•The α3β4α5 nicotinic receptor was fully characterized.•Anabasine is selective for the α3β4α5 versus the α3β4 nicotinic receptor.•Characterization of…”
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Development and characterization of the alpha 3 beta 4 alpha 5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts by Ciesla, L, Okine, M, Rosenberg, A, Dossou, KSS, Toll, L, Wainer, I W, Moaddel, R

“…The alpha 3 beta 4 alpha 5 nAChR has been recently shown to be a useful target for smoking cessation pharmacotherapies. Herein, we report on the development…”
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Mid- to late-Holocene paleoceanographic changes on the southeastern Brazilian shelf based on grain size records by Gyllencreutz, R., Mahiques, M.M., Alves, D.V.P., Wainer, I.K.C.

“…High-resolution grain size analyses of three AMS 14C-dated cores from the Southeastern Brazilian shelf provide a detailed record of mid- to late-Holocene…”
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effect of Antarctic sea ice on the Southern Hemisphere atmosphere during the southern summer by Raphael, M. N, Hobbs, W, Wainer, I

“…This study examines the influence of Antarctic sea ice distribution on the large scale circulation of the Southern Hemisphere using a fully coupled GCM where…”
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Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns by Habicht, K-L., Singh, N.S., Khadeer, M.A., Shimmo, R., Wainer, I.W., Moaddel, R.

“…•ABC columns.•Screening against BCRP.•Difference between cellular and nuclear BCRP. Glioblastoma multiforme is an aggressive form of human astrocytoma, with…”
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Automated Ligand Fishing Using Human Serum Albumin-Coated Magnetic Beads by Moaddel, R, Marszałł, M. P, Bighi, F, Yang, Q, Duan, X, Wainer, I. W

“…Human serum albumin, HSA, was immobilized onto the surface of silica-based magnetic beads. The beads were used to isolate known HSA ligands from a mixture…”
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Ligand and Protein Fishing with Heat Shock Protein 90 Coated Magnetic Beads by Marszałł, M. P, Moaddel, R, Kole, S, Gandhari, M, Bernier, M, Wainer, I. W

“…Heat shock protein 90α (Hsp90α) is a molecular chaperone that has been targeted for the development of new anticancer therapies. To date,…”
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Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats by Moaddel, R., Sanghvi, M., Ramamoorthy, A., Jozwiak, K., Singh, N., Green, C., O’Loughlin, K., Torjman, M., Wainer, I.W.

“…•Blood-plasma partitioning of (R,S)-DHNK in rats.•Acute versus subchronic administration of Ket.•Subchronic administration of (R,S)-Ket results in a different…”
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Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1) by Moaddel, R, Ravichandran, S, Bighi, F, Yamaguchi, R, Wainer, I W

“…Background and purpose: The human organic cation transporter‐1 (hOCT1) is a polyspecific transporter that plays a role in drug distribution, metabolism and…”
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The development of mitochondrial membrane affinity chromatography columns for the study of mitochondrial transmembrane proteins by Habicht, K-L., Singh, N.S., Indig, F.E., Wainer, I.W., Moaddel, R., Shimmo, R.

“…Mitochondrial membrane fragments from U-87 MG (U87MG) and HEK-293 cells were successfully immobilized onto immobilized artificial membrane (IAM)…”
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Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening by Moaddel, R., Rosenberg, A., Spelman, K., Frazier, J., Frazier, C., Nocerino, S., Brizzi, A., Mugnaini, C., Wainer, I.W.

“…Cannabinoid receptors, CB1 and CB2, are therapeutic targets in the treatment of anxiety, obesity, movement disorders, glaucoma, and pain. We have developed an…”
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The impacts of deglacial meltwater forcing on the South Atlantic Ocean deep circulation since the Last Glacial Maximum by Marson, J. M, Wainer, I, Mata, M. M, Liu, Z

“…A NCAR-CCSM3 (National Center for Atmospheric Research – Community Climate System Model version 3) state-of-the-art transient paleoclimate simulation with…”
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Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters by Can, Adem, Zanos, Panos, Moaddel, Ruin, Kang, Hye Jin, Dossou, Katinia S S, Wainer, Irving W, Cheer, Joseph F, Frost, Douglas O, Huang, Xi-Ping, Gould, Todd D

“…Following administration at subanesthetic doses, (R,S)-ketamine (ketamine) induces rapid and robust relief from symptoms of depression in treatment-refractory…”
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Onset and End of the Rainy Season in the Brazilian Amazon Basin by Marengo, Jose A., Liebmann, Brant, Kousky, Vernon E., Filizola, Naziano P., Wainer, Ilana C.

“…Onset and end of the rainy season in the Amazon Basin are examined for the period 1979–96. The onset and end dates are determined by averaging daily rainfall…”
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Mineral dust variability in central West Antarctica associated with ozone depletion by Cataldo, M, Evangelista, H, Simões, J. C, Godoi, R. H. M, Simmonds, I, Hollanda, M. H, Wainer, I, Aquino, F, Van Grieken, R

“…We present here data of mineral dust variability retrieved from an ice core of the central West Antarctic, spanning the last five decades. Main evidence…”
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