Search Results - "Wai Liew, Chong"

Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513 by Wong, Yee Hwa, Kumar, Akshita, Liew, Chong Wai, Tharakaraman, Kannan, Srinivasaraghavan, Kannan, Sasisekharan, Ram, Verma, Chandra, Lescar, Julien

“…Dengue is a widespread viral disease with 3.6 billion people at risk worldwide. Humanized monoclonal antibody (mAb) 513, currently undergoing clinical trials…”
Get full text

Expression of the Na⁺/H⁺ antiporter gene (g1-nhaC) of alkaliphilic Bacillus sp. G1 in Escherichia coli by Wai Liew, Chong, Illias, Rosli Md, Muhammad Mahadi, Nor, Najimudin, Nazalan

“…A Na⁺/H⁺ antiporter gene was isolated from alkaliphilic Bacillus sp. G1. The full-length sequence of the Na⁺/H⁺ antiporter gene was obtained using a genome…”
Get full text

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope by Robinson, Luke N., Tharakaraman, Kannan, Rowley, Kirk J., Costa, Vivian V., Chan, Kuan Rong, Wong, Yee Hwa, Ong, Li Ching, Tan, Hwee Cheng, Koch, Tyree, Cain, David, Kirloskar, Rama, Viswanathan, Karthik, Liew, Chong Wai, Tissire, Hamid, Ramakrishnan, Boopathy, Myette, James R., Babcock, Gregory J., Sasisekharan, V., Alonso, Sylvie, Chen, Jianzhu, Lescar, Julien, Shriver, Zachary, Ooi, Eng Eong, Sasisekharan, Ram

“…Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody…”
Get full text

Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor by Noble, Christian G, Lim, Siew Pheng, Chen, Yen-Liang, Liew, Chong Wai, Yap, Lijian, Lescar, Julien, Shi, Pei-Yong

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody by Merigliano, Chiara, Burla, Romina, La Torre, Mattia, Del Giudice, Simona, Teo, Hsiangling, Liew, Chong Wai, Chojnowski, Alexandre, Goh, Wah Ing, Olmos, Yolanda, Maccaroni, Klizia, Giubettini, Maria, Chiolo, Irene, Carlton, Jeremy G, Raimondo, Domenico, Vernì, Fiammetta, Stewart, Colin L, Rhodes, Daniela, Wright, Graham D, Burke, Brian E, Saggio, Isabella

“…To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for…”
Get full text

Structure of a diguanylate cyclase from Thermotoga maritima: insights into activation, feedback inhibition and thermostability by Deepthi, Angeline, Liew, Chong Wai, Liang, Zhao-Xun, Swaminathan, Kunchithapadam, Lescar, Julien

“…Large-scale production of bis-3'-5'-cyclic-di-GMP (c-di-GMP) would facilitate biological studies of numerous bacterial signaling pathways and phenotypes…”
Get full text

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01 by Gu, Yue, Wong, Yee Hwa, Liew, Chong Wai, Chan, Conrad E. Z., Murali, Tanusya M., Yap, Jiawei, Too, Chien Tei, Purushotorman, Kiren, Hamidinia, Maryam, El Sahili, Abbas, Goh, Angeline T. H., Teo, Rachel Z. C., Wood, Kathryn J., Hanson, Brendon J., Gascoigne, Nicholas R. J., Lescar, Julien, Vathsala, Anantharaman, MacAry, Paul A.

“…Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is…”
Get full text

Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis by Liew, Chong Wai, Nilsson, Martina, Chen, Ming Wei, Sun, Huihua, Cornvik, Tobias, Liang, Zhao-Xun, Lescar, Julien

“…Biosynthesis of the enediyne natural product dynemicin in Micromonospora chersina is initiated by DynE8, a highly reducing iterative type I polyketide synthase…”
Get full text

Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation by Gu, Yue, Koh, Robynne W. K., Lai, May Ling, Pochinco, Denise, Teo, Rachel Z. C., Chan, Marieta, Murali, Tanusya M., Liew, Chong Wai, Wong, Yee Hwa, Gascoigne, Nicholas R. J., Wood, Kathryn J., Lescar, Julien, Nickerson, Peter, MacAry, Paul A., Vathsala, Anantharaman

“…The current state-of-the-art technology employed to assess anti-human leukocyte antigen antibodies (Anti-HLA Ab) for donor-recipient matching and patient risk…”
Get full text

A high-throughput cell-based screening method for Zika virus protease inhibitor discovery by Anindita, Paulina Duhita, Otsuka, Yuka, Lattmann, Simon, Ngo, Khac Huy, Liew, Chong Wai, Kang, CongBao, Harris, Reuben S., Scampavia, Louis, Spicer, Timothy P., Luo, Dahai

“…Zika virus (ZIKV) continues to pose a significant global public health threat, with recurring regional outbreaks and potential for pandemic spread. Despite…”
Get full text

Inhibition of falcilysin from Plasmodium falciparum by interference with its closed-to-open dynamic transition by Lin, Jianqing, Yan, Xinfu, Chung, Zara, Liew, Chong Wai, El Sahili, Abbas, Pechnikova, Evgeniya V., Preiser, Peter R., Bozdech, Zbynek, Gao, Yong-Gui, Lescar, Julien

“…In the absence of an efficacious vaccine, chemotherapy remains crucial to prevent and treat malaria. Given its key role in haemoglobin degradation, falcilysin…”
Get full text

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa by Jaroensuk, Juthamas, Wong, Yee Hwa, Zhong, Wenhe, Liew, Chong Wai, Maenpuen, Somchart, Sahili, Abbas E, Atichartpongkul, Sopapan, Chionh, Yok Hian, Nah, Qianhui, Thongdee, Narumon, McBee, Megan E, Prestwich, Erin G, DeMott, Michael S, Chaiyen, Pimchai, Mongkolsuk, Skorn, Dedon, Peter C, Lescar, Julien, Fuangthong, Mayuree

“…The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it…”
Get full text

Solution Structure of the PAS Domain of a Thermophilic YybT Protein Homolog Reveals a Potential Ligand-binding Site by Tan, Edward, Rao, Feng, Pasunooti, Swathi, Pham, Thi Huong, Soehano, Ishin, Turner, Mark S., Liew, Chong Wai, Lescar, Julien, Pervushin, Konstantin, Liang, Zhao-Xun

“…The Bacillus subtilis protein YybT (or GdpP) and its homologs were recently established as stress signaling proteins that exert their biological effect by…”
Get full text

Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis by Kotaka, Masayo, Kong, Rong, Qureshi, Insaf, Ho, Qin Shi, Sun, Huihua, Liew, Chong Wai, Goh, Lan Pei, Cheung, Peter, Mu, Yuguang, Lescar, Julien, Liang, Zhao-Xun

“…The biosynthesis of the enediyne moiety of the antitumor natural product calicheamicin involves an iterative polyketide synthase (CalE8) and other ancillary…”
Get full text

Characterization of a Carbonyl-Conjugated Polyene Precursor in 10-Membered Enediyne Biosynthesis by Kong, Rong, Goh, Lan Pei, Liew, Chong Wai, Ho, Qin Shi, Murugan, Elavazhagan, Li, Bin, Tang, Kai, Liang, Zhao-Xun

“…We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the…”
Get full text

Structure of human Rack1 protein at a resolution of 2.45 Å by Ruiz Carrillo, David, Chandrasekaran, Ramya, Nilsson, Martina, Cornvik, Tobias, Liew, Chong Wai, Tan, Suet Mien, Lescar, Julien

“…The crystal structure of human receptor for activated C‐kinase 1 (hRack1) protein is reported at 2.45 Å resolution. The crystals belongs to space group P41212,…”
Get full text

Structural basis of G-quadruplex DNA recognition by the yeast telomeric protein Rap1 by Traczyk, Anna, Liew, Chong Wai, Gill, David James, Rhodes, Daniela

“…G-quadruplexes are four-stranded nucleic acid structures involved in multiple cellular pathways including DNA replication and telomere maintenance. Such…”
Get full text

Structural Basis for Parallel G‑Quadruplex Recognition by an Ankyrin Protein by Ngo, Khac Huy, Liew, Chong Wai, Heddi, Brahim, Phan, Anh Tuân

“…G-Quadruplex (G4) structures formed by guanine-rich DNA and RNA sequences are implicated in various biological processes. Understanding the mechanisms by which…”
Get full text

Crystal structures of an HIV-1 integrase aptamer: Formation of a water-mediated A•G•G•G•G pentad in an interlocked G-quadruplex by Ngo, Khac Huy, Liew, Chong Wai, Lattmann, Simon, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân

“…93del is a 16-nucleotide G-quadruplex-forming aptamer which can inhibit the activity of the HIV-1 integrase enzyme at nanomolar concentration. Previous…”
Get full text

The human telomeric nucleosome displays distinct structural and dynamic properties by Soman, Aghil, Liew, Chong Wai, Teo, Hsiang Ling, Berezhnoy, Nikolay V, Olieric, Vincent, Korolev, Nikolay, Rhodes, Daniela, Nordenskiöld, Lars

“…Telomeres protect the ends of our chromosomes and are key to maintaining genomic integrity during cell division and differentiation. However, our knowledge of…”
Get full text