Search Results - "Wai, Philip Y."

The role of Osteopontin in tumor metastasis by Wai, Philip Y., Kuo, Paul C.

“…Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous human cancers. OPN functions in cell adhesion, chemotaxis,…”
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Engagement, Workplace Satisfaction, and Retention of Surgical Specialists in Academic Medicine in the United States by Wai, Philip Y., MD, FACS, Dandar, Valerie, MA, Radosevich, David M., RN, PhD, Brubaker, Linda, MD, MS, FACOG, FACS, Kuo, Paul C., MD, MBA, FACS

“…Background Academic medical centers strive for clinical excellence with operational efficiency and financial solvency, which requires institutions to retain…”
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Osteopontin Up-Regulates Critical Epithelial-Mesenchymal Transition Transcription Factors to Induce an Aggressive Breast Cancer Phenotype by Li, Neill Y., BS, Weber, Cynthia E., MD, Mi, Zhiyong, PhD, Wai, Philip Y., MD, Cuevas, Bruce D., PhD, Kuo, Paul C., MD, MBA, FACS

“…Background Tumor cells undergoing epithelial-mesenchymal transition (EMT) develop cellular properties leading to stroma invasion and intravasation. We have…”
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Doing well by doing good: linking access with quality by Chang, Victor, B.A, Kuo, Paul C., M.D., M.B.A., F.A.C.S, Wai, Philip Y., M.D., F.A.C.S

“…Abstract Background We hypothesize that medical centers that prioritize altruism can also deliver superior quality care. Methods Data were obtained from…”
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An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines by Li, Neill Y., BS, Weber, Cynthia E., MD, Wai, Philip Y., MD, Cuevas, Bruce D., PhD, Zhang, Jiwang, PhD, Kuo, Paul C., MD, Mi, Zhiyong, PhD

“…Background Twist is an epithelial-mesenchymal transition (EMT) transcription factor that instigates cell invasion. Our research has shown that osteopontin…”
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Ets-1 and Runx2 Regulate Transcription of a Metastatic Gene, Osteopontin, in Murine Colorectal Cancer Cells by Wai, Philip Y., Mi, Zhiyong, Gao, Chengjiang, Guo, Hongtao, Marroquin, Carlos, Kuo, Paul C.

“…Osteopontin (OPN) is a sialic acid-rich phosphoprotein secreted by a wide variety of cancers. We have shown previously that OPN is necessary for mediating…”
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Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity by Weber, Cynthia E., M.D, Talbot, Lindsay J., M.D, Geller, Justin M., J.D, Kuo, Marissa C, Wai, Philip Y., M.D, Kuo, Paul C., M.D., M.B.A

“…Abstract Background We hypothesized that the increasing body mass index of the population has affected general surgery malpractice claims. Methods We queried…”
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Osteopontin: regulation in tumor metastasis by Wai, Philip Y., Kuo, Paul C.

“…Osteopontin is a secreted phosphoprotein that has been implicated as an important mediator of tumor metastasis and has been investigated for use as a biomarker…”
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Obesity and trends in malpractice claims for physicians and surgeons by Weber, Cynthia E., MD, Talbot, Lindsay J., MD, Geller, Justin M., JD, Kuo, Marissa C, Wai, Philip Y., MD, Kuo, Paul C., MD, MBA

“…Background The increasing prevalence of obesity has altered the practice of medicine and surgery, with the emergence of new operations and medications. We…”
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Impact of business infrastructure on financial metrics in departments of surgery by Wai, Philip Y., MD, O'Hern, Tim, MHA, CMPE, Andersen, Dave O., MHA, FACHE, Kuo, Marissa C, Weber, Cynthia E., MD, Talbot, Lindsay J., MD, Kuo, Paul C., MD, MS, MBA, FACS

“…Background In the current environment, pressure is ever increasing to maximize financial performance in surgery departments. Factors such as physician…”
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Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis by Guo, Hongtao, MD, PhD, Wai, Philip Y., MD, Mi, Zhiyong, PhD, Gao, Chengjiang, PhD, Zhang, Jinping, MD, Kuo, Paul C., MD

“…Background Osteopontin (OPN) represses inducible nitric oxide synthase (iNOS) expression by increasing ubiquitin (Ub)-proteasome degradation of Stat1, a…”
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Transcriptional Regulatory Functions of Heterogeneous Nuclear Ribonucleoprotein-U and -A/B in Endotoxin-Mediated Macrophage Expression of Osteopontin by Gao, Chengjiang, Guo, Hongtao, Mi, Zhiyong, Wai, Philip Y, Kuo, Paul C

“…Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids with diverse regulatory functions, including…”
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Differential Osteopontin Expression in Phenotypically Distinct Subclones of Murine Breast Cancer Cells Mediates Metastatic Behavior by Mi, Zhiyong, Guo, Hongtao, Wai, Philip Y, Gao, Chengjiang, Wei, Junping, Kuo, Paul C

“…Cancer progression depends on an accumulation of metastasis-supporting cell signaling molecules, which target signal transduction pathways and, ultimately,…”
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Epithelial-Mesenchymal Transition, TGF-β, and Osteopontin in Wound Healing and Tissue Remodeling After Injury by WEBER, Cynthia E, LI, Neill Y, WAI, Philip Y, KUO, Paul C

“…Epithelial-mesenchymal transition (EMT) is a process essential to wound healing and tissue remodeling after a thermal burn or other injury. EMT is…”
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Functional analysis of tumor metastasis: modeling colon cancer by Philip Y. Wai, Srinevas K. Reddy, Paul C. Kuo

“…The primary cause of death from colon cancer results from metastases that withstand conventional therapy and escape locoregional control. The molecular…”
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Alcohol Inhibits Osteopontin-dependent Transforming Growth Factor-β1 Expression in Human Mesenchymal Stem Cells by Driver, Joseph, Weber, Cynthia E., Callaci, John J., Kothari, Anai N., Zapf, Matthew A., Roper, Philip M., Borys, Dariusz, Franzen, Carrie A., Gupta, Gopal N., Wai, Philip Y., Zhang, Jiwang, Denning, Mitchell F., Kuo, Paul C., Mi, Zhiyong

“…Alcohol (EtOH) intoxication is a risk factor for increased morbidity and mortality with traumatic injuries, in part through inhibition of bone fracture…”
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Tumor: Stroma Interaction and Cancer by Rogers, Michael P, Mi, Zhiyong, Li, Neill Y, Wai, Philip Y, Kuo, Paul C

“…The understanding of how normal cells transform into tumor cells and progress to invasive cancer and metastases continues to evolve. The tumor mass is…”
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Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells by Mi, Zhiyong, Guo, Hongtao, Wai, Philip Y., Gao, Chengjiang, Kuo, Paul C.

“…Metastasis-supporting physiological alterations are regulated by cell signaling molecules, which target signal transduction pathways and gene expression…”
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Renal Response Following Perioperative Ketorolac Analgesia in Living Kidney Donation by Li, Neill Y, Tong, Liping, Barbas, Andrew S, Bhattacharya, Syamal D, Wai, Philip Y, Kuo, Paul C

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Long-term outcomes after simultaneous pancreas-kidney transplant by Wai, Philip Y, Sollinger, Hans W

“…Simultaneous pancreas-kidney (SPK) transplantation represents the only proven long-term therapeutic approach for type 1 diabetic, dialysis-dependent patients…”
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