Search Results - "Wai, D"
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A brain–spine interface alleviating gait deficits after spinal cord injury in primates
Published in Nature (London) (10-11-2016)“…A wireless brain–spine interface is presented that enables macaques with a spinal cord injury to regain locomotor movements of a paralysed leg. Locomotion…”
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M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia
Published in Neuron (Cambridge, Mass.) (18-11-2015)“…A balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to goal-directed behavior. But how this interaction modulates…”
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Quantum critical phase of FeO spans conditions of Earth’s lower mantle
Published in Nature communications (24-04-2024)“…Seismic and mineralogical studies have suggested regions at Earth’s core-mantle boundary may be highly enriched in FeO, reported to exhibit metallic behavior…”
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Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
Published in Neurology (12-10-2004)“…To examine the clinical, genetic, and neuropathologic features of posterior cortical atrophy (PCA). Using a broad definition of PCA as a syndrome with the…”
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Ab initio approaches to high-entropy alloys: a comparison of CPA, SQS, and supercell methods
Published in Journal of materials science (01-06-2022)“…We present a comparative study of different modeling approaches to the electronic properties of the Hf 0.05 Nb 0.05 Ta 0.8 Ti 0.05 Zr 0.05 high-entropy alloy…”
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Concomitant management of alopecia universalis and ulcerative colitis with upadacitinib
Published in Internal medicine journal (01-09-2024)Get full text
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Why bother using non-human primate models of cognitive disorders in translational research?
Published in Neurobiology of learning and memory (01-10-2015)“…Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models…”
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Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients
Published in Neurology (26-08-2003)“…To determine whether an fMRI memory encoding task distinguishes among cognitively normal elderly individuals, patients with mild cognitive impairment (MCI),…”
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Longitudinal changes in connected speech over a one-year span in the nonfluent/agrammatic variant of Primary Progressive Aphasia
Published in Aphasiology (03-08-2023)“…Connected speech assessment is essential to characterize the language features in primary progressive aphasia (PPA). This is especially true for the…”
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A predicted novel protein isoform of HOXA9
Published in Leukemia research (01-07-2019)Get full text
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Rate of progression differs in frontotemporal dementia and Alzheimer disease
Published in Neurology (09-08-2005)“…To compare survival and rates of cognitive and functional decline in patients with autopsy-confirmed frontotemporal dementia (FTD) and Alzheimer disease (AD)…”
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What to do when traditional rescue therapies fail in acute severe ulcerative colitis
Published in Intestinal research (01-10-2024)“…Acute severe ulcerative colitis (ASUC) is a medical emergency that affects approximately 25% of patients with ulcerative colitis at some point in time in their…”
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M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia
Published in Neuron (Cambridge, Mass.) (01-06-2016)Get full text
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Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1 IGF-1R signalling and reveals TOPK as a new target
Published in British journal of cancer (07-07-2009)“…BACKGROUND : Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription…”
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RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease
Published in Neurobiology of disease (01-10-2014)“…Abstract Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of…”
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Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction
Published in Neurology (28-10-2003)“…Corticobasal degeneration (CBD) typically manifests as progressive asymmetric rigidity and apraxia, although other non-motor presentations have been reported…”
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Experimental animal models of Parkinson's disease: A transition from assessing symptomatology to α-synuclein targeted disease modification
Published in Experimental neurology (01-12-2017)“…With the understanding that α-synuclein plays a major role in the pathogenesis of Parkinson's disease (PD), novel animal models have been developed for…”
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Frontotemporal dementia and parkinsonism associated with the IVS1+1G→A mutation in progranulin: a clinicopathologic study
Published in Brain (London, England : 1878) (01-11-2006)“…We previously reported a kindred with three cases of dementia, in which the proband exhibited features typical of frontotemporal dementia and parkinsonism…”
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Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial
Published in The Lancet (British edition) (12-05-2007)“…Summary Background Guidelines on pain management recommend that patients at risk of ulcers receive either a cyclo-oxygenase (COX 2) inhibitor or a…”
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