Search Results - "Wahl, M."

MDM2, MDMX and p53 in oncogenesis and cancer therapy by Wade, Mark, Li, Yao-Cheng, Wahl, Geoffrey M.

“…Key Points MDM2 and MDMX are RING domain proteins that exert their oncogenic effects primarily by inhibiting the p53 tumour suppressor protein. Each protein is…”
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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas by Toledo, Franck, Wahl, Geoffrey M

“…Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of human cancers, and increased levels of its negative regulators MDM2 and…”
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Enantioselective Desymmetrization of Cyclobutanones: A Speedway to Molecular Complexity by Sietmann, Jan, Wiest, Johannes M.

“…Cyclobutanones hold a privileged role in enantioselective desymmetrization because their inherent ring strain allows for a variety of unusual reactions to…”
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Cysteine depletion induces pancreatic tumor ferroptosis in mice by Badgley, Michael A, Kremer, Daniel M, Maurer, H Carlo, DelGiorno, Kathleen E, Lee, Ho-Joon, Purohit, Vinee, Sagalovskiy, Irina R, Ma, Alice, Kapilian, Jonathan, Firl, Christina E M, Decker, Amanda R, Sastra, Steve A, Palermo, Carmine F, Andrade, Leonardo R, Sajjakulnukit, Peter, Zhang, Li, Tolstyka, Zachary P, Hirschhorn, Tal, Lamb, Candice, Liu, Tong, Gu, Wei, Seeley, E Scott, Stone, Everett, Georgiou, George, Manor, Uri, Iuga, Alina, Wahl, Geoffrey M, Stockwell, Brent R, Lyssiotis, Costas A, Olive, Kenneth P

“…Ferroptosis is a form of cell death that results from the catastrophic accumulation of lipid reactive oxygen species (ROS). Oncogenic signaling elevates lipid…”
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Comparing Jupiter interior structure models to Juno gravity measurements and the role of a dilute core by Wahl, S. M., Hubbard, W. B., Militzer, B., Guillot, T., Miguel, Y., Movshovitz, N., Kaspi, Y., Helled, R., Reese, D., Galanti, E., Levin, S., Connerney, J. E., Bolton, S. J.

“…The Juno spacecraft has measured Jupiter's low‐order, even gravitational moments, J2–J8, to an unprecedented precision, providing important constraints on the…”
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The p53 orchestra: Mdm2 and Mdmx set the tone by Wade, Mark, Wang, Yunyuan V, Wahl, Geoffrey M

“…The activities of p53 cover diverse aspects of cell biology, including cell cycle control, apoptosis, metabolism, fertility, differentiation and cellular…”
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Macroalgae may mitigate ocean acidification effects on mussel calcification by increasing pH and its fluctuations by Wahl, M., Covachã, S. Schneider, Saderne, V., Hiebenthal, C., Müller, J. D., Pansch, C., Sawall, Y.

“…Ocean acidification (OA) is generally assumed to negatively impact calcification rates of marine organisms. At a local scale however, biological activity of…”
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A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer by Spike, Benjamin T., Engle, Dannielle D., Lin, Jennifer C., Cheung, Samantha K., La, Justin, Wahl, Geoffrey M.

“…Gene expression signatures relating mammary stem cell populations to breast cancers have focused on adult tissue. Here, we identify, isolate, and characterize…”
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Evolutionary emergence of infectious diseases in heterogeneous host populations by Chabas, Hélène, Lion, Sébastien, Nicot, Antoine, Meaden, Sean, van Houte, Stineke, Moineau, Sylvain, Wahl, Lindi M, Westra, Edze R, Gandon, Sylvain

“…The emergence and re-emergence of pathogens remains a major public health concern. Unfortunately, when and where pathogens will (re-)emerge is notoriously…”
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Jupiter’s atmospheric jet streams extend thousands of kilometres deep by Kaspi, Y., Galanti, E., Hubbard, W. B., Stevenson, D. J., Bolton, S. J., Iess, L., Guillot, T., Bloxham, J., Connerney, J. E. P., Cao, H., Durante, D., Folkner, W. M., Helled, R., Ingersoll, A. P., Levin, S. M., Lunine, J. I., Miguel, Y., Militzer, B., Parisi, M., Wahl, S. M.

“…The determination of Jupiter’s odd gravitational harmonics by the Juno spacecraft reveals that the observed jet streams extend to about three thousand…”
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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? by Wade, Mark, Wahl, Geoffrey M

“…Genomic and proteomic profiling of human tumor samples and tumor-derived cell lines are essential for the realization of personalized therapy in oncology…”
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A suppression of differential rotation in Jupiter’s deep interior by Guillot, T., Miguel, Y., Militzer, B., Hubbard, W. B., Kaspi, Y., Galanti, E., Cao, H., Helled, R., Wahl, S. M., Iess, L., Folkner, W. M., Stevenson, D. J., Lunine, J. I., Reese, D. R., Biekman, A., Parisi, M., Durante, D., Connerney, J. E. P., Levin, S. M., Bolton, S. J.

“…The determination of Jupiter’s even gravitational moments by the Juno spacecraft reveals that more than three thousand kilometres below the cloud tops,…”
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High-temperature miscibility of iron and rock during terrestrial planet formation by Wahl, Sean M., Militzer, Burkhard

“…The accretion of a terrestrial body and differentiation of its silicate/oxide mantle from iron core provide abundant energy for heating its interior to…”
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Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity by Wahl, Geoffrey M., Spike, Benjamin T.

“…Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the…”
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Calcifying invertebrates succeed in a naturally CO2-rich coastal habitat but are threatened by high levels of future acidification by Thomsen, J, Gutowska, M A, Saphörster, J, Heinemann, A, Trübenbach, K, Fietzke, J, Hiebenthal, C, Eisenhauer, A, Körtzinger, A, Wahl, M, Melzner, F

“…CO2 emissions are leading to an acidification of the oceans. Predicting marine community vulnerability towards acidification is difficult, as adaptation…”
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Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy by Sherman, Mara H., Yu, Ruth T., Engle, Dannielle D., Ding, Ning, Atkins, Annette R., Tiriac, Herve, Collisson, Eric A., Connor, Frances, Van Dyke, Terry, Kozlov, Serguei, Martin, Philip, Tseng, Tiffany W., Dawson, David W., Donahue, Timothy R., Masamune, Atsushi, Shimosegawa, Tooru, Apte, Minoti V., Wilson, Jeremy S., Ng, Beverly, Lau, Sue Lynn, Gunton, Jenny E., Wahl, Geoffrey M., Hunter, Tony, Drebin, Jeffrey A., O’Dwyer, Peter J., Liddle, Christopher, Tuveson, David A., Downes, Michael, Evans, Ronald M.

“…The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to intrinsic chemoresistance and a growth-permissive tumor microenvironment…”
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Single-Cell Chromatin Analysis of Mammary Gland Development Reveals Cell-State Transcriptional Regulators and Lineage Relationships by Chung, Chi-Yeh, Ma, Zhibo, Dravis, Christopher, Preissl, Sebastian, Poirion, Olivier, Luna, Gidsela, Hou, Xiaomeng, Giraddi, Rajshekhar R., Ren, Bing, Wahl, Geoffrey M.

“…Technological improvements enable single-cell epigenetic analyses of organ development. We reasoned that high-resolution single-cell chromatin accessibility…”
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Evolution along the parasitism-mutualism continuum determines the genetic repertoire of prophages by Khan, Amjad, Burmeister, Alita R, Wahl, Lindi M

“…Integrated into their bacterial hosts' genomes, prophage sequences exhibit a wide diversity of length and gene content, from highly degraded cryptic sequences…”
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Allenoates in Enantioselective [2+2] Cycloadditions: From a Mechanistic Curiosity to a Stereospecific Transformation by Wahl, Johannes. M, Conner, Michael L, Brown, M. Kevin

“…Identification of a novel catalyst–allenoate pair allows enantioselective [2+2] cycloaddition of α-methylstyrene. To understand the origin of selectivity, a…”
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Working memory performance of early MS patients correlates inversely with modularity increases in resting state functional connectivity networks by Gamboa, O.L., Tagliazucchi, E., von Wegner, F., Jurcoane, A., Wahl, M., Laufs, H., Ziemann, U.

“…Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating and neurodegenerative disorder of the central nervous system characterized by multifocal…”
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