Search Results - "Wahl, L. M"

Mutual information without the influence of phylogeny or entropy dramatically improves residue contact prediction by Dunn, S.D., Wahl, L.M., Gloor, G.B.

“…Motivation: Compensating alterations during the evolution of protein families give rise to coevolving positions that contain important structural and…”
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Using information theory to search for co-evolving residues in proteins by Martin, L. C., Gloor, G. B., Dunn, S. D., Wahl, L. M.

“…Motivation: Some functionally important protein residues are easily detected since they correspond to conserved columns in a multiple sequence alignment (MSA)…”
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Perspectives on the basic reproductive ratio by Heffernan, J.M, Smith, R.J, Wahl, L.M

“…is defined as the expected number of secondary infections arising from a single individual during his or her entire infectious period, in a population of…”
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Self-tolerance and Autoimmunity in a Regulatory T Cell Model by Alexander, H. K, Wahl, L. M

“…The class of immunosuppressive lymphocytes known as regulatory T cells (Tregs) has been identified as a key component in preventing autoimmune diseases…”
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Age structure is critical to the population dynamics and survival of honeybee colonies by Betti, M. I., Wahl, L. M., Zamir, M.

“…Age structure is an important feature of the division of labour within honeybee colonies, but its effects on colony dynamics have rarely been explored. We…”
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Fixation Probability for Lytic Viruses: The Attachment-Lysis Model by Patwa, Z, Wahl, L. M

“…The fixation probability of a beneficial mutation is extremely sensitive to assumptions regarding the organism's life history. In this article we compute the…”
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The Effects of Population Bottlenecks on Clonal Interference, and the Adaptation Effective Population Size by Campos, Paolo R. A, Wahl, L. M

“…Clonal interference refers to the competition that arises in asexual populations when multiple beneficial mutations segregate simultaneously. A large body of…”
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Fixation Probabilities Depend on Life History: Fecundity, Generation Time and Survival in a Burst-Death Model by Alexander, H. K, Wahl, L. M

“…The burst-death model has been developed to describe the life history of organisms with variable generation times and a burst of a fixed number of offspring…”
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Evolutionary rescue on genotypic fitness landscapes by Wahl, L M, Campos, Paulo R A

“…Populations facing adverse environments, novel pathogens or invasive competitors may be destined to extinction if they are unable to adapt rapidly…”
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The fixation probability of beneficial mutations by Patwa, Z, Wahl, L.M

“…The fixation probability, the probability that the frequency of a particular allele in a population will ultimately reach unity, is one of the cornerstones of…”
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Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects by Smith, R.J., Wahl, L.M.

“…We consider an SIR-type model of immunological behaviour for HIV dynamics, including the effects of reverse transcriptase inhibitors and other drugs which…”
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Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn by STEFANOVA, I, CORCORAN, M. L, HORAK, E. M, WAHL, L. M, BOLEN, J. B, HORAK, I. D

“…Bacterial lipopolysaccharide (LPS) induces a pleiotropic activation of the immune system which might subsequently result in septic shock. One of the cell…”
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Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia by Conant, Katherine, McArthur, Justin C., Griffin, Diane E., Sjulson, Lucas, Wahl, Larry M., Irani, David N.

“…Pathological evidence suggests that alterations of the blood–brain barrier (BBB) may occur in association with human immunodeficiency virus (HIV) dementia…”
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Tumor-Associated Macrophages as Targets for Cancer Therapy by Wahl, Larry M., Kleinman, Hynda K.

“…An editorial argues that tumor-associated macrophages (TAMs) can either directly or indirectly contribute to tumor survival, growth, and metastasis and these…”
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Fixation Probability Favors Increased Fecundity Over Reduced Generation Time by Wahl, L. M, DeHaan, C. S

“…The cornerstone of population genetics is a probabilistic understanding of the ultimate fate--survival or extinction--of rare mutations. If a mutation is…”
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Distinct effects of protease and reverse transcriptase inhibition in an immunological model of HIV-1 infection with impulsive drug effects by Smith, R.J., Wahl, L.M.

“…We present an immunological model that considers the dynamics of CD4 + T cells interacting with free virions, reverse transcriptase inhibiting drugs and…”
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Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus by Karp, Christopher L., Wysocka, Maria, Wahl, Larry M., Ahearn, Joseph M., Cuomo, Peter J., Sherry, Barbara, Trinchieri, Giorgio, Griffin, Diane E.

“…The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived…”
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Monte Carlo simulation of fast excitatory synaptic transmission at a hippocampal synapse by Wahl, L M, Pouzat, C, Stratford, K J

“…1. A simulation of fast excitatory synaptic transmission at a hippocampal synapse is presented. Individual neurotransmitter molecules are followed as they…”
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Fixation when N and s vary: classic approaches give elegant new results by Wahl, L M

“…The expression for the fixation probability ultimately depends on the entire probability distribution for the allele frequency at this time T, which must be…”
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Reproduction Number and Asymptotic Stability for the Dynamics of a Honey Bee Colony with Continuous Age Structure by Betti, M. I., Wahl, L. M., Zamir, M.

“…A system of partial differential equations is derived as a model for the dynamics of a honey bee colony with a continuous age distribution, and the system is…”
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