Search Results - "Wahl, Elizabeth C"

Western Diet Modifies Platelet Activation Profiles in Male Mice by Corken, Adam, Wahl, Elizabeth C, Sikes, James D, Thakali, Keshari M

“…The correlation between obesity and cardiovascular disease has long been understood, yet scant investigations endeavored to determine the impact of an…”
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Cisplatin inhibits bone healing during distraction osteogenesis by Stine, Kimo C., Wahl, Elizabeth C., Liu, Lichu, Skinner, Robert A., VanderSchilden, Jacquelyn, Bunn, Robert C., Montgomery, Corey O., Suva, Larry J., Aronson, James, Becton, David L., Nicholas, Richard W., Swearingen, Christopher J., Lumpkin Jr, Charles K.

“…ABSTRACT Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of…”
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Runt-Related Transcription Factor 2 (RUNX2) and RUNX2-Related Osteogenic Genes Are Down-Regulated throughout Osteogenesis in Type 1 Diabetes Mellitus by Fowlkes, John L, Bunn, R. Clay, Liu, Lichu, Wahl, Elizabeth C, Coleman, Hannah N, Cockrell, Gael E, Perrien, Daniel S, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Type 1 diabetes mellitus is associated with a number of disorders of skeletal health, conditions that rely, in part, on dynamic bone formation. A mouse model…”
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Bone Formation Is Impaired in a Model of Type 1 Diabetes by THRAILKILL, Kathryn M, LICHU LIU, ARONSON, James, LUMPKIN, Charles K, WAHL, Elizabeth C, BUNN, Robert C, PERRIEN, Daniel S, COCKRELL, Gael E, SKINNER, Robert A, HOGUE, William R, CARVER, Adam A, FOWLKES, John L

“…Bone Formation Is Impaired in a Model of Type 1 Diabetes Kathryn M. Thrailkill 1 , Lichu Liu 2 , Elizabeth C. Wahl 2 , Robert C. Bunn 1 , Daniel S. Perrien 3 4…”
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Does Dietary Methionine Alter Perivascular Adipose Tissue Function? by Lee, Davis, Corken, Adam, Wahl, Elizabeth C., Thakali, Keshari M.

“…Perivascular adipose tissue (PVAT) is an adipose depot surrounding blood vessels and is a paracrine regulator of vascular tone. Obesity is associated with the…”
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Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model by Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K

“…DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local…”
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Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice by Fowlkes, John L, Nyman, Jeffry S, Bunn, R Clay, Cockrell, Gael E, Wahl, Elizabeth C, Rettiganti, Mallikarjuna R, Lumpkin, Jr, Charles K, Thrailkill, Kathryn M

“…In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of…”
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SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice by Thrailkill, Kathryn M, Clay Bunn, R, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

“…Abstract Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone,…”
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Increasing duration of type 1 diabetes perturbs the strength–structure relationship and increases brittleness of bone by Nyman, Jeffry S, Even, Jesse L, Jo, Chan-Hee, Herbert, Erik G, Murry, Matthew R, Cockrell, Gael E, Wahl, Elizabeth C, Bunn, R. Clay, Lumpkin, Charles K, Fowlkes, John L, Thrailkill, Kathryn M

“…Abstract Type 1 diabetes (T1DM) increases the likelihood of a fracture. Despite serious complications in the healing of fractures among those with diabetes,…”
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Corrigendum to “SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice” [Bone 82 (2016) 101–107] by Thrailkill, Kathryn M, Bunn, R.C, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

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Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity by Stine, Kimo C., Wahl, Elizabeth C., Liu, Lichu, Skinner, Robert A., VanderSchilden, Jaclyn, Bunn, Robert C., Montgomery, Corey O., Aronson, James, Becton, David L., Nicholas, Richard W., Swearingen, Christopher J., Suva, Larry J., Lumpkin, Charles K.

“…ABSTRACT The majority of Osteosarcoma (OS) patients are treated with a combination of chemotherapy, resection, and limb salvage protocols. These protocols…”
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Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes by Fowlkes, John L, Nyman, Jeffry S, Bunn, R. Clay, Jo, Chanhee, Wahl, Elizabeth C, Liu, Lichu, Cockrell, Gael E, Morris, Lindsey M, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Abstract Objective Using a streptozotocin (STZ)-induced mouse model of type 1 diabetes (T1D), we have previously demonstrated that long-term diabetes inhibits…”
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Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Clark, Lindsey M, Ou, Yang, Isales, Carlos M, Badger, Thomas M, Ronis, Martin J, Sims, John, Lumpkin, Charles K

“…Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised…”
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Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Ronis, Martin J.J, Lumpkin, Charles K

“…Abstract Distraction osteogenesis (DO) is a process which induces direct new bone formation as a result of mechanical distraction. Tumor necrosis factor-α…”
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Distraction osteogenesis in TNF receptor 1 deficient mice is protected from chronic ethanol exposure by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Skinner, Robert A, Ronis, Martin J.J, Lumpkin, Charles K

“…Abstract Distraction osteogenesis (DO) is an orthopedic protocol, which induces direct new bone formation as a result of the stimulating effects of mechanical…”
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A novel rat model for the study of deficits in bone formation in type-2 diabetes by Liu, Zhendong, Aronson, James, Wahl, Elizabeth C, Liu, Lichu, Perrien, Daniel S, Kern, Phillip A, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Cockrell, Gael E, Skinner, Robert A, Lumpkin, Jr, Charles K

“…There is evidence to suggest that impairment in bone formation and/or turnover is associated with the metabolic abnormalities characteristic of type-2 diabetes…”
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Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: Role of the TNF signaling axis by Wahl, Elizabeth C., Aronson, James, Liu, Lichu, Liu, Zhendong, Perrien, Daniel S., Skinner, Robert A., Badger, Thomas M., Ronis, Martin J.J., Lumpkin, Charles K.

“…Tumor necrosis factor-alpha (TNF-α) is an inflammatory cytokine that modulates osteoblastogenesis. In addition, the demonstrated inhibitory effects of chronic…”
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Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes by Bunn, R. Clay, Clark, Lindsey M., Fowlkes, John L., Thrailkill, Kathryn M., Lumpkin, Charles K., Wahl, Elizabeth C., Cockrell, Gael E.

“…Microalbuminuria in humans with Type 1 diabetes (T1D) is associated with increased urinary excretion of megalin, as well as many megalin ligands, including…”
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IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats by Perrien, Daniel S., Wahl, Elizabeth C., Hogue, William R., Feige, Ulrich, Aronson, James, Ronis, Martin J. J., Badger, Thomas M., Lumpkin, Charles K.

“…We tested the hypothesis that combined administration of IL-1 and TNF antagonists would protect fracture healing from inhibition by chronic ethanol exposure…”
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A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation by Wahl, Elizabeth C., Liu, Lichu, Perrien, Daniel S., Aronson, James, Hogue, William R., Skinner, Robert A., Hidestrand, Matts, Ronis, Martin J.J., Badger, Thomas M., Lumpkin, Charles K.

“…Excessive alcohol consumption has been reported to interfere with human bone homeostasis and repair in multiple ways. Previous studies have demonstrated that…”
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