Search Results - "Wahba, Haytham M."

Peroxisome biogenesis initiated by protein phase separation by Ravindran, Rini, Bacellar, Isabel O. L., Castellanos-Girouard, Xavier, Wahba, Haytham M., Zhang, Zhenghao, Omichinski, James G., Kisley, Lydia, Michnick, Stephen W.

“…Peroxisomes are organelles that carry out β-oxidation of fatty acids and amino acids. Both rare and prevalent diseases are caused by their dysfunction 1 …”
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Highly Similar Tetramerization Domains from the p53 Protein of Different Mammalian Species Possess Varying Biophysical, Functional and Structural Properties by Sakaguchi, Shuya, Nakagawa, Natsumi, Wahba, Haytham M, Wada, Junya, Kamada, Rui, Omichinski, James G, Sakaguchi, Kazuyasu

“…The p53 protein is a transcriptional regulatory factor and many of its functions require that it forms a tetrameric structure. Although the tetramerization…”
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Characterization of a C-Terminal SUMO-Interacting Motif Present in Select PIAS-Family Proteins by Lussier-Price, Mathieu, Mascle, Xavier H., Cappadocia, Laurent, Kamada, Rui, Sakaguchi, Kazuyasu, Wahba, Haytham M., Omichinski, James G.

“…The human PIAS proteins are small ubiquitin-like modifier (SUMO) E3 ligases that participate in important cellular functions. Several of these functions depend…”
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An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy by Petraccione, Kaylee, Ali, Mohamed G H, Cyr, Normand, Wahba, Haytham M, Stocker, Timothy, Akhrymuk, Maryna, Akhrymuk, Ivan, Panny, Lauren, Bracci, Nicole, Cafaro, Raphaël, Sastre, Danuta, Silberfarb, Andrew, O'Maille, Paul, Omichinski, James, Kehn-Hall, Kylene

“…Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary…”
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Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR by Ali, Mohamed G., Wahba, Haytham M., Igelmann, Sebastian, Cyr, Normand, Ferbeyre, Gerardo, Omichinski, James G.

“…The Atg8-family proteins (MAP1LC3/LC3A, LC3B, LC3C, GABARAP, GABARAPL1 and GABARAPL2) play a pivotal role in macroautophagy/autophagy through their ability to…”
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Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner by Mascle, Xavier H., Gagnon, Christina, Wahba, Haytham M., Lussier-Price, Mathieu, Cappadocia, Laurent, Sakaguchi, Kazuyasu, Omichinski, James G.

“…The interactions between SUMO proteins and SUMO-interacting motif (SIM) in nuclear bodies formed by the promyelocytic leukemia (PML) protein (PML-NBs) have…”
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Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1 by Lussier-Price, Mathieu, Wahba, Haytham M, Mascle, Xavier H, Cappadocia, Laurent, Bourdeau, Veronique, Gagnon, Christina, Igelmann, Sebastian, Sakaguchi, Kazuyasu, Ferbeyre, Gerardo, Omichinski, James G

“…Abstract SUMO proteins are important regulators of many key cellular functions in part through their ability to form interactions with other proteins…”
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A hydride transfer complex reprograms NAD metabolism and bypasses senescence by Igelmann, Sebastian, Lessard, Frédéric, Uchenunu, Oro, Bouchard, Jacob, Fernandez-Ruiz, Ana, Rowell, Marie-Camille, Lopes-Paciencia, Stéphane, Papadopoli, David, Fouillen, Aurélien, Ponce, Katia Julissa, Huot, Geneviève, Mignacca, Lian, Benfdil, Mehdi, Kalegari, Paloma, Wahba, Haytham M., Pencik, Jan, Vuong, Nhung, Quenneville, Jordan, Guillon, Jordan, Bourdeau, Véronique, Hulea, Laura, Gagnon, Etienne, Kenner, Lukas, Moriggl, Richard, Nanci, Antonio, Pollak, Michael N., Omichinski, James G., Topisirovic, Ivan, Ferbeyre, Gerardo

“…Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly…”
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Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon–Metal Bond Cleavage by Wahba, Haytham M, Stevenson, Michael J, Mansour, Ahmed, Sygusch, Jurgen, Wilcox, Dean E, Omichinski, James G

“…The organomercurial lyase MerB has the unique ability to cleave carbon–Hg bonds, and structural studies indicate that three residues in the active site (C96,…”
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Structural and Biochemical Characterization of a Copper-Binding Mutant of the Organomercurial Lyase MerB: Insight into the Key Role of the Active Site Aspartic Acid in Hg–Carbon Bond Cleavage and Metal Binding Specificity by Wahba, Haytham M, Lecoq, Lauriane, Stevenson, Michael, Mansour, Ahmed, Cappadocia, Laurent, Lafrance-Vanasse, Julien, Wilkinson, Kevin J, Sygusch, Jurgen, Wilcox, Dean E, Omichinski, James G

“…In bacterial resistance to mercury, the organomercurial lyase (MerB) plays a key role in the detoxification pathway through its ability to cleave Hg–carbon…”
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Antimicrobial activity of some Clerodendrum species from Egypt by AbouZid, Sameh F., Wahba, Haytham M., Elshamy, Ali, Cos, Paul, Maes, Louis, Apers, Sandra, Pieters, Luc, Shahat, Abdelaaty A.

“…Chloroformic and methanolic extracts of four Clerodendrum species cultivated in Egypt were screened for antimicrobial activities. Chloroformic extracts of the…”
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Chemical and biological investigation of some Clerodendrum species cultivated in Egypt by Wahba, Haytham M, AbouZid, Sameh F, Sleem, Amany A, Apers, Sandra, Pieters, Luc, Shahat, Abdelaaty A

“…Phytochemical investigation of Clerodendrum chinense (Osbeck) Mabberley (Lamiaceae) cultivated in Egypt and evaluation for anti-inflammatory, analgesic, and…”
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