Search Results - "Wahamaa, H"

Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease by Joshua, Vijay, Loberg Haarhaus, Malena, Hensvold, Aase, Wähämaa, Heidi, Gerstner, Christina, Hansson, Monika, Israelsson, Lena, Stålesen, Ragnhild, Sköld, Magnus, Grunewald, Johan, Klareskog, Lars, Grönwall, Caroline, Réthi, Bence, Catrina, Anca, Malmström, Vivianne

“…The lung is implicated as a site for breach of tolerance prior to onset of seropositive rheumatoid arthritis (RA). To substantiate this, we investigated…”
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IL‐1β/HMGB1 Complexes Promote The PGE2 Biosynthesis Pathway in Synovial Fibroblasts by Leclerc, P., Wähämaa, H., Idborg, H., Jakobsson, P. J., Harris, H. E., Korotkova, M.

“…PGE2 is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase‐1 (mPGES‐1) is a terminal enzyme of the PGE2…”
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Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis by Gunasekera, Sunithi, Fernandes-Cerqueira, Cátia, Wennmalm, Stefan, Wähämaa, Heidi, Sommarin, Yngve, Catrina, Anca I, Jakobsson, Per-Johan, Göransson, Ulf

“…The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived…”
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An Image-based Dynamic High-throughput Analysis of Adherent Cell Migration by Sun, Meng, Rethi, Bence, Krishnamurthy, Akilan, Joshua, Vijay, Wähämaa, Heidi, Catrina, Sergiu-Bogdan, Catrina, Anca

“…In this protocol, we describe a method to monitor cell migration by live-cell imaging of adherent cells. Scratching assay is a common method to investigate…”
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IL‐1β/HMGB1 Complexes Promote The PGE 2 Biosynthesis Pathway in Synovial Fibroblasts by Leclerc, P., Wähämaa, H., Idborg, H., Jakobsson, P. J., Harris, H. E., Korotkova, M.

“…Abstract PGE 2 is a potent lipid mediator of pain and oedema found elevated in RA . Microsomal prostaglandin E synthase‐1 ( mPGES ‐1) is a terminal enzyme of…”
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Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss by Krishnamurthy, Akilan, Joshua, Vijay, Haj Hensvold, Aase, Jin, Tao, Sun, Meng, Vivar, Nancy, Ytterberg, A Jimmy, Engström, Marianne, Fernandes-Cerqueira, Cátia, Amara, Khaled, Magnusson, Malin, Wigerblad, Gustaf, Kato, Jungo, Jiménez-Andrade, Juan Miguel, Tyson, Kerry, Rapecki, Stephen, Lundberg, Karin, Catrina, Sergiu-Bogdan, Jakobsson, Per-Johan, Svensson, Camilla, Malmström, Vivianne, Klareskog, Lars, Wähämaa, Heidi, Catrina, Anca I

“…Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction…”
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JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation by Lu, Ben, Antoine, Daniel J., Kwan, Kevin, Lundbäck, Peter, Wähämaa, Heidi, Schierbeck, Hanna, Robinson, Melissa, Van Zoelen, Marieke A. D., Yang, Huan, Li, Jianhua, Erlandsson-Harris, Helena, Chavan, Sangeeta S., Wang, Haichao, Andersson, Ulf, Tracey, Kevin J.

“…Extracellular high-mobility group box (HMGB)1 mediates inflammation during sterile and infectious injury and contributes importantly to disease pathogenesis…”
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Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts by Krishnamurthy, Akilan, Ytterberg, A Jimmy, Sun, Meng, Sakuraba, Koji, Steen, Johanna, Joshua, Vijay, Tarasova, Nataliya K, Malmström, Vivianne, Wähämaa, Heidi, Réthi, Bence, Catrina, Anca I

“…An increased repertoire of potential osteoclast (OC) precursors could accelerate the development of bone-erosive OCs and the consequent bone damage in…”
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Anca Catrina 1971-2021 Obituary by Klareskog, L, Rethi, B, Hensvold, A, Wahamaa, H, Jakobsson, PJ

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Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts by Sun, Meng, Rethi, Bence, Krishnamurthy, Akilan, Joshua, Vijay, Circiumaru, Alexandra, Hensvold, Aase Haj, Ossipova, Elena, Grönwall, Caroline, Liu, Yanying, Engstrom, Marianne, Catrina, Sergiu Bogdan, Steen, Johanna, Malmstrom, Vivianne, Klareskog, Lars, Svensson, Camilla, Ospelt, Caroline, Wähämaa, Heidi, Catrina, Anca Irinel

“…Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) might contribute to bone loss and arthralgia before the onset of joint…”
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The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation by Hreggvidsdottir, Hulda Sigridur, Ostberg, Therese, Wähämaa, Heidi, Schierbeck, Hanna, Aveberger, Ann-Charlotte, Klevenvall, Lena, Palmblad, Karin, Ottosson, Lars, Andersson, Ulf, Harris, Helena Erlandsson

“…A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. The nuclear protein HMGB1 has previously been demonstrated to…”
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Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis by Hegewald, Anett B, Breitwieser, Kai, Ottinger, Sarah M, Mobarrez, Fariborz, Korotkova, Marina, Rethi, Bence, Jakobsson, Per-Johan, Catrina, Anca I, Wähämaa, Heidi, Saul, Meike J

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular…”
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High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts by Wähämaa, Heidi, Schierbeck, Hanna, Hreggvidsdottir, Hulda S, Palmblad, Karin, Aveberger, Anne-Charlotte, Andersson, Ulf, Harris, Helena Erlandsson

“…In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked…”
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Human Lymph Node Stromal Cells Have the Machinery to Regulate Peripheral Tolerance during Health and Rheumatoid Arthritis by Hähnlein, Janine S, Nadafi, Reza, Jong, Tineke A de, Semmelink, Johanna F, Remmerswaal, Ester B M, Safy, Mary, Lienden, Krijn P van, Maas, Mario, Gerlag, Danielle M, Tak, Paul P, Mebius, Reina E, Wähämaa, Heidi, Catrina, Anca I, G M van Baarsen, Lisa

“…In rheumatoid arthritis (RA) the cause for loss of tolerance and anti-citrullinated protein antibody (ACPA) production remains unidentified. Mouse studies…”
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Arthritis Progression in at Risk Individuals Is Associated with ACPAs Not AMPAs by Circiumaru, A, Kisten, Y, Hansson, M, Wahamaa, H, Sun, M, Joshua, V, Rezaei, H, Af Klint, E, Antovic, A, Catrina, A, Hensvold, AH

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Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation by Cîrciumaru, Alexandra, Afonso, Marcelo Gomes, Wähämaa, Heidi, Krishnamurthy, Akilan, Hansson, Monika, Mathsson-Alm, Linda, Keszei, Márton, Stålesen, Ragnhild, Ottosson, Lars, de Vries, Charlotte, Shelef, Miriam A, Malmström, Vivianne, Klareskog, Lars, Catrina, Anca I, Grönwall, Caroline, Hensvold, Aase, Réthi, Bence

“…Why the adaptive immune system turns against citrullinated antigens in rheumatoid arthritis (RA) and whether anti-citrullinated protein antibodies (ACPAs)…”
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Immunomodulatory drugs regulate HMGB1 release from activated human monocytes by Schierbeck, Hanna, Wähämaa, Heidi, Andersson, Ulf, Harris, Helena Erlandsson

“…Several HMGB1-specific antagonists have provided beneficial results in multiple models of inflammatory disease-preclinical trials including arthritis. Since no…”
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Exploring the RA Bone Marrow Niche by Single-cell Technology to Identify Long Lived ACPA plus Plasma Cells by Amara, K, Hensvold, A, Thyagarajan, R, Israelsson, L, Steen, J, Wahamaa, H, Hansson, M, Engstrom, M, van Vollenhoven, A, Catrina, A, Malmstrom, V, Gronwall, C

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Autoantibodies Against Malondialdehyde--modifications Promote Osteoclast Development by Reprogramming Cellular Metabolism by Sakuraba, K, Krishnamurthy, A, Circiumaru, A, Sun, JT, Joshua, V, Wahamaa, H, Engstrom, M, Sun, M, Zheng, XW, Xu, C, Amara, K, Malmstrom, V, Catrina, S, Gronwall, C, Catrina, A, Rethi, B

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IL-1[beta]/HMGB1 Complexes Promote The PGE2 Biosynthesis Pathway in Synovial Fibroblasts by Leclerc, P, Wahamaa, H, Idborg, H, Jakobsson, P J, Harris, H E, Korotkova, M

“…PGE2 is a potent lipid mediator of pain and oedema found elevated in RA. Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal enzyme of the PGE2…”
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