Search Results - "Wagner, Uwe"

Know thy cells: commonly used triple-negative human breast cancer cell lines carry mutations in RAS and effectors by Wagner, Kay-Uwe

“…Based on the experimental work presented, such a conclusion should be taken with caution due to the simple fact that three of the four claudin-low tumor cell…”
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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets by Witkiewicz, Agnieszka K., McMillan, Elizabeth A., Balaji, Uthra, Baek, GuemHee, Lin, Wan-Chi, Mansour, John, Mollaee, Mehri, Wagner, Kay-Uwe, Koduru, Prasad, Yopp, Adam, Choti, Michael A., Yeo, Charles J., McCue, Peter, White, Michael A., Knudsen, Erik S.

“…Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109…”
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Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents by Asshoff, Malte, Petzer, Verena, Warr, Matthew R., Haschka, David, Tymoszuk, Piotr, Demetz, Egon, Seifert, Markus, Posch, Wilfried, Nairz, Manfred, Maciejewski, Pat, Fowles, Peter, Burns, Christopher J., Smith, Gregg, Wagner, Kay-Uwe, Weiss, Guenter, Whitney, J.Andrew, Theurl, Igor

“…Patients with myelofibrosis (MF) often develop anemia and frequently become dependent on red blood cell transfusions. Results from a phase 2 study for the…”
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Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells by Rädler, Patrick D., Wehde, Barbara L., Wagner, Kay-Uwe

“…Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have been shown to function downstream of several peptide hormones and…”
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Critical Role of Jak2 in the Maintenance and Function of Adult Hematopoietic Stem Cells by Akada, Hajime, Akada, Saeko, Hutchison, Robert E., Sakamoto, Kazuhito, Wagner, Kay‐Uwe, Mohi, Golam

“…Jak2, a member of the Janus kinase family of nonreceptor protein tyrosine kinases, is activated in response to a variety of cytokines, and functions in…”
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Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C by Steitz, Anna Mary, Steffes, Alina, Finkernagel, Florian, Unger, Annika, Sommerfeld, Leah, Jansen, Julia M., Wagner, Uwe, Graumann, Johannes, Müller, Rolf, Reinartz, Silke

“…A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or…”
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Mixed‐polarization phenotype of ascites‐associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse by Reinartz, Silke, Schumann, Tim, Finkernagel, Florian, Wortmann, Annika, Jansen, Julia M., Meissner, Wolfgang, Krause, Michael, Schwörer, Anne‐Marie, Wagner, Uwe, Müller‐Brüsselbach, Sabine, Müller, Rolf

“…Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these…”
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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells by Rädler, Patrick D., Wehde, Barbara L., Triplett, Aleata A., Shrestha, Hridaya, Shepherd, Jonathan H., Pfefferle, Adam D., Rui, Hallgeir, Cardiff, Robert D., Perou, Charles M., Wagner, Kay-Uwe

“…Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem…”
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Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers by Rajbhandari, Nirakar, Lin, Wan-chi, Wehde, Barbara L., Triplett, Aleata A., Wagner, Kay-Uwe

“…Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. Although tumor growth and homeostasis are…”
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Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis by Klein, Sabine, Rick, Johanna, Lehmann, Jennifer, Schierwagen, Robert, Schierwagen, Irela Gretchen, Verbeke, Len, Hittatiya, Kanishka, Uschner, Frank Erhard, Manekeller, Steffen, Strassburg, Christian P, Wagner, Kay-Uwe, Sayeski, Peter P, Wolf, Dominik, Laleman, Wim, Sauerbruch, Tilman, Trebicka, Jonel

“…Angiotensin II (AngII) activates via angiotensin-II-type-I receptor (AT1R) Janus-kinase-2 (JAK2)/Arhgef1 pathway and subsequently RHOA/Rho-kinase (ROCK), which…”
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Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling by Rochman, Yrina, Kashyap, Mohit, Robinson, Gertraud W., Sakamoto, Kazuhito, Gomez-Rodriguez, Julio, Wagner, Kay-Uwe, Leonard, Warren J., Paul, William E.

“…Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays essential roles in allergic/inflammatory skin and airway disorders, in helminth infections,…”
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Estrogen receptor-α expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice by Feng, Yuxin, Manka, David, Wagner, Kay-Uwe, Khan, Sohaib A

“…The estrogen receptor-α (ERα) is a critical transcription factor that regulates epithelial cell proliferation and ductal morphogenesis during postnatal mammary…”
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Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression by Wehde, Barbara L., Rädler, Patrick D., Shrestha, Hridaya, Johnson, Stevi J., Triplett, Aleata A., Wagner, Kay-Uwe

“…Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer…”
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Tumor susceptibility gene 101 is required for the maintenance of uterine epithelial cells during embryo implantation by Byun, Hyunji, Kwon, Sojung, Wagner, Kay-Uwe, Shin, Hyejin, Lim, Hyunjung Jade

“…The tumor susceptibility gene 101 (Tsg101), a component of the endosomal sorting complex required for transport (ESCRT) complex I, is involved in multiple…”
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Pegylated Liposomal Doxorubicin and Carboplatin Compared With Paclitaxel and Carboplatin for Patients With Platinum-Sensitive Ovarian Cancer in Late Relapse by PUJADE-LAURAINE, Eric, WAGNER, Uwe, SEHOULI, Jalid, LORTHOLARY, Alain, KRISTENSEN, Gunnar, JACKISCH, Christian, JOLY, Florence, BROWN, Chris, LE FUR, Nathalie, DU BOIS, Andreas, AAVALL-LUNDQVIST, Elisabeth, GEBSKI, Val, HEYWOOD, Mark, VASEY, Paul A, VOLGGER, Birgit, VERGOTE, Ignace, PIGNATA, Sandro, FERRERO, Annamaria

“…This randomized, multicenter, phase III noninferiority trial was designed to test the efficacy and safety of the combination of pegylated liposomal doxorubicin…”
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Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma by Graumann, Johannes, Finkernagel, Florian, Reinartz, Silke, Stief, Thomas, Brödje, Dörte, Renz, Harald, Jansen, Julia M., Wagner, Uwe, Worzfeld, Thomas, Pogge von Strandmann, Elke, Müller, Rolf

“…A central reason behind the poor clinical outcome of patients with high-grade serous carcinoma (HGSC) of the ovary is the difficulty in reliably detecting…”
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Prognosis of ovarian cancer is associated with effector memory CD8 + T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells by Lieber, Sonja, Reinartz, Silke, Raifer, Hartmann, Finkernagel, Florian, Dreyer, Tobias, Bronger, Holger, Jansen, Julia M, Wagner, Uwe, Worzfeld, Thomas, Müller, Rolf, Huber, Magdalena

“…The accumulation of intratumoral CD8 T cells is associated with the survival of high grade serous ovarian carcinoma patients, but it is unclear which CD8 T…”
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Use Case Evaluation and Digital Workflow of Breast Cancer Care by Artificial Intelligence and Blockchain Technology Application by Griewing, Sebastian, Lingenfelder, Michael, Wagner, Uwe, Gremke, Niklas

“…This study aims at evaluating the use case potential of breast cancer care for artificial intelligence and blockchain technology application based on the…”
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Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis by Schmidt, Jeffrey W., Wehde, Barbara L., Sakamoto, Kazuhito, Triplett, Aleata A., Anderson, Steven M., Tsichlis, Philip N., Leone, Gustavo, Wagner, Kay-Uwe

“…Stat5 (signal transducer and activator of transcription 5) is an essential mediator of cytokine receptor signaling and plays important roles in the…”
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Gemcitabine Plus Carboplatin Compared With Carboplatin in Patients With Platinum-Sensitive Recurrent Ovarian Cancer: An Intergroup Trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG by PFISTERER, Jacobus, PLANTE, Marie, OLBRICHT, Sigrid, LE, Tien, EMERICH, Janusz, KUHN, Walther, BENTLEY, James, JACKISCH, Christian, LÜCK, Hans-Joachim, ROCHON, Justine, ZIMMERMANN, Annamaria Hayden, EISENHAUER, Elizabeth, VERGOTE, Ignace, DU BOIS, Andreas, HIRTE, Hal, LACAVE, Angel J, WAGNER, Uwe, STÄHLE, Anne, STUART, Gavin, KIMMIG, Rainer

“…Most patients with advanced ovarian cancer develop recurrent disease. For those patients who recur at least 6 months after initial therapy, paclitaxel platinum…”
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