Search Results - "Wagner, Ryan T"

Dual gene activation and knockout screen reveals directional dependencies in genetic networks by Boettcher, Michael, Tian, Ruilin, Blau, James A, Markegard, Evan, Wagner, Ryan T, Wu, David, Mo, Xiulei, Biton, Anne, Zaitlen, Noah, Fu, Haian, McCormick, Frank, Kampmann, Martin, McManus, Michael T

“…Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional…”
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SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF‐β‐independent manner by Wang, Tianchu, Wagner, Ryan T., Hlady, Ryan A., Pan, Xiaoyu, Zhao, Xia, Kim, Sungho, Wang, Liguo, Lee, Jeong‐Heon, Luo, Huijun, Castle, Erik P., Lake, Douglas F., Ho, Thai H., Robertson, Keith D.

“…Histone‐lysine N‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is…”
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Minireview: The Diverse Roles of Nuclear Receptors in the Regulation of Embryonic Stem Cell Pluripotency by Wagner, Ryan T, Cooney, Austin J

“…Extensive research has been devoted to the goal of understanding how a single cell of embryonic origin can give rise to every somatic cell type and the germ…”
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Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome by El Khoury, Louis Y, Pan, Xiaoyu, Hlady, Ryan A, Wagner, Ryan T, Shaikh, Shafiq, Wang, Liguo, Humphreys, Mitchell R, Castle, Erik P, Stanton, Melissa L, Ho, Thai H, Robertson, Keith D

“…Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral…”
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Development: Sketch for a Theory of Oct4 by Wagner, Ryan T., Zwaka, Thomas P.

“…How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common…”
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Regulatable in vivo biotinylation expression system in mouse embryonic stem cells by Wang, Qin, Wagner, Ryan T, Cooney, Austin J

“…Embryonic stem (ES) cells have several unique attributes, the two most important of which are they can differentiate into all cell types in the body and they…”
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Stem cell approaches for the treatment of type 1 diabetes mellitus by Wagner, Ryan T, Lewis, Jennifer, Cooney, Austin, Chan, Lawrence

“…Type 1 diabetes is characterized by near total absence of pancreatic b cells. Current treatments consisting of insulin injections and islet transplantation are…”
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Nucleolar-based Dux repression is essential for embryonic two-cell stage exit by Xie, Sheila Q, Leeke, Bryony J, Whilding, Chad, Wagner, Ryan T, Garcia-Llagostera, Ferran, Low, YiXuan, Chammas, Paul, Cheung, Nathan T-F, Dormann, Dirk, McManus, Michael T, Percharde, Michelle

“…Upon fertilization, the mammalian embryo must switch from dependence on maternal transcripts to transcribing its own genome, and in mice this involves the…”
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Canonical Wnt/β‐Catenin Regulation of Liver Receptor Homolog‐1 Mediates Pluripotency Gene Expression by Wagner, Ryan T., Xu, Xueping, Yi, Fei, Merrill, Bradley J., Cooney, Austin J.

“…Delineating the signaling pathways that underlie ESC pluripotency is paramount for development of ESC applications in both the research and clinical settings…”
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Epigenetic heterogeneity hotspots in human liver disease progression by Hlady, Ryan A, Zhao, Xia, El Khoury, Louis Y, Wagner, Ryan T, Luna, Aesis, Pham, Kien, Pyrosopoulos, Nikolaos T, Jain, Dhanpat, Wang, Liguo, Liu, Chen, Robertson, Keith D

“…Disruption of the epigenome is a hallmark of human disease, including liver cirrhosis and HCC. While genetic heterogeneity is an established effector of…”
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Alpha‐1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity by Wang, Liguo, Marek, George W., Hlady, Ryan A., Wagner, Ryan T., Zhao, Xia, Clark, Virginia C., Fan, Alex Xiucheng, Liu, Chen, Brantly, Mark, Robertson, Keith D.

“…Alpha‐1 antitrypsin deficiency (AATD) liver disease is characterized by marked heterogeneity in presentation and progression, despite a common underlying gene…”
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Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts by Conteduca, Giuseppina, Cangelosi, Davide, Baldo, Chiara, Arado, Alessia, Testa, Barbara, Wagner, Ryan T, Robertson, Keith D, Dequiedt, Franck, Fitzsimmons, Lane, Malacarne, Michela, Filaci, Gilberto, Coviello, Domenico A

“…Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic variants promote neoplastic cell transformation. Our previous studies…”
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Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer by El Khoury, Louis Y, Fu, Shuang, Hlady, Ryan A, Wagner, Ryan T, Wang, Liguo, Eckel-Passow, Jeanette E, Castle, Erik P, Stanton, Melissa L, Thompson, R Houston, Parker, Alexander S, Ho, Thai H, Robertson, Keith D

“…Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma…”
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OCT4: Less is more by Wagner, Ryan T, Cooney, Austin J

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The E3 ligase c-Cbl regulates dendritic cell activation by Chiou, Shin-Heng, Shahi, Payam, Wagner, Ryan T, Hu, Hongbo, Lapteva, Natalia, Seethammagari, Mamatha, Sun, Shao-Cong, Levitt, Jonathan M, Spencer, David M

“…The activation of innate and adaptive immunity is always balanced by inhibitory signalling mechanisms to maintain tissue integrity. We have identified the E3…”
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Stem cell approaches for the treatment of type 1 diabetes mellitus : Advances and challenges in translating stem cell therapies for clinical diseases by WAGNER, Ryan T, LEWIS, Jennifer, COONEY, Austin, CHAN, Lawrence

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Regulatable In Vivo Biotinylation Expression System in Mouse Embryonic Stem Cells. e63532 by Wang, Qin, Wagner, Ryan T, Cooney, Austin J

“…Embryonic stem (ES) cells have several unique attributes, the two most important of which are they can differentiate into all cell types in the body and they…”
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