Search Results - "Wagner, Klaus V."

Regulation of the macrophage oxytocin receptor in response to inflammation by Szeto, Angela, Sun-Suslow, Ni, Mendez, Armando J, Hernandez, Rosa I, Wagner, Klaus V, McCabe, Philip M

“…It has been demonstrated that the neuropeptide oxytocin (OT) attenuates oxidative stress and inflammation in macrophages. In the current study, we examined the…”
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Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans by Gassen, Nils C, Hartmann, Jakob, Zschocke, Jürgen, Stepan, Jens, Hafner, Kathrin, Zellner, Andreas, Kirmeier, Thomas, Kollmannsberger, Lorenz, Wagner, Klaus V, Dedic, Nina, Balsevich, Georgia, Deussing, Jan M, Kloiber, Stefan, Lucae, Susanne, Holsboer, Florian, Eder, Matthias, Uhr, Manfred, Ising, Marcus, Schmidt, Mathias V, Rein, Theo

“…FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical…”
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Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss by Wang, Xiao-Dong, Su, Yun-Ai, Wagner, Klaus V, Avrabos, Charilaos, Scharf, Sebastian H, Hartmann, Jakob, Wolf, Miriam, Liebl, Claudia, Kühne, Claudia, Wurst, Wolfgang, Holsboer, Florian, Eder, Matthias, Deussing, Jan M, Müller, Marianne B, Schmidt, Mathias V

“…Early-life stress, acting through corticotrophin-releasing hormone (CRH) and its receptor CRHR1, can have long-lasting effects on animals' behavior. Nectin-3…”
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Evidence supporting the match/mismatch hypothesis of psychiatric disorders by Santarelli, Sara, Lesuis, Sylvie L, Wang, Xiao-Dong, Wagner, Klaus V, Hartmann, Jakob, Labermaier, Christiana, Scharf, Sebastian H, Müller, Marianne B, Holsboer, Florian, Schmidt, Mathias V

“…Abstract Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression…”
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Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling by Wang, Xiao-Dong, Chen, Yuncai, Wolf, Miriam, Wagner, Klaus V, Liebl, Claudia, Scharf, Sebastian H, Harbich, Daniela, Mayer, Bianca, Wurst, Wolfgang, Holsboer, Florian, Deussing, Jan M, Baram, Tallie Z, Müller, Marianne B, Schmidt, Mathias V

“…Abstract Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underlie spatial memory deficits…”
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Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity by Carrillo-Roa, Tania, Labermaier, Christiana, Weber, Peter, Herzog, David P, Lareau, Caleb, Santarelli, Sara, Wagner, Klaus V, Rex-Haffner, Monika, Harbich, Daniela, Scharf, Sebastian H, Nemeroff, Charles B, Dunlop, Boadie W, Craighead, W Edward, Mayberg, Helen S, Schmidt, Mathias V, Uhr, Manfred, Holsboer, Florian, Sillaber, Inge, Binder, Elisabeth B, Müller, Marianne B

“…Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection,…”
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Depletion of FKBP51 in female mice shapes HPA axis activity by Hoeijmakers, Lianne, Harbich, Daniela, Schmid, Bianca, Lucassen, Paul J, Wagner, Klaus V, Schmidt, Mathias V, Hartmann, Jakob

“…Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a major disease burden worldwide and have a higher incidence in women…”
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Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus by Wagner, Klaus V, Hartmann, Jakob, Mangold, Katharina, Wang, Xiao-Dong, Labermaier, Christiana, Liebl, Claudia, Wolf, Miriam, Gassen, Nils C, Holsboer, Florian, Rein, Theo, Müller, Marianne B, Schmidt, Mathias V

“…In recent years, the glutamatergic system has been implicated in the development and treatment of psychiatric disorders. Glutamate signaling is processed by…”
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The stress-inducible actin-interacting protein DRR1 shapes social behavior by Masana, Mercè, Su, Yun-Ai, Liebl, Claudia, Wang, Xiao-Dong, Jansen, Lara, Westerholz, Sören, Wagner, Klaus V, Labermaier, Christiana, Scharf, Sebastian H, Santarelli, Sara, Hartmann, Jakob, Schmidt, Mathias V, Rein, Theo, Müller, Marianne B

“…Summary Understanding the molecular mechanisms by which stress is translated into changes in complex behavior may help to identify novel treatment strategies…”
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Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task by Wagner, Klaus V, Häusl, Alexander S, Pöhlmann, Max L, Hartmann, Jakob, Labermaier, Christiana, Müller, Marianne B, Schmidt, Mathias V

“…Loss of motivation and learning impairments are commonly accepted core symptoms of psychiatric disorders such as depression and schizophrenia. Reward-motivated…”
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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress by Hartmann, Jakob, Wagner, Klaus V., Liebl, Claudia, Scharf, Sebastian H., Wang, Xiao-Dong, Wolf, Miriam, Hausch, Felix, Rein, Theo, Schmidt, Ulrike, Touma, Chadi, Cheung-Flynn, Joyce, Cox, Marc B., Smith, David F., Holsboer, Florian, Müller, Marianne B., Schmidt, Mathias V.

“…Chronic stress is increasingly considered to be a main risk factor for the development of a variety of psychiatric diseases such as depression. This is further…”
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Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51 by Balsevich, Georgia, Uribe, Andres, Wagner, Klaus V, Hartmann, Jakob, Santarelli, Sara, Labermaier, Christiana, Schmidt, Mathias V

“…While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface…”
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Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties by Hartmann, Jakob, Wagner, Klaus V, Gaali, Steffen, Kirschner, Alexander, Kozany, Christian, Rühter, Gerd, Dedic, Nina, Häusl, Alexander S, Hoeijmakers, Lianne, Westerholz, Sören, Namendorf, Christian, Gerlach, Tamara, Uhr, Manfred, Chen, Alon, Deussing, Jan M, Holsboer, Florian, Hausch, Felix, Schmidt, Mathias V

“…Anxiety-related psychiatric disorders represent one of the largest health burdens worldwide. Single nucleotide polymorphisms of the FK506 binding protein 51…”
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Homer1/mGluR5 activity moderates vulnerability to chronic social stress by Wagner, Klaus V, Hartmann, Jakob, Labermaier, Christiana, Häusl, Alexander S, Zhao, Gengjing, Harbich, Daniela, Schmid, Bianca, Wang, Xiao-Dong, Santarelli, Sara, Kohl, Christine, Gassen, Nils C, Matosin, Natalie, Schieven, Marcel, Webhofer, Christian, Turck, Christoph W, Lindemann, Lothar, Jaschke, Georg, Wettstein, Joseph G, Rein, Theo, Müller, Marianne B, Schmidt, Mathias V

“…Stress-induced psychiatric disorders, such as depression, have recently been linked to changes in glutamate transmission in the central nervous system…”
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Differences in FKBP51 Regulation Following Chronic Social Defeat Stress Correlate with Individual Stress Sensitivity: Influence of Paroxetine Treatment by WANER, Klaus V, MARINESCU, Daria, SCHMIDT, Mathias V, HARTMANN, Jakob, WANG, Xiao-Dong, LABERMAIER, Christiana, SCHARF, Sebastian H, LIEBL, Claudia, UHR, Manfred, HOLSBOER, Florian, MÜLLER, Marianne B

“…Various clinical studies have identified FK506-binding protein 51 (FKBP51) as a target gene involved in the development of psychiatric disorders such as…”
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Molecular evidence of synaptic pathology in the CA1 region in schizophrenia by Matosin, Natalie, Fernandez-Enright, Francesca, Lum, Jeremy S, Engel, Martin, Andrews, Jessica L, Gassen, Nils C, Wagner, Klaus V, Schmidt, Mathias V, Newell, Kelly A

“…Alterations of postsynaptic density (PSD)95-complex proteins in schizophrenia ostensibly induce deficits in synaptic plasticity, the molecular process…”
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Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress by Wagner, Klaus V, Wang, Xiao-Dong, Liebl, Claudia, Scharf, Sebastian H, Müller, Marianne B, Schmidt, Mathias V

“…Summary The incidence of chronic stress is frequently related to the development of psychiatric disorders like depression. The hypothalamic-pituitary–adrenal…”
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Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice by Hartmann, Jakob, Wagner, Klaus V, Dedic, Nina, Marinescu, Daria, Scharf, Sebastian H, Wang, Xiao-Dong, Deussing, Jan M, Hausch, Felix, Rein, Theo, Schmidt, Ulrike, Holsboer, Florian, Müller, Marianne B, Schmidt, Mathias V

“…Summary Aversive life events represent one of the main risk factors for the development of many psychiatric diseases, but the interplay between environmental…”
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A Polymorphism in the Crhr1 Gene Determines Stress Vulnerability in Male Mice by Labermaier, Christiana, Kohl, Christine, Hartmann, Jakob, Devigny, Christian, Altmann, Andre, Weber, Peter, Arloth, Janine, Quast, Carina, Wagner, Klaus V, Scharf, Sebastian H, Czibere, Ludwig, Widner-Andrä, Regina, Brenndörfer, Julia, Landgraf, Rainer, Hausch, Felix, Jones, Ken A, Müller, Marianne B, Uhr, Manfred, Holsboer, Florian, Binder, Elisabeth B, Schmidt, Mathias V

“…Chronic stress is a risk factor for psychiatric disorders but does not necessarily lead to uniform long-term effects on mental health, suggesting modulating…”
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Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders by Arloth, Janine, Bogdan, Ryan, Weber, Peter, Frishman, Goar, Menke, Andreas, Wagner, Klaus V., Schmidt, Mathias V., Karbalai, Nazanin, Czamara, Darina, Altmann, Andre, Trümbach, Dietrich, Wurst, Wolfgang, Mehta, Divya, Carey, Caitlin E., Conley, Emily Drabant, Ripke, Stephan, Wray, Naomi R., Lewis, Cathryn M., Hamilton, Steven P., Blackwood, Douglas H.R., Boomsma, Dorret I., Cichon, Sven, Heath, Andrew C., Holsboer, Florian, Muglia, Pierandrea, Noethen, Markus M., Penninx, Brenda P., Pergadia, Michele L., Potash, James B., Lin, Danyu, Müller-Myhsok, Bertram, Shi, Jianxin, Steinberg, Stacy, Grabe, Hans J., Lichtenstein, Paul, Perlis, Roy H., Preisig, Martin, Smoller, Jordan W., Kutalik, Zoltan, Tansey, Katherine E., Teumer, Alexander, Bettecken, Thomas, Binder, Elisabeth B., Breuer, René, Castro, Victor M., Coryell, William H., Craddock, Nick, Czamara, Darina, Degenhardt, Franziska, Fava, Maurizio, Frank, Josef, Gainer, Vivian S., Gallagher, Patience J., Gordon, Scott D., Goryachev, Sergey, Guipponi, Michel, Henders, Anjali K., Hickie, Ian B., Hottenga, Jouke Jan, Jones, Ian, Jones, Lisa, Jung-Ying, Tzeng, Knowles, James A., Kohane, Isaac S., Kohli, Martin A., Korszun, Ania, Landen, Mikael, Lawson, William B., Lewis, Glyn, MacIntyre, Donald, Maier, Wolfgang, Mattheisen, Manuel, McGrath, Patrick J., McIntosh, Andrew, McLean, Alan, Montgomery, Grant M., Murphy, Shawn N., Nauck, Matthias, O’Donovan, Michael, Oskarsson, Högni, Pedersen, Nancy, Schulz, Andrea, Schulze, Thomas G., Shyn, Stanley I., Sigurdsson, Engilbert, Slager, Susan L., Smit, Johannes H., Stefansson, Hreinn, Steffens, Michael, Tozzi, Federica, Treutlein, Jens, Völzke, Henry, Weilburg, Jeffrey B., Willemsen, Gonneke, Neale, Benjamin, Daly, Mark, Levinson, Douglas F., Müller-Myhsok, Bertram, Hariri, Ahmad R., Binder, Elisabeth B.

“…Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer…”
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