Search Results - "Wagner, Jürgen"

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes by Wagner, Jürgen, von Matt, Peter, Sedrani, Richard, Albert, Rainer, Cooke, Nigel, Ehrhardt, Claus, Geiser, Martin, Rummel, Gabriele, Stark, Wilhelm, Strauss, Andre, Cowan-Jacob, Sandra W, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was found to be a potent,…”
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High task interdependence: job rotation and other approaches for overcoming ingroup favoritism by Wagner, Jürgen P, Grigg, Nigel, Mann, Robin, Mohammad, Musli

“…Purpose The purpose of this paper is to investigate how the basic problem of ingroup favoritism in a setting of high task interdependence is addressed through…”
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Business Excellence Model: An overarching framework for managing and aligning multiple organisational improvement initiatives by Mohammad, Musli, Mann, Robin, Grigg, Nigel, Wagner, Jürgen P.

“…Business Excellence Models (BEMs) are used by organisations to assess and improve their work practices and performance. The authors' research identified that…”
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Testing a theoretical model underlying the 'Toyota Way' - an empirical study involving a large global sample of Toyota facilities by Jayamaha, Nihal P., Wagner, Jürgen P., Grigg, Nigel P., Campbell-Allen, Nicky M., Harvie, Warwick

“…In this paper, we empirically test the theoretical model underlying the Toyota Way (TW), based on data obtained from Toyota's logistics, sales and marketing…”
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Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains by Feil, Robert, Wagner, Jürgen, Metzger, Daniel, Chambon, Pierre

“…Ligand-dependent chimeric Cre recombinases are powerful tools to induce specific DNA rearrangements in cultured cells and in mice. We report here the…”
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The Paradigm Shift in Understanding the Bias Temperature Instability: From Reaction-Diffusion to Switching Oxide Traps by Grasser, T., Kaczer, B., Goes, W., Reisinger, H., Aichinger, T., Hehenberger, P., Wagner, P., Schanovsky, F., Franco, J., Luque, María Toledano, Nelhiebel, M.

“…One of the most important degradation modes in CMOS technologies, the bias temperature instability (BTI) has been known since the 1960s. Already in early…”
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Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis by Wagner, Jürgen, von Matt, Peter, Faller, Bernard, Cooke, Nigel G, Albert, Rainer, Sedrani, Richard, Wiegand, Hansjörg, Jean, Christian, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard, Cottens, Sylvain

“…Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the structure–activity…”
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Interaction between intradialytic exercise and hemodialysis adequacy by Kirkman, Danielle L, Roberts, Lisa D, Kelm, Marten, Wagner, Jürgen, Jibani, Mahdi M, Macdonald, Jamie H

“…According to mathematical modeling, intradialytic exercise of sufficient intensity and duration implemented in the second half of dialysis should be as…”
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Ordered Arrays of Large Latex Particles Organized by Vertical Deposition by Goldenberg, Leonid M, Wagner, Jürgen, Stumpe, Joachim, Paulke, Bernd-R, Görnitz, Eckhard

“…A simple preparation method of ordered multilayer films of submicrometer- and micrometer-sized monodisperse latex particles in the broad range of 0.2−2.5 μm is…”
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Darbepoetin alfa effectively maintains haemoglobin concentrations at extended dose intervals relative to intravenous or subcutaneous recombinant human erythropoietin in dialysis patients by Brunkhorst, Reinhard, Bommer, Jürgen, Braun, Johann, Haag-Weber, Marianne, Gill, Caroline, Wagner, Jürgen, Wagener, Thomas

“…Background. Darbepoetin alfa is a unique molecule that stimulates erythropoiesis by the same mechanism as endogenous erythropoietin. Due to its ∼3-fold longer…”
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13- cis Retinoic Acid Inhibits Development and Progression of Chronic Allograft Nephropathy by Adams, Judith, Kiss, Eva, Arroyo, Ana B.V., Bonrouhi, Mahnaz, Sun, Qiang, Li, Zhen, Gretz, Norbert, Schnitger, Anna, Zouboulis, Christos C., Wiesel, Manfred, Wagner, Jürgen, Nelson, Peter J., Gröne, Hermann-Josef

“…Chronic allograft nephropathy is characterized by chronic inflammation and fibrosis. Because retinoids exhibit anti-proliferative, anti-inflammatory, and…”
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Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria by Taft, Benjamin R, Yokokawa, Fumiaki, Kirrane, Tom, Mata, Anne-Catherine, Huang, Richard, Blaquiere, Nicole, Waldron, Grace, Zou, Bin, Simon, Oliver, Vankadara, Subramanyam, Chan, Wai Ling, Ding, Mei, Sim, Sandra, Straimer, Judith, Guiguemde, Armand, Lakshminarayana, Suresh B, Jain, Jay Prakash, Bodenreider, Christophe, Thompson, Christopher, Lanshoeft, Christian, Shu, Wei, Fang, Eric, Qumber, Jafri, Chan, Katherine, Pei, Luying, Chen, Yen-Liang, Schulz, Hanna, Lim, Jessie, Abas, Siti Nurdiana, Ang, Xiaoman, Liu, Yugang, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Gamo, Francisco Javier, Crespo-Fernandez, Benigno, Rosenthal, Philip J, Cooper, Roland A, Tumwebaze, Patrick, Aguiar, Anna Caroline Campos, Campo, Brice, Campbell, Simon, Wagner, Jürgen, Diagana, Thierry T, Sarko, Christopher

“…A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium…”
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Time-dependent defect spectroscopy for characterization of border traps in metal-oxide-semiconductor transistors by Grasser, Tibor, Reisinger, Hans, Wagner, Paul-Jürgen, Kaczer, Ben

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Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus by WAGNER, J, GEHLEN, F, CIECHANOWICZ, A, RITZ, E

“…The renin-angiotensin system plays an important role in the progression of chronic renal disease. Although the expression of renin and angiotensin-converting…”
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Endothelin a receptor blockade prevents capillary/myocyte mismatch in the heart of uremic animals by AMANN, Kerstin, MÜNTER, Klaus, WESSELS, Sabine, WAGNER, Jürgen, BALAJEW, Vitali, HERGENRÖDER, Stefan, MALL, Gerhard, RITZ, Eberhard

“…In the heart of uremic animals and patients, the number of capillaries per volume of myocardium is reduced. Immunohistochemical studies demonstrated increased…”
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Simple Method for the Preparation of Colloidal Particle Monolayers at the Water/Alkane Interface by Goldenberg, Leonid M, Wagner, Jürgen, Stumpe, Joachim, Paulke, Bernd-R, Görnitz, Eckhard

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Effects of all-trans retinoic acid on renin-angiotensin system in rats with experimental nephritis by Dechow, C, Morath, C, Peters, J, Lehrke, I, Waldherr, R, Haxsen, V, Ritz, E, Wagner, J

“…We previously demonstrated that all-trans retinoic acid (RA) preserves glomerular structure and function in anti-Thy1.1 nephritis (Wagner J, Dechow C, Morath…”
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What are the driving forces for water lifting in the xylem conduit? by Zimmermann, Ulrich, Schneider, Heike, Wegner, Lars H., Wagner, Hans‐Jürgen, Szimtenings, Michael, Haase, Axel, Bentrup, Friedrich‐Wilhelm

“…After Renner had shown convincingly in 1925 that the transpirational water loss generates tensions larger than 0.1 MPa (i.e. negative pressures) in the xylem…”
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Effectiveness and Efficiency of Disclosure: A Preparer’s Perspective by Wagner, Jürgen M.

“…Transparent corporate reports are required for reducing the asymmetric distribution of information between providers of capital and company management. In…”
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Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo by MADRY, Henning, RESZKA, Regina, BOHLENDER, Jürgen, WAGNER, Jürgen

“…Mesangial cells represent a major target for gene transfer approaches to the kidney. To establish a liposome-based system for transfection of mesangial cells…”
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