Search Results - "Wagner, Connie J"

Glucocorticoids Improve Calcium Cycling in Cardiac Myocytes After Cardiopulmonary Bypass by Pearl, Jeffrey M., M.D, Plank, David M., M.D., Ph.D, McLean, Kelly M., M.D, Wagner, Connie J., B.S, Duffy, Jodie Y., Ph.D

“…Background Glucocorticoids can reduce myocardial dysfunction associated with ischemia and reperfusion injury following cardiopulmonary bypass (CPB) and…”
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Glucocorticoids Alter the Balance Between Pro- and Anti-inflammatory Mediators in the Myocardium in a Porcine Model of Brain Death by McLean, Kelly M., MD, Duffy, Jodie Y., PhD, Pandalai, Prakash K., MD, Lyons, Jefferson M., MD, Bulcao, Christian F., MD, MBA, Wagner, Connie J., BS, Akhter, Shahab A., MD, Pearl, Jeffrey M., MD

“…Background Cardiac dysfunction after brain death (BD) limits donors for cardiac transplantation. Glucocorticoids ameliorate brain death–induced donor heart…”
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Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts by Pearl, Jeffrey M, Nelson, David P, Schwartz, Steven M, Wagner, Connie J, Bauer, Steven M, Setser, Elizabeth A, Duffy, Jodie Y

“…Background. Transient myocardial dysfunction often occurs after ischemia-reperfusion with immature myocardium appearing particularly susceptible. Neutrophil…”
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Beta-adrenergic Receptor Antagonism Preserves Myocardial Function After Brain Death in a Porcine Model by McLean, Kelly M., MD, Pandalai, Prakash K., MD, Pearl, Jeffrey M., MD, Bulcao, Christian F., MD, MBA, Lyons, Jefferson M., MD, Wagner, Connie J., BS, Akhter, Shahab A., MD, Duffy, Jodie Y., PhD

“…Background Cardiac dysfunction after brain death decreases the already limited number of potential donors for cardiac transplantation. Acute beta-adrenergic…”
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Preoperative glucocorticoids decrease pulmonary hypertension in piglets after cardiopulmonary bypass and circulatory arrest by Pearl, Jeffrey M, Schwartz, Steven M, Nelson, David P, Wagner, Connie J, Lyons, Jefferson M, Bauer, Steven M, Duffy, Jodie Y

“…Glucocorticoids during cardiopulmonary bypass benefit pediatric patients undergoing repair of congenital heart defects and are routine therapy, but underlying…”
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Modulation of nuclear factor-kappaB improves cardiac dysfunction associated with cardiopulmonary bypass and deep hypothermic circulatory arrest by Duffy, Jodie Y, McLean, Kelly M, Lyons, Jefferson M, Czaikowski, Adam J, Wagner, Connie J, Pearl, Jeffrey M

“…OBJECTIVE:The hypothesis is that partial nuclear factor-kappaB (NF-κB) inhibition can alleviate cardiopulmonary dysfunction associated with ischemia and…”
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Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion by Kaiser, Robert A, Lyons, Jefferson M, Duffy, Jodie Y, Wagner, Connie J, McLean, Kelly M, O'Neill, Timothy P, Pearl, Jeffrey M, Molkentin, Jeffery D

“…The MAPK family member p38 is activated in the heart after ischemia-reperfusion (I/R) injury. However, the cardioprotective vs. proapoptotic effects associated…”
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Glucocorticoid administration reduces cardiac dysfunction after brain death in pigs by Lyons, Jefferson M, Pearl, Jeffrey M, McLean, Kelly M, Akhter, Shahab A, Wagner, Connie J, Pandalai, Prakash K, Duffy, Jodie Y

“…Traumatic brain injury and subsequent brain death (BD) account for nearly half of all organ donors, yet only 33% of available hearts are transplanted…”
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Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest by Duffy, Jodie Y, Schwartz, Steven M, Lyons, Jefferson M, Bell, Jason H, Wagner, Connie J, Zingarelli, Basilia, Pearl, Jeffrey M

“…OBJECTIVE:Cardiopulmonary bypass in infants and children can result in cardiopulmonary dysfunction through ischemia and reperfusion injury. Pulmonary…”
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Glucocorticoids preserve calpastatin and troponin I during cardiopulmonary bypass in immature pigs by SCHWARTZ, Steven M, DUFFY, Jodie Y, PEARL, Jeffrey M, GOINS, Semin, WAGNER, Connie J, NELSON, David P

“…Degradation of troponin I (TnI) by calpain occurs with myocardial stunning in ischemia-reperfusion injury. Glucocorticoids attenuate myocardial…”
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Role of the β-adrenergic receptor kinase in myocardial dysfunction after brain death by Pandalai, Prakash K., Lyons, Jefferson M., Duffy, Jodie Y., McLean, Kelly M., Wagner, Connie J., Merrill, Walter H., Pearl, Jeffrey M., Akhter, Shahab A.

“…Significant cardiac dysfunction after brain death leading to exclusion from procurement for cardiac transplantation is seen in up to 25% of potential organ…”
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Sildenafil citrate alleviates pulmonary hypertension after hypoxia and reoxygenation with cardiopulmonary bypass by Lyons, Jefferson M., Duffy, Jodie Y., Wagner, Connie J., Pearl, Jeffrey M.

“…Sudden reoxygenation of hypoxic neonates undergoing cardiac operation exacerbates the systemic inflammatory response to cardiopulmonary bypass secondary to…”
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Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets by Duffy, Jodie Y, Nelson, David P, Schwartz, Steven M, Wagner, Connie J, Bauer, Steven M, Lyons, Jefferson M, McNamara, Jerri L, Pearl, Jeffrey M

“…The hypotheses were that glucocorticoid administration could improve ventricular recovery by reducing cardiopulmonary bypass (CPB)-induced inflammatory…”
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Superoxide dismutase reduces reoxygenation-induced cardiopulmonary dysfunction in the immature heart by Pearl, Jeffery M., Wagner, Connie J., McNamara, Jerri L., Duffy, Jodie Y.

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Endothelin receptor blockade reduces ventricular dysfunction and injury after reoxygenation by Pearl, Jeffrey M, Nelson, David P, Wagner, Connie J, Lombardi, John P, Duffy, Jodie Y

“…Background. Reoxygenation of hypoxic myocardium during repair of congenital heart defects results in poor ventricular function and cellular injury…”
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Bosentan prevents hypoxia-reoxygenation–induced pulmonary hypertension and improves pulmonary function by Pearl, Jeffrey M, Wellmann, Scott A, McNamara, Jerri L, Lombardi, John P, Wagner, Connie J, Raake, Jenni L, Nelson, David P

“…Background. Acute hypoxia results in increased pulmonary vascular resistance. Despite reoxygenation, pulmonary vascular resistance remains elevated and…”
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Acute hypoxia and reoxygenation impairs exhaled nitric oxide release and pulmonary mechanics by Pearl, Jeffrey M., Nelson, David P., Wellmann, Scott A., Raake, Jenni L., Wagner, Connie J., McNamara, Jerri L., Duffy, Jodie Y.

“…Objective: Changes in exhaled nitric oxide levels often accompany conditions associated with elevated pulmonary vascular resistance and altered lung mechanics…”
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Glucocorticoids suppress pulmonary hypertension after cardiopulmonary bypass by reducing endothelin and neutrophil adhesion molecules in neonatal lungs by Pearl, Jeffrey M., Schwartz, Steven M., Nelson, David P., Wagner, Connie J., Lombardi, John P., Duffy, Jodie Y.

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Role of the {beta}-adrenergic receptor kinase in myocardial dysfunction after brain death by Pandalai, Prakash K, Lyons, Jefferson M, Duffy, Jodie Y, McLean, Kelly M, Wagner, Connie J, Merrill, Walter H, Pearl, Jeffrey M, Akhter, Shahab A

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Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts. Discussion by PEARL, Jeffrey M, NELSON, David P, CALDARONE, Christopher A, SCHWARTZ, Steven M, WAGNER, Connie J, BAUER, Steven M, SETSER, Elizabeth A, DUFFY, Jodie Y, NEMOTO, Shintaro, DRINKWATER, David C, MORITZ, Anton

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