Search Results - "Wagner, Carsten A."

Renal phosphate handling and inherited disorders of phosphate reabsorption: an update by Wagner, Carsten A., Rubio-Aliaga, Isabel, Hernando, Nati

“…Renal phosphate handling critically determines plasma phosphate and whole body phosphate levels. Filtered phosphate is mostly reabsorbed by Na + -dependent…”
Get full text

Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations by Lederer, Eleanor, Wagner, Carsten A.

“…The Na + -dependent phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with…”
Get full text

Paracellular transport of phosphate along the intestine by Knöpfel, Thomas, Himmerkus, Nina, Günzel, Dorothee, Bleich, Markus, Hernando, Nati, Wagner, Carsten A

“…Inorganic phosphate (P ) is crucial for many biological functions, such as energy metabolism, signal transduction, and pH buffering. Efficient systems must…”
Get more information

Molecular Mechanisms of Acid-Base Sensing by the Kidney by BROWN, Dennis, WAGNER, Carsten A

“…A major function of the kidney is to collaborate with the respiratory system to maintain systemic acid-base status within limits compatible with normal cell…”
Get full text

Regulation of renal pendrin activity by aldosterone by Bourgeois, Soline, Wagner, Carsten A.

“…PURPOSE OF REVIEWPendrin resides on the luminal membrane of type B intercalated cells in the renal collecting tubule system mediating the absorption of…”
Get full text

Regulation of vitamin D metabolizing enzymes in murine renal and extrarenal tissues by dietary phosphate, FGF23, and 1,25(OH)2D3 by Kägi, Larissa, Bettoni, Carla, Pastor-Arroyo, Eva M, Schnitzbauer, Udo, Hernando, Nati, Wagner, Carsten A

“…The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) together with parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) regulates calcium (Ca2+) and…”
Get full text

Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia by Schlingmann, Karl P, Ruminska, Justyna, Kaufmann, Martin, Dursun, Ismail, Patti, Monica, Kranz, Birgitta, Pronicka, Ewa, Ciara, Elzbieta, Akcay, Teoman, Bulus, Derya, Cornelissen, Elisabeth A M, Gawlik, Aneta, Sikora, Przemysław, Patzer, Ludwig, Galiano, Matthias, Boyadzhiev, Veselin, Dumic, Miroslav, Vivante, Asaf, Kleta, Robert, Dekel, Benjamin, Levtchenko, Elena, Bindels, René J, Rust, Stephan, Forster, Ian C, Hernando, Nati, Jones, Glenville, Wagner, Carsten A, Konrad, Martin

“…Idiopathic infantile hypercalcemia (IIH) is characterized by severe hypercalcemia with failure to thrive, vomiting, dehydration, and nephrocalcinosis…”
Get full text

The SLC34 family of sodium-dependent phosphate transporters by Wagner, Carsten A., Hernando, Nati, Forster, Ian C., Biber, Jürg

“…The SLC34 family of sodium-driven phosphate cotransporters comprises three members: NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3). These…”
Get full text

Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men by Daryadel, Arezoo, Bettoni, Carla, Haider, Thomas, Imenez Silva, Pedro H., Schnitzbauer, Udo, Pastor-Arroyo, Eva Maria, Wenger, Roland H., Gassmann, Max, Wagner, Carsten A.

“…Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate and 1,25 (OH) 2 vitamin D 3 metabolism and is mainly produced by osteocytes…”
Get full text

Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional study by Pavik, Ivana, Jaeger, Philippe, Ebner, Lena, Wagner, Carsten A, Petzold, Katja, Spichtig, Daniela, Poster, Diane, Wüthrich, Rudolf P, Russmann, Stefan, Serra, Andreas L

“…Klotho and fibroblast growth factor 23 (FGF23) are key regulators of mineral metabolism in renal insufficiency. FGF23 levels have been shown to increase early…”
Get full text

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice by Frebel, Helge, Nindl, Veronika, Schuepbach, Reto A, Braunschweiler, Thomas, Richter, Kirsten, Vogel, Johannes, Wagner, Carsten A, Loffing-Cueni, Dominique, Kurrer, Michael, Ludewig, Burkhard, Oxenius, Annette

“…The inhibitory programmed death 1 (PD-1)-programmed death ligand 1 (PD-L1) pathway contributes to the functional down-regulation of T cell responses during…”
Get full text

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability by King, Andrew J, Siegel, Matthew, He, Ying, Nie, Baoming, Wang, Ji, Koo-McCoy, Samantha, Minassian, Natali A, Jafri, Qumber, Pan, Deng, Kohler, Jill, Kumaraswamy, Padmapriya, Kozuka, Kenji, Lewis, Jason G, Dragoli, Dean, Rosenbaum, David P, O'Neill, Debbie, Plain, Allein, Greasley, Peter J, Jönsson-Rylander, Ann-Cathrine, Karlsson, Daniel, Behrendt, Margareta, Strömstedt, Maria, Ryden-Bergsten, Tina, Knöpfel, Thomas, Pastor Arroyo, Eva M, Hernando, Nati, Marks, Joanne, Donowitz, Mark, Wagner, Carsten A, Alexander, R Todd, Caldwell, Jeremy S

“…Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly associated with poor clinical outcomes. Current management of…”
Get more information

Regulation and function of the SLC38A3/SNAT3 glutamine transporter by Rubio-Aliaga, Isabel, Wagner, Carsten A.

Get full text

Acute Adaption to Oral or Intravenous Phosphate Requires Parathyroid Hormone by Thomas, Linto, Bettoni, Carla, Knöpfel, Thomas, Hernando, Nati, Biber, Jürg, Wagner, Carsten A

“…Phosphate (Pi) homeostasis is regulated by renal, intestinal, and endocrine mechanisms through which Pi intake stimulates parathyroid hormone (PTH) and…”
Get full text

The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function by Haykir, Betül, Moser, Seraina Olivia, Pastor-Arroyo, Eva Maria, Schnitzbauer, Udo, Radvanyi, Zsuzsa, Prucker, Isabel, Qiu, Danye, Fiedler, Dorothea, Saiardi, Adolfo, Jessen, Henning J, Hernando, Nati, Wagner, Carsten A

“…Kidneys are gatekeepers of systemic inorganic phosphate balance because they control urinary phosphate excretion. In yeast and plants, inositol…”
Get more information

Molecular Pathophysiology of Acid-Base Disorders by Wagner, Carsten A., Imenez Silva, Pedro H., Bourgeois, Soline

“…Acid-base balance is critical for normal life. Acute and chronic disturbances impact cellular energy metabolism, endocrine signaling, ion channel activity,…”
Get full text

Up-regulation of FGF23 release by aldosterone by Zhang, Bingbing, Umbach, Anja T., Chen, Hong, Yan, Jing, Fakhri, Hajar, Fajol, Abul, Salker, Madhuri S., Spichtig, Daniela, Daryadel, Arezoo, Wagner, Carsten A., Föller, Michael, Lang, Florian

“…The fibroblast growth factor (FGF23) plasma level is high in cardiac and renal failure and is associated with poor clinical prognosis of these disorders. Both…”
Get full text

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia by STUIVER, Marchel, LAINEZ, Sergio, QUERFELD, Uwe, WILLNOW, Thomas E, NEMEC, Vladimir, WAGNER, Carsten A, HOENDEROP, Joost G, DEVUYST, Olivier, KNOERS, Nine V. A. M, BINDELS, René J, MEIJ, Iwan C, MÜLLER, Dominik, WILL, Constanze, TERRYN, Sara, GÜNZEL, Dorothee, DEBAIX, Huguette, SOMMER, Kerstin, KOPPLIN, Kathrin, THUMFART, Julia, KAMPIK, Nicole B

“…Familial hypomagnesemia is a rare human disorder caused by renal or intestinal magnesium (Mg(2+)) wasting, which may lead to symptoms of Mg(2+) depletion such…”
Get full text

Phosphate Homeostasis, Inflammation and the Regulation of FGF-23 by Lang, Florian, Leibrock, Christina, Pandyra, Aleksandra A., Stournaras, Christos, Wagner, Carsten A., Föller, Michael

“…Fibroblast growth factor 23 (FGF23) is released primarily from osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho, FGF23 is a…”
Get full text

Regulated acid–base transport in the collecting duct by Wagner, Carsten A., Devuyst, Olivier, Bourgeois, Soline, Mohebbi, Nilufar

“…The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-secretory type-A intercalated cells secrete protons via a luminally…”
Get full text