Search Results - "Wagley, Pravin K"

Acute seizure activity in neonatal inflammation-sensitized hypoxia-ischemia in mice by June, Angelina, Matysik, Weronika, Marlicz, Maria, Zucker, Emily, Wagley, Pravin K, Kuan, Chia-Yi, Burnsed, Jennifer

“…To examine acute seizure activity and neuronal damage in a neonatal mouse model of inflammation-sensitized hypoxic-ischemic (IS-HI) brain injury utilizing…”
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Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death by Wenker, Ian C, Blizzard, Elizabeth A, Wagley, Pravin K, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are unknown, one…”
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Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy by Wengert, Eric R, Wenker, Ian C, Wagner, Elizabeth L, Wagley, Pravin K, Gaykema, Ronald P, Shin, Jung-Bum, Patel, Manoj K

“…Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies…”
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A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat by Grosenbaugh, Denise K., Joshi, Suchitra, Fitzgerald, Mark P., Lee, Kevin S., Wagley, Pravin K., Koeppel, Alexander F., Turner, Stephen D., McConnell, Michael J., Goodkin, Howard P.

“…Children with malformations of cortical development (MCD) are at risk for epilepsy, developmental delays, behavioral disorders, and intellectual disabilities…”
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Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy by Thompson, Jeremy A., Miralles, Raquel M., Wengert, Eric R., Wagley, Pravin K., Yu, Wenxi, Wenker, Ian C., Patel, Manoj K.

“…Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder…”
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Neuronal Circuit Activity during Neonatal Hypoxic–Ischemic Seizures in Mice by Burnsed, Jennifer, Skwarzyńska, Daria, Wagley, Pravin K., Isbell, Laura, Kapur, Jaideep

“…Objective To identify circuits active during neonatal hypoxic–ischemic (HI) seizures and seizure propagation using electroencephalography (EEG), behavior, and…”
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Prominent role of forebrain excitatory neurons in SCN8A encephalopathy by Bunton-Stasyshyn, Rosie K A, Wagnon, Jacy L, Wengert, Eric R, Barker, Bryan S, Faulkner, Alexa, Wagley, Pravin K, Bhatia, Kritika, Jones, Julie M, Maniaci, Marissa R, Parent, Jack M, Goodkin, Howard P, Patel, Manoj K, Meisler, Miriam H

“…Mutations in neuronal sodium channels cause neurodevelopmental disorders and epilepsy. Bunton-Stasyshyn et al. develop a mouse model with conditional…”
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Opto‐ and Chemogenetic Dissection of Ictal Apnea Neural Circuitry by Wenker, Ian C., Wagley, Pravin K., Boscia, Alexis R., Lewis, Christine, Patel, Manoj K.

“…Sudden Unexpected Death in Epilepsy (SUDEP) is defined as the sudden, unexpected and unexplained death of a person with epilepsy and accounts for between 8 and…”
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Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome by Wengert, Eric R., Wagley, Pravin K., Strohm, Samantha M., Reza, Nuha, Wenker, Ian C., Gaykema, Ronald P., Christiansen, Anne, Liau, Gene, Patel, Manoj K.

“…[Display omitted] •STK-001 treatment reduces seizures in a mouse model of Dravet Syndrome.•STK-001 prolongs survival in a mouse model of Dravet…”
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Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice by Wagley, Pravin K, Williamson, John, Skwarzynska, Daria, Kapur, Jaideep, Burnsed, Jennifer

“…Hypoxia ischemia is the most common cause of neonatal seizures. Animal models are crucial for understanding the mechanisms and physiology underlying neonatal…”
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Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy by Wenker, Ian C., Teran, Frida A., Wengert, Eric R., Wagley, Pravin K., Panchal, Payal S., Blizzard, Elizabeth A., Saraf, Priyanka, Wagnon, Jacy L., Goodkin, Howard P., Meisler, Miriam H., Richerson, George B., Patel, Manoj K.

“…Objective Sudden unexpected death in epilepsy (SUDEP) is an unpredictable and devastating comorbidity of epilepsy that is believed to be due to…”
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Somatostatin-Positive Interneurons Contribute to Seizures in SCN8A Epileptic Encephalopathy by Wengert, Eric R, Miralles, Raquel M, Wedgwood, Kyle C A, Wagley, Pravin K, Strohm, Samantha M, Panchal, Payal S, Idrissi, Abrar Majidi, Wenker, Ian C, Thompson, Jeremy A, Gaykema, Ronald P, Patel, Manoj K

“…epileptic encephalopathy is a devastating epilepsy syndrome caused by mutant , which encodes the voltage-gated sodium channel Na 1.6. To date, it is unclear if…”
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Acute seizure activity in neonatal inflammation-sensitized hypoxia-ischemia in mice by Angelina June, Weronika Matysik, Maria Marlicz, Emily Zucker, Pravin K. Wagley, Chia-Yi Kuan, Jennifer Burnsed

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