Search Results - "Waget, Aurélie"

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice by CANI, Patrice D, BIBILONI, Rodrigo, KNAUF, Claude, WAGET, Aurélie, NEYRINCK, Audrey M, DELZENNE, Nathalie M, BURCELIN, Rémy

“…Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice Patrice D. Cani 1 2 ,…”
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Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice by Riant, Elodie, Waget, Aurélie, Cogo, Haude, Arnal, Jean-François, Burcelin, Rémy, Gourdy, Pierre

“…Although corroborating data indicate that estrogens influence glucose metabolism through the activation of the estrogen receptor α (ERα), it has not been…”
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance by CANI, Patrice D, AMAR, Jacques, WAGET, Aurélie, DELMEE, Evelyne, COUSIN, Beatrice, SULPICE, Thierry, CHAMONTIN, Bernard, FERRIERES, Jean, TANTI, Jean-Francois, GIBSON, Glenn R, CASTEILLA, Louis, DELZENNE, Nathalie M, IGLESIAS, Miguel Angel, ALESSI, Marie Christine, BURCELIN, Rémy, POGGI, Marjorie, KNAUF, Claude, BASTELICA, Delphine, NEYRINCK, Audrey M, FAVA, Francesca, TUOHY, Kieran M, CHABO, Chantal

“…Metabolic Endotoxemia Initiates Obesity and Insulin Resistance Patrice D. Cani 1 2 , Jacques Amar 3 , Miguel Angel Iglesias 1 , Marjorie Poggi 4 , Claude Knauf…”
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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis by Sebastián, David, Hernández-Alvarez, María Isabel, Segalés, Jessica, Sorianello, Eleonora, Muñoz, Juan Pablo, Sala, David, Waget, Aurélie, Liesa, Marc, Paz, José C, Gopalacharyulu, Peddinti, Orešič, Matej, Pich, Sara, Burcelin, Rémy, Palacín, Manuel, Zorzano, Antonio

“…Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly…”
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Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response by Blasco-Baque, Vincent, Garidou, Lucile, Pomié, Céline, Escoula, Quentin, Loubieres, Pascale, Le Gall-David, Sandrine, Lemaitre, Mathieu, Nicolas, Simon, Klopp, Pascale, Waget, Aurélie, Azalbert, Vincent, Colom, André, Bonnaure-Mallet, Martine, Kemoun, Philippe, Serino, Matteo, Burcelin, Rémy

“…To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched…”
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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment by Amar, Jacques, Chabo, Chantal, Waget, Aurélie, Klopp, Pascale, Vachoux, Christelle, Bermúdez‐Humarán, Luis G., Smirnova, Natalia, Bergé, Mathieu, Sulpice, Thierry, Lahtinen, Sampo, Ouwehand, Arthur, Langella, Philippe, Rautonen, Nina, Sansonetti, Philippe J., Burcelin, Rémy

“…A fat‐enriched diet modifies intestinal microbiota and initiates a low‐grade inflammation, insulin resistance and type‐2 diabetes. Here, we demonstrate that…”
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The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease by Garidou, Lucile, Pomié, Céline, Klopp, Pascale, Waget, Aurélie, Charpentier, Julie, Aloulou, Meryem, Giry, Anaïs, Serino, Matteo, Stenman, Lotta, Lahtinen, Sampo, Dray, Cedric, Iacovoni, Jason S., Courtney, Michael, Collet, Xavier, Amar, Jacques, Servant, Florence, Lelouvier, Benjamin, Valet, Philippe, Eberl, Gérard, Fazilleau, Nicolas, Douin-Echinard, Victorine, Heymes, Christophe, Burcelin, Rémy

“…A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown…”
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Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass by Girousse, Amandine, Tavernier, Geneviève, Valle, Carine, Moro, Cedric, Mejhert, Niklas, Dinel, Anne-Laure, Houssier, Marianne, Roussel, Balbine, Besse-Patin, Aurèle, Combes, Marion, Mir, Lucile, Monbrun, Laurent, Bézaire, Véronic, Prunet-Marcassus, Bénédicte, Waget, Aurélie, Vila, Isabelle, Caspar-Bauguil, Sylvie, Louche, Katie, Marques, Marie-Adeline, Mairal, Aline, Renoud, Marie-Laure, Galitzky, Jean, Holm, Cecilia, Mouisel, Etienne, Thalamas, Claire, Viguerie, Nathalie, Sulpice, Thierry, Burcelin, Rémy, Arner, Peter, Langin, Dominique

“…When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in peripheral tissues via stimulation of fat cell lipolysis. FAs have been…”
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Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing by KNAUF, Claude, CANI, Patrice D, SEELEY, Randy J, BURCELIN, Remy, KIM, Dong-Hoon, IGLESIAS, Miguel A, CHABO, Chantal, WAGET, Aurélie, COLOM, André, RASTRELLI, Sophie, DELZENNE, Nathalie M, DRUCKER, Daniel J

“…Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing Claude Knauf 1 , Patrice D. Cani 1 2 , Dong-Hoon Kim 3 , Miguel A…”
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Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control by Dao, Thi-Mai Anh, Waget, Aurélie, Klopp, Pascale, Serino, Matteo, Vachoux, Christelle, Pechere, Laurent, Drucker, Daniel J, Champion, Serge, Barthélemy, Sylvain, Barra, Yves, Burcelin, Rémy, Sérée, Eric

“…Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV…”
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Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice by Waget, Aurélie, Cabou, Cendrine, Masseboeuf, Myriam, Cattan, Pierre, Armanet, Mattieu, Karaca, Mélis, Castel, Julien, Garret, Celine, Payros, Gaëlle, Maida, Adriano, Sulpice, Thierry, Holst, Jens J, Drucker, Daniel J, Magnan, Christophe, Burcelin, Rémy

“…Inhibition of dipeptidyl peptidase-4 (DPP-4) activity improves glucose homeostasis through a mode of action related to the stabilization of the active forms of…”
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Liraglutide targets the gut microbiota and the intestinal immune system to regulate insulin secretion by Charpentier, Julie, Briand, Francois, Lelouvier, Benjamin, Servant, Florence, Azalbert, Vincent, Puel, Anthony, Christensen, Jeffrey E., Waget, Aurélie, Branchereau, Maxime, Garret, Céline, Lluch, Jérome, Heymes, Christophe, Brousseau, Emmanuel, Burcelin, Rémy, Guzylack, Laurence, Sulpice, Thierry, Grasset, Estelle

“…Aims Liraglutide controls type 2 diabetes (T2D) and inflammation. Gut microbiota regulates the immune system and causes at least in part type 2 diabetes. We…”
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Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice by Dray, Cédric, Knauf, Claude, Daviaud, Danièle, Waget, Aurélie, Boucher, Jérémie, Buléon, Marie, Cani, Patrice D., Attané, Camille, Guigné, Charlotte, Carpéné, Christian, Burcelin, Rémy, Castan-Laurell, Isabelle, Valet, Philippe

“…Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and potentially link obesity to insulin resistance. Apelin, a peptide…”
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Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice by Nohara, Kazunari, Waraich, Rizwana S, Liu, Suhuan, Ferron, Mathieu, Waget, Aurélie, Meyers, Matthew S, Karsenty, Gérard, Burcelin, Rémy, Mauvais-Jarvis, Franck

“…Among women, the polycystic ovarian syndrome (PCOS) is considered a form of metabolic syndrome with reproductive abnormalities. Women with PCOS show increased…”
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CX3CR1 regulates gut microbiota and metabolism. A risk factor of type 2 diabetes by Pomié, Celine, Servant, Florence, Garidou, Lucile, Azalbert, Vincent, Waget, Aurélie, Klopp, Pascale, Garret, Céline, Charpentier, Julie, Briand, Francois, Sulpice, Thierry, Lelouvier, Benjamin, Douin-Echinard, Victorine, Burcelin, Rémy

“…Objective The intestinal microbiota to immune system crosstalk is a major regulator of metabolism and hence metabolic diseases. An impairment of the chemokine…”
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Brain Glucagon-Like Peptide 1 Signaling Controls the Onset of High-Fat Diet-Induced Insulin Resistance and Reduces Energy Expenditure by Knauf, Claude, Cani, Patrice D, Ait-Belgnaoui, Afifa, Benani, Alexandre, Dray, Cédric, Cabou, Cendrine, Colom, André, Uldry, Marc, Rastrelli, Sophie, Sabatier, Eric, Godet, Natacha, Waget, Aurélie, Pénicaud, Luc, Valet, Philippe, Burcelin, Rémy

“…Glucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the brain. We previously demonstrated that brain GLP-1 increases glucose-dependent…”
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Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease by Luche, Elodie, Robert, Virginie, Cuminetti, Vincent, Pomié, Celine, Sastourné-Arrey, Quentin, Waget, Aurélie, Arnaud, Emmanuelle, Varin, Audrey, Labit, Elodie, Laharrague, Patrick, Burcelin, Remy, Casteilla, Louis, Cousin, Beatrice

“…Activation and increased numbers of inflammatory macrophages, in adipose tissue (AT) are deleterious in metabolic diseases. Up to now, AT macrophages (ATM)…”
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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B by Gomez, Elodie, Vercauteren, Magali, Kurtz, Baptiste, Ouvrard-Pascaud, Antoine, Mulder, Paul, Henry, Jean-Paul, Besnier, Marie, Waget, Aurélie, Hooft Van Huijsduijnen, Rob, Tremblay, Michel L, Burcelin, Remy, Thuillez, Christian, Richard, Vincent

“…Abstract Protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase receptor-mediated responses, and especially negatively influences insulin…”
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Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia by Pomié, Céline, Blasco-Baque, Vincent, Klopp, Pascale, Nicolas, Simon, Waget, Aurélie, Loubières, Pascale, Azalbert, Vincent, Puel, Anthony, Lopez, Frédéric, Dray, Cédric, Valet, Philippe, Lelouvier, Benjamin, Servant, Florence, Courtney, Michael, Amar, Jacques, Burcelin, Rémy, Garidou, Lucile

“…Abstract Objective To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota…”
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Periodontal dysbiosis linked to periodontitis is associated with cardiometabolic adaptation to high-fat diet in mice by Branchereau, Maxime, Reichardt, François, Loubieres, Pascale, Marck, Pauline, Waget, Aurélie, Azalbert, Vincent, Colom, André, Padmanabhan, Roshan, Iacovoni, Jason S, Giry, Anaïs, Tercé, François, Heymes, Christophe, Burcelin, Remy, Serino, Matteo, Blasco-Baque, Vincent

“…Periodontitis and type 2 diabetes are connected pandemic diseases, and both are risk factors for cardiovascular complications. Nevertheless, the molecular…”
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