Search Results - "Wagenknecht, Terence"

Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM by Samsó, Montserrat, Wagenknecht, Terence, Allen, P D

“…RyR1 is an intracellular calcium channel with a central role in muscle contraction. We obtained a three-dimensional reconstruction of the RyR1 in the closed…”
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Initial bridges between two ribosomal subunits are formed within 9.4 milliseconds, as studied by time-resolved cryo-EM by Shaikh, Tanvir R., Yassin, Aymen S., Lu, Zonghuan, Barnard, David, Meng, Xing, Lu, Toh-Ming, Wagenknecht, Terence, Agrawal, Rajendra K.

“…Association of the two ribosomal subunits during the process of translation initiation is a crucial step of protein synthesis. The two subunits (30S and 50S)…”
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Apocalmodulin and Ca2+-Calmodulin Bind to Neighboring Locations on the Ryanodine Receptor by Montserrat SamsÃ, Terence Wagenknecht

“…Calmodulin (CaM) binds to the ryanodine receptor/calcium release channel of skeletal muscle (RyR1), both in the absence and presence of Ca 2+ , and regulates…”
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Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor by Wang, Ruiwu, Zhong, Xiaowei, Meng, Xing, Koop, Andrea, Tian, Xixi, Jones, Peter P., Fruen, Bradley R., Wagenknecht, Terence, Liu, Zheng, Chen, S.R. Wayne

“…Dantrolene is believed to stabilize interdomain interactions between the NH2-terminal and central regions of ryanodine receptors by binding to the NH2-terminal…”
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Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain by Huang, Xiaojun, Liu, Ying, Wang, Ruiwu, Zhong, Xiaowei, Liu, Yingjie, Koop, Andrea, Chen, S R Wayne, Wagenknecht, Terence, Liu, Zheng

“…Calmodulin (CaM), a 16 kDa ubiquitous calcium-sensing protein, is known to bind tightly to the calcium release channel/ryanodine receptor (RyR), and modulate…”
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Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor by Liu, Zheng, Wang, Ruiwu, Tian, Xixi, Zhong, Xiaowei, Gangopadhyay, Jaya, Cole, Richard, Ikemoto, Noriaki, Chen, S.R. Wayne, Wagenknecht, Terence

“…Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been linked to certain types of cardiac arrhythmias and sudden death. Two mutation…”
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Localization of an NH2-terminal Disease-causing Mutation Hot Spot to the “Clamp” Region in the Three-dimensional Structure of the Cardiac Ryanodine Receptor by Wang, Ruiwu, Chen, Wenqian, Cai, Shitian, Zhang, Jing, Bolstad, Jeff, Wagenknecht, Terence, Liu, Zheng, Chen, S. R. Wayne

“…A region between residues 414 and 466 in the cardiac ryanodine receptor (RyR2) harbors more than half of the known NH2-terminal mutations associated with…”
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Structural and Functional Characterization of Ryanodine Receptor-Natrin Toxin Interaction by Zhou, Qiang, Wang, Qiong-Ling, Meng, Xing, Shu, Yuyan, Jiang, Tao, Wagenknecht, Terence, Yin, Chang-Cheng, Sui, Sen-Fang, Liu, Zheng

“…Cysteine-rich secretory proteins (CRISPs) are widely distributed, and notably occur in the mammalian reproductive tract and in the salivary glands of venomous…”
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CLIC2-RyR1 Interaction and Structural Characterization by Cryo-electron Microscopy by Meng, Xing, Wang, Guoliang, Viero, Cedric, Wang, Qiongling, Mi, Wei, Su, Xiao-Dong, Wagenknecht, Terence, Williams, Alan J., Liu, Zheng, Yin, Chang-Cheng

“…Chloride intracellular channel 2 (CLIC2), a newly discovered small protein distantly related to the glutathione transferase (GST) structural family, is highly…”
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Three-Dimensional Localization of Serine 2808, a Phosphorylation Site in Cardiac Ryanodine Receptor by Meng, Xing, Xiao, Bailong, Cai, Shitian, Huang, Xiaojun, Li, Fei, Bolstad, Jeff, Trujillo, Ramon, Airey, Judith, Chen, S.R. Wayne, Wagenknecht, Terence, Liu, Zheng

“…Type 2 ryanodine receptor (RyR2) is the major calcium release channel in cardiac muscle. Phosphorylation of RyR2 by cAMP-dependent protein kinase A and by…”
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Skeletal muscle triad junction ultrastructure by Focused-Ion-Beam milling of muscle and Cryo-Electron Tomography by Wagenknecht, Terence, Hsieh, Chyongere, Marko, Michael

“…Cryo-electron tomography (cryo-ET) has emerged as perhaps the only practical technique for revealing nanometer-level three-dimensional structural details of…”
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Localization of a Disease-associated Mutation Site in the Three-dimensional Structure of the Cardiac Muscle Ryanodine Receptor by Liu, Zheng, Wang, Ruiwu, Zhang, Jing, Chen, S.R. Wayne, Wagenknecht, Terence

“…The cardiac muscle ryanodine receptor (RyR2) functions as a calcium release channel in the heart. Up to 40 mutations in RyR2 have been linked to genetic forms…”
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Electron Microscopy of Ryanodine Receptors by Wagenknecht, Terence C., Liu, Zheng

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Three-Dimensional Visualization of FKBP12.6 Binding to an Open Conformation of Cardiac Ryanodine Receptor by Sharma, Manjuli Rani, Jeyakumar, Loice H., Fleischer, Sidney, Wagenknecht, Terence

“…The cardiac isoform of the ryanodine receptor (RyR2) from dog binds predominantly a 12.6-kDa isoform of the FK506-binding protein (FKBP12.6), whereas RyR2 from…”
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Three-dimensional Localization of Divergent Region 3 of the Ryanodine Receptor to the Clamp-shaped Structures Adjacent to the FKBP Binding Sites by Zhang, Jing, Liu, Zheng, Masumiya, Haruko, Wang, Ruiwu, Jiang, Dawei, Li, Fei, Wagenknecht, Terence, Chen, S. R. Wayne

“…Of the three divergent regions of ryanodine receptors (RyRs), divergent region 3 (DR3) is the best studied and is believed to be involved in…”
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Three-dimensional Reconstruction of the Recombinant Type 2 Ryanodine Receptor and Localization of Its Divergent Region 1 by Liu, Zheng, Zhang, Jing, Li, Pin, Chen, S R Wayne, Wagenknecht, Terence

“…Isoform 2 of the ryanodine receptor (RyR2) is the major calcium release channel in cardiac muscle. In the present study, two kinds of RyR2 cDNA were…”
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Locations of Calmodulin and FK506-binding Protein on the Three-dimensional Architecture of the Skeletal Muscle Ryanodine Receptor by Wagenknecht, Terence, Radermacher, Michael, Grassucci, Robert, Berkowitz, Jon, Xin, Hong-Bo, Fleischer, Sidney

“…Isolated skeletal muscle ryanodine receptors (RyRs) complexed with the modulatory ligands, calmodulin (CaM) or 12-kDa FK506-binding protein (FKBP12), have been…”
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Three-dimensional Structure of Ryanodine Receptor Isoform Three in Two Conformational States as Visualized by Cryo-electron Microscopy by Sharma, Manjuli R., Jeyakumar, Loice H., Fleischer, Sidney, Wagenknecht, Terence

“…Using cryo-electron microscopy and single particle image processing techniques, we present the first three-dimensional reconstructions of isoform 3 of the…”
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Three-Dimensional Reconstruction of the Recombinant Type 3 Ryanodine Receptor and Localization of Its Amino Terminus by Liu, Zheng, Zhang, Jing, Sharma, Manjuli R., Li, Pin, S. R. Wayne Chen, Wagenknecht, Terence

“…Recombinant type 3 ryanodine receptor (RyR3) has been purified in quantities sufficient for structural characterization by cryoelectron microscopy and…”
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Three-Dimensional Location of the Imperatoxin A Binding Site on the Ryanodine Receptor by Samsó, Montserrat, Trujillo, Ramon, Gurrola, Georgina B., Valdivia, Hector H., Wagenknecht, Terence

“…Cryo-electron microscopy and three-dimensional, single-particle image analysis have been used to reveal the specific binding site of imperatoxin A ( IpTx a) on…”
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