Search Results - "Wagener, M. E."

Integrin Antagonists Prevent Costimulatory Blockade‐Resistant Transplant Rejection by CD8+ Memory T Cells by Kitchens, W. H., Haridas, D., Wagener, M. E., Song, M., Kirk, A. D., Larsen, C. P., Ford, M. L.

“…The success of belatacept in late‐stage clinical trials inaugurates the arrival of a new class of immunosuppressants based on costimulatory blockade, an…”
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An Anti‐CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA‐4 Ig by Pinelli, D. F., Wagener, M. E., Liu, D., Yamniuk, A., Tamura, J., Grant, S., Larsen, C. P., Suri, A., Nadler, S. G., Ford, M. L.

“…The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but…”
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Pathogen Stimulation History Impacts Donor‐Specific CD8+ T Cell Susceptibility to Costimulation/Integrin Blockade–Based Therapy by Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A. E., Larsen, C. P., Ford, M. L.

“…Recent studies have shown that the quantity of donor‐reactive memory T cells is an important factor in determining the relative heterologous immunity barrier…”
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Rapamycin ameliorates the CTLA4‐Ig–mediated defect in CD8+ T cell immunity during gammaherpesvirus infection by Pinelli, D. F., Wakeman, B. S., Wagener, M. E., Speck, S. H., Ford, M. L.

“…Latent viral infections are a major concern among immunosuppressed transplant patients. During clinical trials with belatacept, a CTLA4‐Ig fusion protein,…”
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Selective CD28 Blockade Results in Superior Inhibition of Donor‐Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4‐Ig by Badell, I. R., La Muraglia, G. M., Liu, D., Wagener, M. E., Ding, G., Ford, M. L.

“…Donor‐specific antibodies (DSAs) are a barrier to improved long‐term outcomes after kidney transplantation. Costimulation blockade with CTLA4‐Ig has shown…”
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Antigenic Disparity Impacts Outcome of Agonism but Not Blockade of Costimulatory Pathways in Experimental Transplant Models by Ford, M. L., Wagener, M. E., Gangappa, S., Pearson, T. C., Larsen, C. P.

“…Treatment regimens consisting of CTLA‐4 Ig/anti‐CD154 or agonistic anti‐CD28/rapamycin have both been shown to prevent GVHD in fully allogeneic murine model…”
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Failure to Induce Neonatal Tolerance in Mice That Lack Both IL-4 and IL-13 but Not in Those That Lack IL-4 Alone by Inoue, Yoshihiko, Konieczny, Bogumila T, Wagener, Maylene E, McKenzie, Andrew N. J, Lakkis, Fadi G

“…Current evidence suggests that neonatal tolerance to a foreign Ag is the consequence of IL-4-mediated Th2 immunity rather than the thymic deletion of…”
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Alloantigen-driven T cell death mediated by fas ligand and tumor necrosis factor-α is not essential for the induction of allograft acceptance by WAGENER, M. E, KONIECZNY, B. T, ZHENHUA DAI, RING, G. H, LAKKIS, F. G

“…Fas ligand (FasL)-Fas and tumor necrosis factor alpha (TNFalpha)-tumor necrosis factor receptor (TNFR) interactions regulate immune responses and contribute to…”
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Emery-Dreifuss muscular dystrophy by Zacharias, A S, Wagener, M E, Warren, S T, Hopkins, L C

“…Emery-Dreifuss muscular dystrophy (EDMD) is the third most common X-linked muscular dystrophy. This disorder is characterized by childhood onset of early…”
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Selective CD28 blockade results in superior inhibition of donor-specific T follicular helper cell and antibody responses relative to CTLA-4-Ig by Badell, IR, La Muraglia, GM, Liu, D, Wagener, ME, Ding, G, Ford, ML

“…Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown…”
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Combined Costimulatory and Leukocyte Functional Antigen-1 Blockade Prevents Transplant Rejection Mediated by Heterologous Immune Memory Alloresponses by KITCHENS, William H, HARIDAS, Divya, WAGENER, Maylene E, MINGQING SONG, FORD, Mandy L

“…Recent evidence suggests that alloreactive memory T cells are generated by the process of heterologous immunity, whereby memory T cells arising in response to…”
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High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade by Floyd, Tamara L, Orr, Steven B, Coley, Shana M, Hanna, Samantha S, Wagener, Maylene E, Kirk, Allan D, Larsen, Christian P, Ford, Mandy L

“…Blockade of costimulatory molecules is a potent method of inducing long-term graft survival. We have previously addressed the issue of donor-reactive T-cell…”
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