Search Results - "Wagenaar, Gerry"

Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells by Li, Meng, van Esch, Betty C.A.M., Wagenaar, Gerry T.M., Garssen, Johan, Folkerts, Gert, Henricks, Paul A.J.

“…In the gastro-intestinal tract, short chain fatty acids (SCFAs) have protective effects on epithelial cells. However, their effects on inflammatory cytokine…”
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Evolving views on the first two ligands of the angiotensin II type 2 receptor. From putative antagonists to potential agonists? by Wagenaar, Gerry T M, Moll, Gert N

“…The renin-angiotensin system is one of the most complex regulatory systems that controls multiple organ functions. One of its key components, angiotensin II…”
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Vascular and pulmonary effects of ibuprofen on neonatal lung development by Chen, Xueyu, Han, Dongshan, Wang, Xuan, Huang, Xuemei, Huang, Zilu, Liu, Yijun, Zhong, Junyan, Walther, Frans J, Yang, Chuanzhong, Wagenaar, Gerry T M

“…Ibuprofen is a nonsteroidal anti-inflammatory drug that is commonly used to stimulate closure of a patent ductus arteriosus (PDA) in very premature infants and…”
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Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation? by Overbeek, Saskia A, Braber, Saskia, Koelink, Pim J, Henricks, Paul A J, Mortaz, Esmaeil, LoTam Loi, Adele T, Jackson, Patricia L, Garssen, Johan, Wagenaar, Gerry T M, Timens, Wim, Koenderman, Leo, Blalock, J Edwin, Kraneveld, Aletta D, Folkerts, Gert

“…Cigarette smoking induces inflammatory responses in all smokers and is the major risk factor for lung disease such as chronic obstructive pulmonary disease…”
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Inhibition of lysophosphatidic acid receptor 2 attenuates neonatal chronic lung disease in mice by preserving vascular and alveolar development by Chen, Xueyu, Han, Dongshan, Zeng, Yali, Li, Huitao, Wang, Xuan, Huang, Zilu, Yang, Lingling, Wagenaar, Gerry T.M., Lin, Bingchun, Yang, Chuanzhong

“…Bronchopulmonary dysplasia (BPD) is a common morbidity in extremely premature infants. Previous studies demonstrated the important role of lysophosphatidic…”
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Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury by de Visser, Yvonne P, Walther, Frans J, Laghmani, El Houari, Boersma, Hester, van der Laarse, Arnoud, Wagenaar, Gerry Tm

“…Phosphodiesterase-5 inhibition with sildenafil has been used to treat severe pulmonary hypertension and bronchopulmonary dysplasia (BPD), a chronic lung…”
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Apelin Attenuates Hyperoxic Lung and Heart Injury in Neonatal Rats by DE VISSER, Yvonne P, WALTHER, Frans J, EL HOUARI LAGHMANI, VAN DER LAARSE, Arnoud, WAGENAAR, Gerry T. M

“…Apelin, a potent vasodilator and angiogenic factor, may be a novel therapeutic agent in neonatal chronic lung disease, including bronchopulmonary dysplasia. To…”
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Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response by Chen, Xueyu, Walther, Frans J, Sengers, Rozemarijn M A, Laghmani, El Houari, Salam, Asma, Folkerts, Gert, Pera, Tonio, Wagenaar, Gerry T M

“…Because therapeutic options are lacking for bronchopulmonary dysplasia (BPD), there is an urgent medical need to discover novel targets/drugs to treat this…”
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Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils by Heestermans, Marco, Salloum-Asfar, Salam, Streef, Tom, Laghmani, El Houari, Salvatori, Daniela, Luken, Brenda M., Zeerleder, Sacha S., Spronk, Henri M.H., Korporaal, Suzanne J., Kirchhofer, Daniel, Wagenaar, Gerry T.M., Versteeg, Henri H., Reitsma, Pieter H., Renné, Thomas, van Vlijmen, Bart J.M.

“…Tissue factor, coagulation factor XII, platelets, and neutrophils are implicated as important players in the pathophysiology of (experimental) venous…”
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Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury by Wagenaar, Gerry T M, Laghmani, El Houari, Fidder, Melissa, Sengers, Rozemarijn M A, de Visser, Yvonne P, de Vries, Louwe, Rink, Rick, Roks, Anton J M, Folkerts, Gert, Walther, Frans J

“…Stimulation of MAS oncogene receptor (MAS) or angiotensin (Ang) receptor type 2 (AT2) may be novel therapeutic options for neonatal chronic lung disease (CLD)…”
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Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats by Wagenaar, Gerry T M, Sengers, Rozemarijn M A, Laghmani, El Houari, Chen, Xueyu, Lindeboom, Melissa P H A, Roks, Anton J M, Folkerts, Gert, Walther, Frans J

“…Intervening in angiotensin (Ang)-II type 2 receptor (AT2) signaling may have therapeutic potential for bronchopulmonary dysplasia (BPD) by attenuating lung…”
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Therapeutic potential of soluble guanylate cyclase modulators in neonatal chronic lung disease by Wagenaar, Gerry T M, Hiemstra, Pieter S, Gosens, Reinoud

“…Supplemental oxygen after premature birth results in aberrant airway, alveolar, and pulmonary vascular development with an increased risk for bronchopulmonary…”
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Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats by de Visser, Yvonne P, Walther, Frans J, Laghmani, El Houari, Steendijk, Paul, Middeldorp, Maaike, van der Laarse, Arnoud, Wagenaar, Gerry T M

“…Phosphodiesterase (PDE) 4 inhibitors are potent anti-inflammatory drugs with antihypertensive properties, and their therapeutic role in bronchopulmonary…”
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Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension by Umar, Soban, de Visser, Yvonne P, Steendijk, Paul, Schutte, Cindy I, Laghmani, El Houari, Wagenaar, Gerry T M, Bax, Wilhelmina H, Mantikou, Eleni, Pijnappels, Daniel A, Atsma, Douwe E, Schalij, Martin J, van der Wall, Ernst E, van der Laarse, Arnoud

“…Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular (RV) hypertrophy (RVH), remodeling, and failure. We tested…”
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Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats by Schouten, Laura R. A., Helmerhorst, Hendrik J. F., Wagenaar, Gerry T. M., Haltenhof, Tom, Lutter, René, Roelofs, Joris J. T. H., van Woensel, Job B. M., van Kaam, Anton H. L. C., Bos, Albert P., Schultz, Marcus J., Walther, Thomas, Wösten-van Asperen, Roelie M.

“…OBJECTIVES:A growing body of evidence suggests that age affects the main pathophysiologic mechanisms of the acute respiratory distress syndrome. This may imply…”
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Role of platelets, neutrophils, and factor XII in spontaneous venous thrombosis in mice by Heestermans, Marco, Salloum-Asfar, Salam, Salvatori, Daniela, Laghmani, El Houari, Luken, Brenda M., Zeerleder, Sacha S., Spronk, Henri M.H., Korporaal, Suzanne J., Wagenaar, Gerry T.M., Reitsma, Pieter H., van Vlijmen, Bart J.M.

“…Recently, platelets, neutrophils, and factor XII (FXII) have been implicated as important players in the pathophysiology of venous thrombosis. Their role…”
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Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation by Chen, Xueyu, Orriols, Mar, Walther, Frans J, Laghmani, El Houari, Hoogeboom, Annemarie M, Hogen-Esch, Anne C B, Hiemstra, Pieter S, Folkerts, Gert, Goumans, Marie-José T H, Ten Dijke, Peter, Morrell, Nicholas W, Wagenaar, Gerry T M

“…Effective treatment of premature infants with bronchopulmonary dysplasia (BPD) is lacking. We hypothesize that bone morphogenetic protein 9 (BMP9), a ligand of…”
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Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production by Safdar, Huma, Cheung, Ka Lei, Salvatori, Daniela, Versteeg, Henri H., Laghmani, El Houari, Wagenaar, Gerry T.M., Reitsma, Pieter H., van Vlijmen, Bart J.M.

“…Mice deficient in the anticoagulants antithrombin (Serpinc1) or protein C (Proc) display premature death due to thrombosis-related coagulopathy, thereby…”
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Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes by Helmerhorst, Hendrik J. F., Schouten, Laura R. A., Wagenaar, Gerry T. M., Juffermans, Nicole P., Roelofs, Joris J. T. H., Schultz, Marcus J., de Jonge, Evert, van Westerloo, David J.

“…Background Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time-…”
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Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat by Joustra, Sjoerd D, Meijer, Onno C, Heinen, Charlotte A, Mol, Isabel M, Laghmani, El Houari, Sengers, Rozemarijn M A, Carreno, Gabriela, van Trotsenburg, A S Paul, Biermasz, Nienke R, Bernard, Daniel J, Wit, Jan M, Oostdijk, Wilma, van Pelt, Ans M M, Hamer, Geert, Wagenaar, Gerry T M

“…Loss-of-function mutations in the immunoglobulin superfamily member 1 (IGSF1) gene cause an X-linked syndrome of central hypothyroidism, macroorchidism,…”
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