Search Results - "Waelbroeck, Magali"

Ghrelin Degradation by Serum and Tissue Homogenates: Identification of the Cleavage Sites by De Vriese, Carine, Gregoire, Francoise, Lema-Kisoka, Roger, Waelbroeck, Magali, Robberecht, Patrick, Delporte, Christine

“…The endogenous ligand for the GH secretagogue receptor is ghrelin, a peptide recently purified from the stomach. Ghrelin is n-octanoylated on the Ser3 residue,…”
Get full text

Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction by Wuest, Melinda, Weiss, Anke, Waelbroeck, Magali, Braeter, Manfred, Kelly, Lutz-Ullrich, Hakenberg, Oliver W, Ravens, Ursula

“…Propiverine is a commonly used antimuscarinic drug used as therapy for symptoms of an overactive bladder. Propiverine is extensively biotransformed into…”
Get full text

Two Basic Residues of the h-VPAC1 Receptor Second Transmembrane Helix Are Essential for Ligand Binding and Signal Transduction by Solano, Rosa Maria, Langer, Ingrid, Perret, Jason, Vertongen, Pascale, Juarranz, Maria Guillerma, Robberecht, Patrick, Waelbroeck, Magali

“…We mutated the vasoactive intestinal peptide (VIP) Asp3 residue and two VPAC1receptor second transmembrane helix basic residues (Arg188and Lys195). VIP had a…”
Get full text

In vitro properties of a high affinity selective antagonist of the VIP1 receptor by Gourlet, P, De Neef, P, Cnudde, J, Waelbroeck, M, Robberecht, P

“…A selective high affinity VIP1 receptor antagonist [Acetyl-His1, D-Phe2, Lys15, Arg16, Leu17] VIP(3-7)/GRF(8-27) or PG 97-269 was synthesized, by analogy with…”
Get full text

Development of high affinity selective VIP1 receptor agonists by Gourlet, P, Vandermeers, A, Vertongen, P, Rathe, J, De Neef, P, Cnudde, J, Waelbroeck, M, Robberecht, P

“…The biological effects of VIP are mediated by at least two VIP receptors: the VIP1 and the VIP2 receptors that were cloned in rat, human and mice. As the mRNA…”
Get full text

Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists by Gao, Ling-Jie, Waelbroeck, Magali, Hofman, Sven, Van Haver, Dirk, Milanesio, Marco, Viterbo, Davide, De Clercq, Pierre J

“…A series of himbacine ( 1)-related analogues has been prepared featuring three different isomeric configurations with respect to the B-ring ( a, b and natural…”
Get full text

Techniques: Promiscuous Gα proteins in basic research and drug discovery by Kostenis, Evi, Waelbroeck, Magali, Milligan, Graeme

“…Assay technologies that measure the activation of heterotrimeric (αβγ) G proteins by G-protein-coupled receptors (GPCRs) are well established within the…”
Get full text

Characterization of a novel VPAC1 selective agonist and identification of the receptor domains implicated in the carboxyl‐terminal peptide recognition by Van Rampelbergh, Jean, Juarranz, Maria‐Guillerma, Perret, Jason, Bondue, Antoine, Solano, Rosa Maria, Delporte, Christine, De Neef, Philippe, Robberecht, Patrick, Waelbroeck, Magali

“…Vasoactive Intestinal Polypeptide (VIP) interacts with a high affinity to two subclasses of G protein coupled receptors named VPAC1 and VPAC2, and has a 3–10…”
Get full text

DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops by van der Woning, Bas, De Boeck, Gitte, Blanchetot, Christophe, Bobkov, Vladimir, Klarenbeek, Alex, Saunders, Michael, Waelbroeck, Magali, Laeremans, Toon, Steyaert, Jan, Hultberg, Anna, De Haard, Hans

“…The identification of functional monoclonal antibodies directed against G-protein coupled receptors (GPCRs) is challenging because of the membrane-embedded…”
Get full text

Analysis of the glucagon receptor first extracellular loop by the substituted cysteine accessibility method by Roberts, David J., Vertongen, Pascale, Waelbroeck, Magali

“…[Display omitted] ► SCAM of the first glucagon receptor extracellular loop (197–224). ► TM2 continues to position 202, TM3 from 215 ► Most side chains…”
Get full text

Synthesis and binding affinity studies of muscarinic receptor antagonists related to dehydrohimbacine by Gao, Ling-Jie, Cauwenberge, Gunther Van, Hosten, Noël, Haver, Dirk Van, Waelbroeck, Magali, Clercq, Pierre J. De

Get full text

Properties of the VIP-PACAP type II receptor stably expressed in CHO cells by Ciccarelli, E, Vilardaga, J P, De Neef, P, Di Paolo, E, Waelbroeck, M, Bollen, A, Robberecht, P

“…The VIP receptor cloned from rat lung (VIP1 receptor from the group of the PACAP-VIP type II receptors) was inserted into a mammalian expression vector and…”
Get more information

Pharmacological discrimination between enantiomeric germanes by muscarinic receptors: a study on germanium/silicon bioisosterism by Tacke, Reinhold, Reichel, Dirk, Jones, Peter G., Hou, Xue, Waelbroeck, Magali, Gross, Jan, Mutschler, Ernst, Lambrecht, Günter

“…The (hydroxymethyl)diorgano(2-piperidinoethyl)germanes rac-Ph( c-Hex)Ge(CH 2OH)CH 2CH 2NR 2 ( rac- 1a), Ph 2Ge(CH 2OH)CH 2-CH 2NR 2 ( 3a) and ( c-Hex) 2Ge(CH…”
Get full text

Biological Recognition of Enantiomeric Silanes: Syntheses and Antimuscarinic Properties of Optically Active (2-Aminoethyl)cyclohexyl(hydroxymethyl)phenylsilanes and Related Quaternary Ammonium Derivatives by Tacke, Reinhold, Reichel, Dirk, Kropfgans, Martin, Jones, Peter G, Mutschler, Ernst, Gross, Jan, Hou, Xue, Waelbroeck, Magali, Lambrecht, Guenter

Get full text

An alternative presentation of metabolism by Waelbroeck, Magali

“…Why should we think of enzymes as sluice gates? We are used to talk about “metabolic flux”: I should like to suggest that we should indeed envision metabolism…”
Get full text

An alternative presentation of metabolism: Enzyme-catalyzed reactions can be viewed as atoms flowing through sluice gates by Waelbroeck, Magali

“…Why should we think of enzymes as sluice gates? We are used to talk about "metabolic flux": I should like to suggest that we should indeed envision metabolism…”
Get full text

Mutational and Cysteine Scanning Analysis of the Glucagon Receptor N-terminal Domain by Prévost, Martine, Vertongen, Pascale, Raussens, Vincent, Roberts, David Jonathan, Cnudde, Johnny, Perret, Jason, Waelbroeck, Magali

“…The glucagon receptor belongs to the B family of G-protein coupled receptors. Little structural information is available about this receptor and its…”
Get full text

New functionally selective muscarinic agonists by Lambrecht, G, Moser, U, Grimm, U, Pfaff, O, Hermanni, U, Hildebrandt, C, Waelbroeck, M, Christophe, J, Mutschler, E

“…The muscarinic pharmacology of two novel agonists related to McN-A-343, 4-F-PyMcN and 4-F-PyMcN+, has been studied by the use of pharmacological and…”
Get more information

Properties of a recombinant human secretin receptor : A comparison with the rat and rabbit receptors by DI PAOLO, E, DE NEEF, P, MOGUILEVSKY, N, PETRY, H, CNUDDE, J, BOLLEN, A, WAELBROECK, M, ROBBERECHT, P

“…A secretin receptor was cloned from a commercial human pancreatic complementary DNA (cDNA) bank. The amino acid sequence deduced from the nucleotide sequence…”
Get full text

The Long-Acting Vasoactive Intestinal Polypeptide Agonist RO 25-1553 Is Highly Selective of the VIP 2 Receptor Subclass by Gourlet, Philippe, Vertongen, Pascale, Vandermeers, Andre, Vandermeers-piret, Marie-Claire, Rathe, Jean, De Neef, Philippe, Waelbroeck, Magali, Robberecht, Patrick

Get full text