Search Results - "Waeckel, Ludovic"

Autotaxin facilitates selective LPA receptor signaling by Salgado-Polo, Fernando, Borza, Razvan, Matsoukas, Minos-Timotheos, Marsais, Florence, Jagerschmidt, Catherine, Waeckel, Ludovic, Moolenaar, Wouter H, Ford, Paul, Heckmann, Bertrand, Perrakis, Anastassis

“…Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA ) and P2Y (LPA ) G protein-coupled…”
Get more information

Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats by Taveau, Christopher, Chollet, Catherine, Waeckel, Ludovic, Desposito, Dorinne, Bichet, Daniel G., Arthus, Marie-Françoise, Magnan, Christophe, Philippe, Erwann, Paradis, Valerie, Foufelle, Fabienne, Hainault, Isabelle, Enhorning, Sofia, Velho, Gilberto, Roussel, Ronan, Bankir, Lise, Melander, Olle, Bouby, Nadine

“…Aims/hypothesis High plasma copeptin, a marker of vasopressin (VP) secretion, has been shown to be associated with the metabolic syndrome and development of…”
Get full text

Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases by Mammoliti, Oscar, Jansen, Koen, El Bkassiny, Sandy, Palisse, Adeline, Triballeau, Nicolas, Bucher, Denis, Allart, Brigitte, Jaunet, Alex, Tricarico, Giovanni, De Wachter, Maxim, Menet, Christel, Blanc, Javier, Letfus, Vatroslav, Rupčić, Renata, Šmehil, Mario, Poljak, Tanja, Coornaert, Beatrice, Sonck, Kathleen, Duys, Inge, Waeckel, Ludovic, Lecru, Lola, Marsais, Florence, Jagerschmidt, Catherine, Auberval, Marielle, Pujuguet, Philippe, Oste, Line, Borgonovi, Monica, Wakselman, Emanuelle, Christophe, Thierry, Houvenaghel, Nicolas, Jans, Mia, Heckmann, Bertrand, Sanière, Laurent, Brys, Reginald

“…Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease. Current treatments only slow down disease progression, making new therapeutic…”
Get full text

Kinin receptor agonism restores hindlimb postischemic neovascularization capacity in diabetic mice by Desposito, Dorinne, Potier, Louis, Chollet, Catherine, Gobeil, Jr, Fernand, Roussel, Ronan, Alhenc-Gelas, Francois, Bouby, Nadine, Waeckel, Ludovic

“…Limb ischemia is a major complication of thromboembolic diseases. Diabetes worsens prognosis by impairing neovascularization. Genetic or pharmacological…”
Get more information

Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency by Potier, Louis, Waeckel, Ludovic, Richer, Christine, Roussel, Ronan, Bouby, Nadine, Alhenc-Gelas, Francois

“…Tissue kallikrein has been suggested to be involved in blood pressure regulation and in protection against hypertension. However, this hypothesis remains…”
Get more information

Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm by Waeckel, Ludovic, Badier-Commander, Cécile, Damery, Thibaut, Köhler, Ralf, Sansilvestri-Morel, Patricia, Simonet, Serge, Vayssettes-Courchay, Christine, Wulff, Heike, Félétou, Michel

“…Angiotensin-II and oxidative stress are involved in the genesis of aortic aneurysms, a phenomenon exacerbated by endothelial nitric oxide synthase (eNOS)…”
Get full text

Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy by DONG YOU, WAECKEL, Ludovic, TOBELEM, Gérard, LEVY, Bernard I, SILVESTRE, Jean-Sébastien, EBRAHIMIAN, Téni G, BLANC-BRUDE, Olivier, FOUBERT, Philippe, BARATEAU, Véronique, DURIEZ, Micheline, LERICOUSSE-ROUSSANNE, Sophie, VILAR, José, DEJANA, Elisabetta

“…Proangiogenic cell therapy based on administration of bone marrow-derived mononuclear cells (BMCs) or endothelial progenitor cells (EPCs) is now under…”
Get full text

Vascular fate of adipose tissue-derived adult stromal cells in the ischemic murine brain: A combined imaging-histological study by Kubis, Nathalie, Tomita, Yutaka, Tran-Dinh, Alexy, Planat-Benard, Valérie, André, Mireille, Karaszewski, Bartosz, Waeckel, Ludovic, Pénicaud, Luc, Silvestre, Jean-Sébastien, Casteilla, Louis, Seylaz, Jacques, Pinard, Elisabeth

“…Increasing evidence indicates that fat tissue can provide a novel source of progenitor cells with therapeutic potential. Here, the fate of adipose…”
Get full text

Impairment in Postischemic Neovascularization in Mice Lacking the CXC Chemokine Receptor 3 by Waeckel, Ludovic, Mallat, Ziad, Potteaux, Stéphane, Combadière, Christophe, Clergue, Michel, Duriez, Micheline, Bao, Lu, Gerard, Craig, Rollins, Barrett J, Tedgui, Alain, Levy, Bernard I, Silvestre, Jean-Sébastien

“…Inflammatory cell infiltration is a feature of postischemic neovascularization. However, mechanisms leading to leukocyte attraction to the site of…”
Get full text

Tetrapeptide AcSDKP Induces Postischemic Neovascularization Through Monocyte Chemoattractant Protein-1 Signaling by Waeckel, Ludovic, Bignon, Jérôme, Liu, Jian-Miao, Markovits, Delphine, Ebrahimian, Téni G, Vilar, José, Mees, Barend, Blanc-Brude, Olivier, Barateau, Véronique, Le ricousse-Roussanne, Sophie, Duriez, Micheline, Tobelem, Gérard, Wdzieczak-Bakala, Joanna, Lévy, Bernard I, Silvestre, Jean-Sébastien

“…BACKGROUND—We investigated the putative proangiogenic activity and molecular pathway(s) of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) in a model of…”
Get full text

Thromboxane A2/Prostaglandin H2 Receptor Activation Mediates Angiotensin II–Induced Postischemic Neovascularization by Michel, Frédéric, Silvestre, Jean-Sébastien, Waeckel, Ludovic, Corda, Stefano, Verbeuren, Tony, Vilaine, Jean Paul, Clergue, Michel, Duriez, Micheline, Levy, Bernard I

“…OBJECTIVE—We analyzed the involvement of thromboxane (TX) A2/prostaglandin (PG) H2 (TP) receptor in ischemia-induced neovascularization in mice. METHODS AND…”
Get full text

Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism by Nguyen, Van Tuan, Farman, Nicolette, Maubec, Eve, Nassar, Dany, Desposito, Dorinne, Waeckel, Ludovic, Aractingi, Sélim, Jaisser, Frederic

“…Impaired cutaneous wound healing is a social burden. It occurs as a consequence of glucocorticoid treatment in several pathologies. Glucocorticoids (GC) bind…”
Get full text

Selective kinin receptor agonists as cardioprotective agents in myocardial ischemia and diabetes by Potier, Louis, Waeckel, Ludovic, Vincent, Marie-Pascale, Chollet, Catherine, Gobeil, Jr, Fernand, Marre, Michel, Bruneval, Patrick, Richer, Christine, Roussel, Ronan, Alhenc-Gelas, François, Bouby, Nadine

“…Cardiac ischemia is a leading cause of death, especially in diabetic patients. The diabetic ischemic heart is resistant experimentally to established…”
Get more information

Kallikrein(K1)-kinin-kininase (ACE) and end-organ damage in ischemia and diabetes: therapeutic implications by Desposito, Dorinne, Waeckel, Ludovic, Potier, Louis, Richer, Christine, Roussel, Ronan, Bouby, Nadine, Alhenc-Gelas, Francois

“…Genetic and pharmacological studies, clinical and experimental, focused on kallikrein-K1, kinin receptors and ACE/kininase II suggest that kinin release in the…”
Get more information

Improvement of skin wound healing in diabetic mice by kinin B2 receptor blockade by Desposito, Dorinne, Chollet, Catherine, Taveau, Christopher, Descamps, Vincent, Alhenc-Gelas, François, Roussel, Ronan, Bouby, Nadine, Waeckel, Ludovic

“…Impaired skin wound healing is a major medical problem in diabetic subjects. Kinins exert a number of vascular and other actions limiting organ damage in…”
Get more information

Antihypertensive Role of Tissue Kallikrein in Hyperaldosteronism in the Mouse by Waeckel, Ludovic, Potier, Louis, Chollet, Catherine, Taveau, Christopher, Bruneval, Patrick, Roussel, Ronan, Alhenc-Gelas, François, Bouby, Nadine

“…Tissue kallikrein (TK) is synthesized in arteries and distal renal tubule, the main target of aldosterone. Urinary kallikrein excretion increases in…”
Get full text

NADPH Oxidase-Derived Overproduction of Reactive Oxygen Species Impairs Postischemic Neovascularization in Mice with Type 1 Diabetes by Ebrahimian, Téni G, Heymes, Christophe, You, Dong, Blanc-Brude, Olivier, Mees, Barend, Waeckel, Ludovic, Duriez, Micheline, Vilar, José, Brandes, Ralph P., Levy, Bernard I., Shah, Ajay M., Silvestre, Jean-Sébastien

“…We hypothesized that diabetes-induced oxidative stress may affect postischemic neovascularization. The response to unilateral femoral artery ligation was…”
Get full text

Regulatory T Cells Modulate Postischemic Neovascularization by ZOUGGARI, Yasmine, AIT-OUFELLA, Hafid, MALLAT, Ziad, SILVESTRE, Jean-Sébastien, WAECKEL, Ludovic, VILAR, José, LOINARD, Céline, COCHAIN, Clément, RECALDE, Alice, DURIEZ, Micheline, LEVY, Bernard I, LUTGENS, Ester

“…CD4+ and CD8+ T lymphocytes are key regulators of postischemic neovascularization. T-cell activation is promoted by 2 major costimulatory signalings, the…”
Get full text

Abstract 334: Selective Pharmacological Kinin Receptor Activation Restores Postischemic Neovascularisation And Hindlimb Perfusion In Diabetic Mice by Desposito, Dorinne, Potier, Louis, Chollet, Catherine, Gobeil, Fernand, Roussel, Ronan, Bouby, Nadine, Alhenc-Gelas, Francois, Waeckel, Ludovic

“…Abstract only Limb ischemia (LI) is a major complication of several cardiovascular diseases. Hyperglycaemia worsens LI by impairing neovascularisation. Genetic…”
Get full text

Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure by Waeckel, Ludovic, Bertin, Florence, Clavreul, Nicolas, Damery, Thibaut, Köhler, Ralf, Paysant, Jérôme, Sansilvestri-Morel, Patricia, Simonet, Serge, Vayssettes-Courchay, Christine, Wulff, Heike, Verbeuren, Tony J., Félétou, Michel

“…The purpose of this study was to assess, in the murine kidney, the mechanisms underlying the endothelium-dependent control of vascular tone and whether or not,…”
Get full text