Search Results - "Wadsworth, RM"

Inflammation As A Key Event In The Development Of Neointima Following Vascular Balloon Injury by Wainwright, Cl, Miller, Am, Wadsworth, Rm

“…SUMMARY 1. The present review discusses the current evidence to implicate leucocytes as key players in the development of neointima in arteries that have been…”
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Location and function of VPAC , VPAC and NPR-C receptors in VIP-induced vasodilation of porcine basilar arteries

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Extracellular L‐arginine is required for optimal NO synthesis by eNOS and iNOS in the rat mesenteric artery wall by MacKenzie, Andrew, Wadsworth, Roger M

“…The formation of NO from endothelial nitric oxide synthase (eNOS) in rat superior mesenteric artery rings was dependent on extracellular L‐arginine, and was…”
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PDGF-induced signaling in proliferating and differentiated vascular smooth muscle : Effects of altered intracellular Ca2+ regulation by EGAN, Colin G, WAINWRIGHT, Cherry L, WADSWORTH, Roger M, NIXON, Graeme F

“…Platelet-derived growth factor-BB (PDGF)-induced intracellular signaling is involved in phenotypic modulation of vascular smooth muscle (VSM). This study has…”
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In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery by Simonsen, Ulf, Wadsworth, Roger M., Buus, Niels Henrik, Mulvany, Michael J.

“…The relationship between nitric oxide (NO) concentration measured with an NO-specific microelectrode and endothelium-dependent relaxation was investigated in…”
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Induction of iNOS restricts functional activity of both eNOS and nNOS in pig cerebral artery by Mathewson, Alastair M., Wadsworth, Roger M.

“…The aim of the study was to investigate the effect of iNOS expression on eNOS and nNOS functional activity in porcine cerebral arteries. iNOS was induced in…”
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TNFα increases the inflammatory response to vascular balloon injury without accelerating neointimal formation by Miller, Ashley M., McPhaden, Allan R., Preston, Anthony, Wadsworth, Roger M., Wainwright, Cherry L.

“…There is now clear evidence for a contributory role of inflammatory processes to restenosis following vascular balloon injury and stent implantation. The aim…”
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Superoxide in the pulmonary circulation by Demiryürek, A.Tuncay, Wadsworth, Roger M.

“…Superoxide formation in pulmonary tissue is modulated by cytokines, P o 2, shear force, and disease states, and can be stimulated by drugs. Superoxide has…”
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Endothelial, inducible and neuronal nitric oxide synthase in congenital pulmonary lymphangiectasis by Hoehn, T, William, M, McPhaden, A. R, Stannigel, H, Mayatepek, E, Wadsworth, R. M

“…Abnormal growth and development of lymphatic pulmonary structures leads to severe hypoxia in congenital pulmonary lymphangiectasis (CPL). This case study aims…”
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Vasoconstrictor and vasodilator effects of hypoxia by Wadsworth, R M

“…Hypoxia has marked effects on artery calibre, which reflects important physiological control mechanisms that are altered in disease states. Hypoxia modifies…”
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Short-term local delivery of an inhibitor of ras farnesyltransferase prevents neointima formation in vivo after porcine coronary balloon angioplasty by WORK, Lorraine M, MCPHADEN, Allan R, PYNE, Nigel J, PYNE, Susan, WADSWORTH, Roger M, WAINWRIGHT, Cherry L

“…Mitogenic stimuli present at the site of coronary arterial balloon injury contribute to the progression and development of a restenotic lesion, many signaling…”
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Endothelial nitric oxide synthase (NOS) is upregulated in rapid progressive pulmonary hypertension of the newborn by HOEHN, Thomas, PRESTON, Anthony A, MCPHADEN, Allan R, STILLER, Brigitte, VOGEL, Martin, BÜHRER, Christoph, WADSWORTH, Roger M

“…To provide evidence for the upregulation of endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) in the assumed imbalance in the…”
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Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases by Belham, C M, Tate, R J, Scott, P H, Pemberton, A D, Miller, H R, Wadsworth, R M, Gould, G W, Plevin, R

“…We have examined protease-mediated activation of the mitogen-activated protein (MAP) kinase cascade in rat aortic smooth-muscle cells and bovine pulmonary…”
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Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis by Miller, Ashley M., McPhaden, Allan R., Wadsworth, Roger M., Wainwright, Cherry L.

“…Abstract Objective: The aim of the current study was to examine neointima formation in balloon injured left subclavian artery of rabbits subjected to two…”
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The induction and detection in vitro of iNOS in the porcine basilar artery by Mathewson, A.M, McPhaden, A.R, Wadsworth, R.M

“…The expression of iNOS in vascular tissues has an adverse effect on vascular responses to vasoconstrictors and NO-mediated vasodilators. The development of a…”
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Hypoxic stimulation of the stress-activated protein kinases in pulmonary artery fibroblasts by SCOTT, P. H, PAUL, A, BELHAM, C. M, PEACOCK, A. J, WADSWORTH, R. M, GOULD, G. W, WELSH, D, PLEVIN, R

“…Pulmonary hypertension in response to chronic hypoxia is invariably accompanied by remodeling of the pulmonary vessels but the mechanism by which hypoxia…”
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Correlation of leukocyte adhesiveness, adhesion molecule expression and leukocyte‐induced contraction following balloon angioplasty by Kennedy, Simon, McPhaden, Allan R, Wadsworth, Roger M, Wainwright, Cherry L

“…The aim of this study was to examine the changes in leukocyte adhesion and leukocyte‐induced contraction in balloon‐injured rabbit subclavian artery and to…”
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Correlation of changes in nitric oxide synthase, superoxide dismutase and nitrotyrosine with endothelial regeneration and neointimal hyperplasia in the balloon-injured rabbit subclavian artery by Kennedy, Simon, Preston, Anthony A, McPhaden, Allan R, Miller, Ashley M, Wainwright, Cherry L, Wadsworth, Roger M

“…OBJECTIVESAlterations in nitric oxide (NO) and superoxide production within the wall of injured vessels may modulate the development and eventual extent of…”
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Accumulation of Nitrotyrosine Correlates with Endothelial NO Synthase in Pulmonary Resistance Arteries During Chronic Hypoxia in the Rat by Demiryürek, AT, Karamsetty, MR, McPhaden, AR, Wadsworth, RM, Kane, KA, MacLean, MR

“…Nitrotyrosine and eNOS were detected immunocytochemically using specific antibodies in paraffin sections of lung from rats subjected to hypoxia for 2, 7, or 14…”
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A rapid, quantitative method for measuring leukocyte adhesion to normal and balloon-injured arteries in vitro by Kennedy, S, Wadsworth, R.M, McPhaden, A.R, Wainwright, C.L

“…Many of the currently available techniques for quantifying leukocyte adhesion require monolayers of cells and are therefore unsuitable for use in ex vivo…”
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