Search Results - "Wadsworth, G"

The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans by Chisholm, Andrew D, Hutter, Harald, Jin, Yishi, Wadsworth, William G

“…The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal processes during development. In the past two decades, great progress has…”
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SAX-3 (Robo) and UNC-40 (DCC) regulate a directional bias for axon guidance in response to multiple extracellular cues by Tang, Xia, Wadsworth, William G

“…Axons in Caenorhabditis elegans are guided by multiple extracellular cues, including UNC-6 (netrin), EGL-20 (wnt), UNC-52 (perlecan), and SLT-1 (slit). How…”
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Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity by Yang, Yong, Lee, Won Suk, Tang, Xia, Wadsworth, William G

“…How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral…”
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Axon guidance: asymmetric signaling orients polarized outgrowth by Quinn, Christopher C, Wadsworth, William G

“…A network of connections is established as neural circuits form between neurons. To make these connections, neurons initiate asymmetric axon outgrowth in…”
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CED-10/Rac1 Mediates Axon Guidance by Regulating the Asymmetric Distribution of MIG-10/Lamellipodin by Quinn, Christopher C., Pfeil, Douglas S., Wadsworth, William G.

“…Axon migrations are guided by extracellular cues that induce asymmetric outgrowth activity in the growth cone [1, 2]. Several intracellular signaling proteins…”
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Patient Satisfaction with Pharmacist-Provided Health-Related Services in a Primary Care Clinic by Jordan, Jacob N., Wadsworth, Thomas G., Robinson, Renee, Hruza, Hayli, Paul, Amy, O’Connor, Shanna K.

“…(1) Background: Patient satisfaction plays an important role in the perceived value, sustained utilization, and coverage of healthcare services by payers and…”
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Understanding axon guidance： attraction, repulsion, and statistical physics by Wadsworth, William G

“…Understanding axon guidance is important for developing therapies to restore neuronal connections damaged by injury or disease. Axons migrate in response to…”
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Moving around in a worm: netrin UNC-6 and circumferential axon guidance in C. elegans by Wadsworth, William G

“…How does an extracellular guidance molecule direct multiple growth cones to different positions? The answer is important for understanding the development of…”
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Neurodevelopment: UNC-40/DCC and the Patterning of Neural Circuits by Wadsworth, William G

“…A new study in Caenorhabditis elegans suggests the ubiquitin-proteasome system promotes degradation of the netrin receptor UNC-40 in a particular neuron only…”
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Establishment of a Framework to Support Multi-Faceted Initiatives for Pharmacy-Practice Transformation: Lessons Learned by Robinson, Renee, O’Connor, Shanna K., Hruza, Hayli, Nguyen, Elaine, Biddle, Michael A., Jaglowicz, Angela, Wadsworth, Thomas G.

“…We describe the first two years of a multifaceted, five-year program to support sustainable pharmacist-provided health services in Alaska. In 2018, the Alaska…”
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Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans by Wadsworth, William G, Bhatt, Harshida, Hedgecock, Edward M

“…Netrins are laminin-related proteins that guide circumferential migrations on the ectoderm. To understand how netrin cues direct cell movements, we examined…”
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UNC-6/Netrin and SLT-1/Slit Guidance Cues Orient Axon Outgrowth Mediated by MIG-10/RIAM/Lamellipodin by Quinn, Christopher C., Pfeil, Douglas S., Chen, Esteban, Stovall, Elizabeth L., Harden, Maegan V., Gavin, Megan K., Forrester, Wayne C., Ryder, Elizabeth F., Soto, Martha C., Wadsworth, William G.

“…Axon migrations are guided by extracellular cues that can act as repellants or attractants. However, the logic underlying the manner through which attractive…”
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A perspective on SOAL, a stochastic model of neuronal outgrowth by Wadsworth, William G.

“…A functional nervous system requires neuronal connections to be made in a highly detailed and stereotypic manner. During development, neurons extend processes…”
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Assembly and tissue functions of early embryonic laminins and netrins by Yurchenco, Peter D, Wadsworth, William G

“…Vertebrate laminins and netrins share N-terminal domain structure, but appear to be only distantly related. Both families can be divided into different…”
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Laminin alpha subunits and their role in C. elegans development by Huang, Cheng-Chen, Hall, David H, Hedgecock, Edward M, Kao, Gautam, Karantza, Vassiliki, Vogel, Bruce E, Hutter, Harald, Chisholm, Andrew D, Yurchenco, Peter D, Wadsworth, William G

“…Laminins are heterotrimeric (alpha/beta/gamma) glycoproteins that form a major polymer within basement membranes. Different alpha, beta and gamma subunits can…”
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Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity by Kulkarni, Gauri, Xu, Zhennan, Mohamed, Ahmed M, Li, Haichang, Tang, Xia, Limerick, Gerard, Wadsworth, William G

“…How the direction of axon guidance is determined is not understood. In Caenorhabditis elegans the UNC-40 (DCC) receptor mediates a response to the UNC-6…”
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Positioning of Longitudinal Nerves in C. elegans by Nidogen by Kim, Seonhee, Wadsworth, William G.

“…Basement membranes can help determine pathways of migrating axons. Although members of the nidogen (entactin) protein family are structural components of…”
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Axon response to guidance cues is stimulated by acetylcholine in Caenorhabditis elegans by Xu, Yan, Ren, Xing-Cong, Quinn, Christopher C, Wadsworth, William G

“…Gradients of acetylcholine can stimulate growth cone turning when applied to neurons grown in culture, and it has been suggested that acetylcholine could act…”
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Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety by Weiss, S.M, Wadsworth, G, Fletcher, A, Dourish, C.T

“…The elevated plus-maze is a commonly used model to identify putative anxiolytic and anxiogenic drugs. However, the validity of elevated plus-maze and other…”
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Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes by PARSONS, G. B, SOUZA, D. W, WU, H, YU, D, WADSWORTH, S. G, GREGORY, R. J, ARMENTANO, D

“…Glucagon-like peptide 1 (GLP-1) is a promising candidate for the treatment of type II diabetes. However, the short in vivo half-life of GLP-1 has made…”
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