Refractory coeliac disease a reality: views from Pakistan

Refractory coeliac disease a reality: views from Pakistan

Refractory coeliac disease (RCD) is described as persistence or recurrence of signs and symptoms of malabsorption with small-intestinal villous atrophy despite being on a strict gluten-free diet (GFD) for more than 12 months. RCD is a diagnosis of exclusion. There are two types of RCD, based upon th...

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Bibliographic Details
Published in:Tropical doctor Vol. 47; no. 1; p. 51
Main Authors: Mandhwani, Rajesh M, Wadhwa, Rajesh K, Laeeq, Syed Mudassir, Luck, Nasir Hasan, Mubarak, Mohammad, Majid, Zain
Format: Journal Article
Language:English
Published: England 01-01-2017
Subjects:
Addison Disease - etiology
Celiac Disease - complications
Celiac Disease - diet therapy
Celiac Disease - drug therapy
Diarrhea - etiology
Diet, Gluten-Free
Duodenum - pathology
Fatal Outcome
Humans
Immunosuppressive Agents - therapeutic use
Male
Pakistan
Young Adult
malabsorption
Pakistan
gluten-free diet
Refractory coeliac disease
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Description
Summary:Refractory coeliac disease (RCD) is described as persistence or recurrence of signs and symptoms of malabsorption with small-intestinal villous atrophy despite being on a strict gluten-free diet (GFD) for more than 12 months. RCD is a diagnosis of exclusion. There are two types of RCD, based upon the immunohistochemical features (presence of intraepithelial lymphocytes), response to treatment and prognosis. The treatment of RCD includes GFD and immunosuppressive agents. We hereby present a case of refractory celiac disease type II in a young man who later went on to develop Addisonian crisis and did not survive.
ISSN:1758-1133
DOI:10.1177/0049475516631710