Search Results - "Waddington, Kirsty E."

Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? by Pineda-Torra, Inés, Siddique, Sherrice, Waddington, Kirsty E, Farrell, Rachel, Jury, Elizabeth C

“…Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination…”
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Liver X receptors in immune cell function in humans by Waddington, Kirsty E, Jury, Elizabeth C, Pineda-Torra, Inés

“…The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol…”
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Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function by Robinson, George A, Waddington, Kirsty E, Pineda-Torra, Ines, Jury, Elizabeth C

“…It is well established that cholesterol and glycosphingolipids are enriched in the plasma membrane (PM) and form signaling platforms called lipid rafts,…”
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Using Serum Metabolomics to Predict Development of Anti-drug Antibodies in Multiple Sclerosis Patients Treated With IFNβ by Waddington, Kirsty E, Papadaki, Artemis, Coelewij, Leda, Adriani, Marsilio, Nytrova, Petra, Kubala Havrdova, Eva, Fogdell-Hahn, Anna, Farrell, Rachel, Dönnes, Pierre, Pineda-Torra, Inés, Jury, Elizabeth C

“…Neutralizing anti-drug antibodies (ADA) can greatly reduce the efficacy of biopharmaceuticals used to treat patients with multiple sclerosis (MS). However, the…”
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Manipulating membrane lipid profiles to restore T-cell function in autoimmunity by Waddington, Kirsty E, Jury, Elizabeth C

“…Plasma membrane lipid rafts are heterogeneous cholesterol and glycosphingolipid (GSL)-enriched microdomains, within which the tight packing of cholesterol with…”
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Blood metabolomic and transcriptomic signatures stratify patient subgroups in multiple sclerosis according to disease severity by Oppong, Alexandra E., Coelewij, Leda, Robertson, Georgia, Martin-Gutierrez, Lucia, Waddington, Kirsty E., Dönnes, Pierre, Nytrova, Petra, Farrell, Rachel, Pineda-Torra, Inés, Jury, Elizabeth C.

“…There are no blood-based biomarkers distinguishing patients with relapsing-remitting (RRMS) from secondary progressive multiple sclerosis (SPMS) although…”
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Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach by Bassi, Zuni I, Fillmore, Martin C, Miah, Afjal H, Chapman, Trevor D, Maller, Claire, Roberts, Emma J, Davis, Lauren C, Lewis, Darcy E, Galwey, Nicholas W, Waddington, Kirsty E, Parravicini, Valentino, Macmillan-Jones, Abigail L, Gongora, Celine, Humphreys, Philip G, Churcher, Ian, Prinjha, Rab K, Tough, David F

“…P300/CBP-associated factor (PCAF) and general control nonderepressible 5 (GCN5) are closely related epigenetic proteins, each containing an acetyltransferase…”
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Dysregulated lipid metabolism networks modulate T-cell function in people with relapsing-remitting multiple sclerosis by Martin-Gutierrez, Lucia, Waddington, Kirsty E, Maggio, Annalisa, Coelewij, Leda, Oppong, Alexandra E, Yang, Nina, Adriani, Marsilio, Nytrova, Petra, Farrell, Rachel, Pineda-Torra, Inés, Jury, Elizabeth C

“…Altered cholesterol, oxysterol, sphingolipid, and fatty acid concentrations are reported in blood, cerebrospinal fluid, and brain tissue of people with…”
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Patients with multiple sclerosis who develop immunogenicity to interferon-beta have distinct transcriptomic and proteomic signatures prior to treatment which are associated with disease severity by Coelewij, Leda, Adriani, Marsilio, Dönnes, Pierre, Waddington, Kirsty E., Ciurtin, Coziana, Havrdova, Eva Kubala, Farrell, Rachel, Nytrova, Petra, Pineda-Torra, Inés, Jury, Elizabeth C.

“…Anti-drug antibodies (ADA) reduce the efficacy of immunotherapies in multiple sclerosis (MS) and are associated with increased disease progression risk. Blood…”
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Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus by Coelewij, Leda, Waddington, Kirsty E., Robinson, George A., Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Dönnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C., Pineda-Torra, Ines

“…[Figure: see text]…”
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LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function by Waddington, Kirsty E., Robinson, George A., Rubio-Cuesta, Beatriz, Chrifi-Alaoui, Eden, Andreone, Sara, Poon, Kok-Siong, Ivanova, Iveta, Martin-Gutierrez, Lucia, Owen, Dylan M., Jury, Elizabeth C., Pineda-Torra, Inés

“…The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic…”
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Stratification of Patients With Sjögren’s Syndrome and Patients With Systemic Lupus Erythematosus According to Two Shared Immune Cell Signatures, With Potential Therapeutic Implications by Martin‐Gutierrez, Lucia, Peng, Junjie, Thompson, Nicolyn L., Robinson, George A., Naja, Meena, Peckham, Hannah, Wu, WingHan, J’bari, Hajar, Ahwireng, Nyarko, Waddington, Kirsty E., Bradford, Claire M., Varnier, Giulia, Gandhi, Akash, Radmore, Rebecca, Gupta, Vivek, Isenberg, David A., Jury, Elizabeth C., Ciurtin, Coziana

“…Objective Similarities in the clinical and laboratory features of primary Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE) have led to attempts…”
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Analyzing T-Cell Plasma Membrane Lipids by Flow Cytometry by Waddington, Kirsty E, Pineda-Torra, Inés, Jury, Elizabeth C

“…Plasma membrane lipid rafts are highly ordered membrane microdomains enriched for glycosphingolipids and cholesterol, which play an important role during…”
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Increased apolipoprotein-B:A1 ratio predicts cardiometabolic risk in patients with juvenile onset SLE by Robinson, George A., Waddington, Kirsty E., Coelewij, Leda, Peng, Junjie, Naja, Meena, Wincup, Chris, Radziszewska, Anna, Peckham, Hannah, Isenberg, David A., Ioannou, Yiannis, Ciurtin, Coziana, Pineda-Torra, Ines, Jury, Elizabeth C.

“…Cardiovascular disease is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE). Traditional factors for…”
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The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms by Pourcet, Benoit, Gage, Matthew C., León, Theresa E., Waddington, Kirsty E., Pello, Oscar M., Steffensen, Knut R., Castrillo, Antonio, Valledor, Annabel F., Pineda-Torra, Inés

“…IL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple…”
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Serum metabolomic signatures can predict sub-clinical atherosclerosis in patients with SLE by Coelewij, Leda, Waddington, Kirsty E, Robinson, George A, Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Dönnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C, Pineda-Torra, Ines

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Serum Metabolomic Signatures Can Predict Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus by Coelewij, Leda, Waddington, Kirsty E., Robinson, George A., Chocano, Elvira, McDonnell, Thomas, Farinha, Filipa, Peng, Junjie, Donnes, Pierre, Smith, Edward, Croca, Sara, Bakshi, Jyoti, Griffin, Maura, Nicolaides, Andrew, Rahman, Anisur, Jury, Elizabeth C., Pineda-Torra, Ines

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Two shared immune cell signatures stratify patients with Sjögren's syndrome and systemic lupus erythematosus with potential therapeutic implications by Martin-Gutierrez, Lucia, Peng, Junjie, Thompson, Nicolyn L, Robinson, George A, Naja, Meena, Peckham, Hannah, Wu, WingHan, J'bari, Hajar, Ahwireng, Nyarko, Waddington, Kirsty E, Bradford, Claire M, Varnier, Giulia, Gandhi, Akash, Radmore, Rebecca, Gupta, Vivek, Isenberg, David A, Jury, Elizabeth C, Ciurtin, Coziana

“…Similarities in the clinical and laboratory features of patients with primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE) have led to…”
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