Search Results - "Waddington, Claire S."

Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A randomised, double-blind, noninferiority trial by Pérez Chacón, Gladymar, Estcourt, Marie J, Totterdell, James, Marsh, Julie A, Perrett, Kirsten P, Campbell, Dianne E, Wood, Nicholas, Gold, Michael, Waddington, Claire S, O' Sullivan, Michael, McAlister, Sonia, Curtis, Nigel, Jones, Mark, McIntyre, Peter B, Holt, Patrick G, Richmond, Peter C, Snelling, Tom

“…In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on…”
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Changes in monocyte subsets in volunteers who received an oral wild-type Salmonella Typhi challenge and reached typhoid diagnosis criteria by Toapanta, Franklin R, Hu, Jingping, Shirey, Kari Ann, Bernal, Paula J, Levine, Myron M, Darton, Thomas C, Waddington, Claire S, Pollard, Andrew J, Sztein, Marcelo B

“…An oral Controlled Human Infection Model (CHIM) with wild-type . Typhi was re-established allowing us to explore the development of immunity. In this model,…”
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Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S . Typhi in humans by Booth, Jayaum S, Rapaka, Rekha R, McArthur, Monica A, Fresnay, Stephanie, Darton, Thomas C, Blohmke, Christoph J, Jones, Claire, Waddington, Claire S, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…Despite decades of intense research, our understanding of the correlates of protection against Typhi ( . Typhi) infection and disease remains incomplete. T…”
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Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans by Darton, Thomas C, Blohmke, Christoph J, Giannoulatou, Eleni, Waddington, Claire S, Jones, Claire, Sturges, Pamela, Webster, Craig, Drakesmith, Hal, Pollard, Andrew J, Armitage, Andrew E

“…Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely…”
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Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a by Darton, Thomas C, Jones, Claire, Blohmke, Christoph J, Waddington, Claire S, Zhou, Liqing, Peters, Anna, Haworth, Kathryn, Sie, Rebecca, Green, Christopher A, Jeppesen, Catherine A, Moore, Maria, Thompson, Ben A V, John, Tessa, Kingsley, Robert A, Yu, Ly-Mee, Voysey, Merryn, Hindle, Zoe, Lockhart, Stephen, Sztein, Marcelo B, Dougan, Gordon, Angus, Brian, Levine, Myron M, Pollard, Andrew J

“…Typhoid persists as a major cause of global morbidity. While several licensed vaccines to prevent typhoid are available, they are of only moderate efficacy and…”
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Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model by McArthur, Monica A, Fresnay, Stephanie, Magder, Laurence S, Darton, Thomas C, Jones, Claire, Waddington, Claire S, Blohmke, Christoph J, Dougan, Gordon, Angus, Brian, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…Salmonella Typhi (S. Typhi), the causative agent of typhoid fever, causes significant morbidity and mortality worldwide. Currently available vaccines are…”
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Working towards a Group A Streptococcal vaccine: Report of a collaborative Trans-Tasman workshop by Moreland, Nicole J, Waddington, Claire S, Williamson, Deborah A, Sriskandan, Shiranee, Smeesters, Pierre R, Proft, Thomas, Steer, Andrew C, Walker, Mark J, Baker, Edward N, Baker, Michael G, Lennon, Diana, Dunbar, Rod, Carapetis, Jonathan, Fraser, John D

“…Abstract Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand…”
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Development and validation of a dynamic 48-hour in-hospital mortality risk stratification for COVID-19 in a UK teaching hospital: a retrospective cohort study by Wiegand, Martin, Cowan, Sarah L, Waddington, Claire S, Halsall, David J, Keevil, Victoria L, Tom, Brian D M, Taylor, Vince, Gkrania-Klotsas, Effrossyni, Preller, Jacobus, Goudie, Robert J B

“…ObjectivesTo develop a disease stratification model for COVID-19 that updates according to changes in a patient’s condition while in hospital to facilitate…”
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OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule by Perez Chacon, Gladymar, Estcourt, Marie J, Totterdell, James, Campbell, Dianne E, Perrett, Kirsten P, Marsh, Julie A, Richmond, Peter C, Wood, Nicholas, Gold, Michael S, Holt, Patrick G, Waddington, Claire S, Snelling, Thomas L

“…IntroductionCombination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and…”
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Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease by Toapanta, Franklin R, Bernal, Paula J, Fresnay, Stephanie, Darton, Thomas C, Jones, Claire, Waddington, Claire S, Blohmke, Christoph J, Dougan, Gordon, Angus, Brian, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted…”
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Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease by Toapanta, Franklin R, Bernal, Paula J, Fresnay, Stephanie, Magder, Laurence S, Darton, Thomas C, Jones, Claire, Waddington, Claire S, Blohmke, Christoph J, Angus, Brian, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…A novel human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently established by the Oxford Vaccine Group. In this model, 104 CFU of…”
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Assessment and Translation of the Antibody-in-Lymphocyte Supernatant (ALS) Assay to Improve the Diagnosis of Enteric Fever in Two Controlled Human Infection Models and an Endemic Area of Nepal by Darton, Thomas C, Jones, Claire, Dongol, Sabina, Voysey, Merryn, Blohmke, Christoph J, Shrestha, Rajendra, Karkey, Abhilasha, Shakya, Mila, Arjyal, Amit, Waddington, Claire S, Gibani, Malick, Carter, Michael J, Basnyat, Buddha, Baker, Stephen, Pollard, Andrew J

“…New diagnostic tests for enteric fever are urgently needed to assist with timely antimicrobial treatment of patients and to measure the efficacy of prevention…”
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Identification of the determinants of incomplete vaccination in Australian children by Lim, Christopher, Currie, Grace E, Waddington, Claire S, Wu, Yue, Setijo, Sharon, Leask, Julie, Marsh, Julie A, Snelling, Thomas L

“…We aimed to understand the risk factors associated with incomplete vaccination, which may help to identify and prioritise opportunities to intervene…”
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Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella by Rapaka, Rekha R, Wahid, Rezwanul, Fresnay, Stephanie, Booth, Jayaum S, Darton, Thomas C, Jones, Claire, Waddington, Claire S, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…Objective There are no vaccines for most of the major invasive Salmonella strains causing severe infection in humans. We evaluated the specificity of adaptive…”
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Use of cidofovir in a patient with severe mpox and uncontrolled HIV infection by Stafford, Adam, Rimmer, Stephanie, Gilchrist, Mark, Sun, Kristi, Davies, Ella P, Waddington, Claire S, Chiu, Christopher, Armstrong-James, Darius, Swaine, Thomas, Davies, Frances, Gómez, Carlos H M, Kumar, Vagish, ElHaddad, Ahmad, Awad, Zaid, Smart, Christopher, Mora-Peris, Borja, Muir, David, Randell, Paul, Peters, Joanna, Chand, Meera, Warrell, Clare E, Rampling, Tommy, Cooke, Graham, Dhanji, Sara, Campbell, Vivienne, Davies, Carys, Osman, Sana, Abbara, Aula

“…A 48-year-old man with poorly controlled HIV presented with severe human monkeypox virus (hMPXV) infection, having completed 2 weeks of tecovirimat at another…”
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Immunogenicity of a Third Scheduled Dose of Rotarix in Australian Indigenous Infants: A Phase IV, Double-blind, Randomized, Placebo-Controlled Clinical Trial by Middleton, Bianca F, Danchin, Margie, Jones, Mark A, Leach, Amanda J, Cunliffe, Nigel, Kirkwood, Carl D, Carapetis, Jonathan, Gallagher, Sarah, Kirkham, Lea-Ann, Granland, Caitlyn, McNeal, Monica, Marsh, Julie A, Waddington, Claire S, Snelling, Thomas L

“…Rotarix (GlaxoSmithKline) oral rotavirus vaccine is licensed as 2 doses in the first 6 months of life. In settings with high child mortality rates, clinical…”
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An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution by Waddington, Claire S., Darton, Thomas C., Jones, Claire, Haworth, Kathryn, Peters, Anna, John, Tessa, Thompson, Ben A. V., Kerridge, Simon A., Kingsley, Robert A., Zhou, Liqing, Holt, Kathryn E., Yu, Ly-Mee, Lockhart, Stephen, Farrar, Jeremy J., Sztein, Marcelo B., Dougan, Gordon, Angus, Brian, Levine, Myron M., Pollard, Andrew J.

“…Background. Typhoid fever is a major global health problem, the control of which is hindered by lack of a suitable animal model in which to study Salmonella…”
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Management of invasive group A streptococcal infections by Waddington, Claire S, Snelling, Thomas L, Carapetis, Jonathan R

“…Summary Invasive group A streptococcal (GAS) disease in children includes deep soft tissue infection, bacteraemia, bacteraemic pneumonia, meningitis and…”
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Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model by Dobinson, Hazel C., Gibani, Malick M., Jones, Claire, Thomaides-Brears, Helena B., Voysey, Merryn, Darton, Thomas C., Waddington, Claire S., Campbell, Danielle, Milligan, Iain, Zhou, Liqing, Shrestha, Sonu, Kerridge, Simon A., Peters, Anna, Stevens, Zoe, Podda, Audino, Martin, Laura B., D'Alessio, Flavia, Thanh, Duy Pham, Basnyat, Buddha, Baker, Stephen, Angus, Brian, Levine, Myron M., Blohmke, Christoph J., Pollard, Andrew J.

“…Background. To expedite the evaluation of vaccines against paratyphoid fever, we aimed to develop the first human challenge model of Salmonella enterica…”
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Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever by Salerno-Gonçalves, Rosângela, Fresnay, Stephanie, Magder, Laurence, Darton, Thomas C., Waddington, Claire S., Blohmke, Christoph J., Angus, Brian, Levine, Myron M., Pollard, Andrew J., Sztein, Marcelo B.

“…•First demonstration of cytokine-secreting MAIT cell kinetics after human challenge with Salmonella enterica serovar Typhi.•MAIT cell's functional signatures…”
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