Search Results - "Waddell, T K."

Normothermic Ex Vivo Perfusion Prevents Lung Injury Compared to Extended Cold Preservation for Transplantation by Cypel, M., Rubacha, M., Yeung, J., Hirayama, S., Torbicki, K., Madonik, M., Fischer, S., Hwang, D., Pierre, A., Waddell, T. K., De Perrot, M., Liu, M., Keshavjee, S.

“…Treatment of injured donor lungs ex vivo to accelerate organ recovery and ameliorate reperfusion injury could have a major impact in lung transplantation. We…”
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Distinct Expression Patterns of Alveolar “Alarmins” in Subtypes of Chronic Lung Allograft Dysfunction by Saito, T., Liu, M., Binnie, M., Sato, M., Hwang, D., Azad, S., Machuca, T. N., Zamel, R., Waddell, T. K., Cypel, M., Keshavjee, S.

“…The long‐term success of lung transplantation is limited by chronic lung allograft dysfunction (CLAD). The purpose of this study was to investigate the…”
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Impact of Cytokine Expression in the Pre‐Implanted Donor Lung on the Development of Chronic Lung Allograft Dysfunction Subtypes by Saito, T., Takahashi, H., Kaneda, H., Binnie, M., Azad, S., Sato, M., Waddell, T. K., Cypel, M., Liu, M., Keshavjee, S.

“…The long‐term success of lung transplantation continues to be challenged by the development of chronic lung allograft dysfunction (CLAD). The purpose of this…”
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Pilot Study Exploring Lung Allograft Surfactant Protein A (SP‐A) Expression in Association With Lung Transplant Outcome by D'Ovidio, F., Kaneda, H., Chaparro, C., Mura, M., Lederer, D., Di Angelo, S., Takahashi, H., Gutierrez, C., Hutcheon, M., Singer, L. G., Waddell, T. K., Floros, J., Liu, M., Keshavjee, S.

“…Primary graft failure and chronic lung allograft dysfunction (CLAD) limit lung transplant long–term outcomes. Various lung diseases have been correlated with…”
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Transbronchial administration of adenoviral-mediated interleukin-10 gene to the donor improves function in a pig lung transplant model by MARTINS, S, DE PERROT, M, WADDELL, T. K, LIU, M, KESHAVJEE, S, IMAI, Y, YAMANE, M, QUADRI, S. M, SEGALL, L, DUTLY, A, SAKIYAMA, S, CHAPARRO, A, DAVIDSON, B. L

“…Interleukin-10 (IL-10) gene transfection of donor lungs prior to transplantation is an attractive strategy to reduce ischemia-reperfusion induced lung injury…”
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Impact of Lung Transplant Operation on Bronchiolitis Obliterans Syndrome in Patients with Chronic Obstructive Pulmonary Disease by Hadjiliadis, D., Chaparro, C, Gutierrez, C, Steele, M P., Singer, L G., Davis, R D., Waddell, T K., Hutcheon, M A., Palmer, S M., Keshavjee, S

“…Previous studies suggest that bilateral (BLT) compared with single lung transplantation (SLT) for patients with chronic obstructive pulmonary disease (COPD)…”
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Pre‐Implantation Multiple Cytokine mRNA Expression Analysis of Donor Lung Grafts Predicts Survival After Lung Transplantation in Humans by Kaneda, H., Waddell, T. K., De Perrot, M., Bai, X.‐H., Gutierrez, C., Arenovich, T., Chaparro, C., Liu, M., Keshavjee, S.

“…While current donor selection with clinical findings is generally effective, the imprecise nature of the assessment forces clinicians to remain on the…”
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MMP‐Dependent Migration of Extrapulmonary Myofibroblast Progenitors Contributing to Posttransplant Airway Fibrosis in the Lung by Sato, M., Hirayama, S., Lara‐Guerra, H., Anraku, M., Waddell, T. K., Liu, M., Keshavjee, S.

“…Myofibroblasts play a central role in fibroproliferative airway remodeling in obliterative bronchiolitis (OB) after lung transplantation. The purpose of the…”
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Impact of Human Donor Lung Gene Expression Profiles on Survival after Lung Transplantation: A Case‐Control Study by Anraku, M., Cameron, M. J., Waddell, T. K., Liu, M., Arenovich, T., Sato, M., Cypel, M., Pierre, A. F., De Perrot, M., Kelvin, D. J., Keshavjee, S.

“…Primary graft dysfunction (PGD) continues to be a major cause of early death after lung transplantation. Moreover, there remains a lack of accurate…”
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mTOR Inhibition Induces Endothelial Progenitor Cell Death by Miriuka, S. G., Rao, V., Peterson, M., Tumiati, L., Delgado, D. H., Mohan, R., Ramzy, D., Stewart, D., Ross, H. J., Waddell, T. K.

“…Immunosuppressants are necessary to prevent graft rejection after solid organ transplantation. However, they are also known to have significant side effects,…”
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Allograft Airway Fibrosis in the Pulmonary Milieu: A Disorder of Tissue Remodeling by Sato, M., Liu, M., Anraku, M., Ogura, T., D'Cruz, G., Alman, B. A., Waddell, T. K., Kim, E., Zhang, L., Keshavjee, S.

“…Obliterative bronchiolitis (OB) is thought to be a form of chronic allograft rejection. However, immunosuppressive therapy is not effective once fibrosis has…”
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Gender differences in pulmonary regenerative response to naphthalene-induced bronchiolar epithelial cell injury by Oliver, J. R. , Kushwah, R. , Wu, J. , Cutz, E. , Yeger, H. , Waddell, T. K. , Hu, J. 

“…Objectives:  Accumulating evidence suggests that gender affects the incidence and severity of several pulmonary diseases. Previous studies on mice have shown…”
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Influence of lung volume reduction surgery (LVRS) on health related quality of life in patients with chronic obstructive pulmonary disease by Goldstein, R S, Todd, T R J, Guyatt, G, Keshavjee, S, Dolmage, T E, van Rooy, S, Krip, B, Maltais, F, LeBlanc, P, Pakhale, S, Waddell, T K

“…Background: The clinical value of LVRS has been questioned in the absence of trials comparing it with pulmonary rehabilitation, the prevailing standard of care…”
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Survival in Sensitized Lung Transplant Recipients With Perioperative Desensitization by Tinckam, K. J., Keshavjee, S., Chaparro, C., Barth, D., Azad, S., Binnie, M., Chow, C. W., de Perrot, M., Pierre, A. F., Waddell, T. K., Yasufuku, K., Cypel, M., Singer, L. G.

“…Donor‐specific HLA antibodies (DSA) have an adverse effect on short‐term and long‐term lung transplant outcomes. We implemented a perioperative strategy to…”
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Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs by Nakajima, D., Cypel, M., Bonato, R., Machuca, T. N., Iskender, I., Hashimoto, K., Linacre, V., Chen, M., Coutinho, R., Azad, S., Martinu, T., Waddell, T. K., Hwang, D. M., Husain, S., Liu, M., Keshavjee, S.

“…Ex vivo lung perfusion (EVLP) is a platform to treat infected donor lungs with antibiotic therapy before lung transplantation. Human donor lungs that were…”
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Lung Transplantation With Donation After Circulatory Determination of Death Donors and the Impact of Ex Vivo Lung Perfusion by Machuca, T. N., Mercier, O., Collaud, S., Tikkanen, J., Krueger, T., Yeung, J. C., Chen, M., Azad, S., Singer, L., Yasufuku, K., de Perrot, M., Pierre, A., Waddell, T. K., Keshavjee, S., Cypel, M.

“…The growing demand for suitable lungs for transplantation drives the quest for alternative strategies to expand the donor pool. The aim of this study is to…”
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Successful Lung Transplantation From Hepatitis C Positive Donor to Seronegative Recipient by Khan, B., Singer, L. G., Lilly, L. B., Chaparro, C., Martinu, T., Juvet, S., Pipkin, M., Waddell, T. K., Keshavjee, S., Humar, A., Cypel, M.

“…Lung transplantation using RNA+ hepatitis C (HCV+) donors to seronegative recipients is not currently performed due to the very high risk of transmission…”
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Muscular Strength Training Is Associated With Low Arterial Compliance and High Pulse Pressure by Bertovic, David A, Waddell, Tamara K, Gatzka, Christoph D, Cameron, James D, Dart, Anthony M, Kingwell, Bronwyn A

“…Aerobic exercise training increases arterial compliance and reduces systolic blood pressure, but the effects of muscular strength training on arterial…”
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Soluble Adhesion Molecules During Ex Vivo Lung Perfusion Are Associated With Posttransplant Primary Graft Dysfunction by Hashimoto, K., Cypel, M., Kim, H., Machuca, T. N., Nakajima, D., Chen, M., Hsin, M. K., Zamel, R., Azad, S., Waddell, T. K., Liu, M., Keshavjee, S.

“…Ex vivo lung perfusion (EVLP) enables assessment of marginal donor lungs for transplantation. We aimed to discover biomarkers in EVLP perfusate that could…”
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Management of lung transplant recipients with bronchogenic carcinoma in the native lung by de Perrot, M, Fischer, S, Waddell, T K, Strueber, M, Harringer, W, Pierre, A F, Spiliopoulos, A, Haverich, A, Keshavjee, S

“…Experience with lung transplantation for bronchogenic carcinoma is limited. In our experience, 3 of 6 patients died of recurrent carcinoma within 5 to 35…”
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