Search Results - "Waddell, Helen M"

A novel small molecule inhibitor of human Drp1 by Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.

“…Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous…”
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The function and regulation of calsequestrin-2: implications in calcium-mediated arrhythmias by Sibbles, Elliot T., Waddell, Helen M. M., Mereacre, Valeria, Jones, Peter P., Munro, Michelle L.

“…Cardiac arrhythmias are life-threatening events in which the heart develops an irregular rhythm. Mishandling of Ca 2+ within the myocytes of the heart has been…”
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Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release by Waddell, Helen M.M., Zhang, Joe Z., Hoeksema, Katie J., McLachlan, Julia J., McLay, Janet C., Jones, Peter P.

“…At the single-channel level, oxidation of the cardiac ryanodine receptor (RyR2) is known to activate and inhibit the channel depending on the level of…”
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Identifying sex differences in predictors of epicardial fat cell morphology by Waddell, Helen M. M., Moore, Matthew K., Herbert-Olsen, Morgan A., Stiles, Martin K., Tse, Rexson D., Coffey, Sean, Lamberts, Regis R., Aitken-Buck, Hamish M.

“…Predictors of overall epicardial adipose tissue deposition have been found to vary between males and females. Whether similar sex differences exist in…”
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Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality by Nalliah, Chrishan J, Bell, James R, Raaijmakers, Antonia J A, Waddell, Helen M, Wells, Simon P, Bernasochi, Gabriel B, Montgomery, Magdalene K, Binny, Simon, Watts, Troy, Joshi, Subodh B, Lui, Elaine, Sim, Choon Boon, Larobina, Marco, O'Keefe, Michael, Goldblatt, John, Royse, Alistair, Lee, Geoffrey, Porrello, Enzo R, Watt, Matthew J, Kistler, Peter M, Sanders, Prashanthan, Delbridge, Lea M D, Kalman, Jonathan M

“…Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of atrial fibrillation (AF) pathology and…”
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Clustering properties of the cardiac ryanodine receptor in health and heart failure by Waddell, Helen M.M., Mereacre, Valeria, Alvarado, Francisco J., Munro, Michelle L.

“…The cardiac ryanodine receptor (RyR2) is an intracellular Ca2+ release channel vital for the function of the heart. Physiologically, RyR2 is triggered to…”
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Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems by Wells, Simon P, Waddell, Helen M, Sim, Choon Boon, Lim, Shiang Y, Bernasochi, Gabriel B, Pavlovic, Davor, Kirchhof, Paulus, Porrello, Enzo R, Delbridge, Lea M D, Bell, James R

“…Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic therapies are required to…”
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FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2 by Zhang, Joe Z, Waddell, Helen M M, Wu, Ella, Dholakia, Jhanvi, Okolo, Chidinma A, McLay, Janet C, Jones, Peter P

“…FK506-binding proteins 12.6 (FKBP12.6) and 12 (FKBP12) tightly associate with the cardiac ryanodine receptor (RyR2). Studies suggest that dissociation of…”
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Regulation of RYR2 by sarcoplasmic reticulum Ca2 by Zhang, Joe Z, Waddell, Helen MM, Jones, Peter P

“…Summary Ca2+ is arguably the most important ion involved in the contraction of the heart. The cardiac ryanodine receptor (RyR2), the major Ca2+ release channel…”
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Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality by Nalliah, Chrishan J., Bell, James R., Raaijmakers, Antonia J.A., Waddell, Helen M., Wells, Simon P., Bernasochi, Gabriel B., Montgomery, Magdalene K., Binny, Simon, Watts, Troy, Joshi, Subodh B., Lui, Elaine, Sim, Choon Boon, Larobina, Marco, O’Keefe, Michael, Goldblatt, John, Royse, Alistair, Lee, Geoffrey, Porrello, Enzo R., Watt, Matthew J., Kistler, Peter M., Sanders, Prashanthan, Delbridge, Lea M.D., Kalman, Jonathan M.

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Regulation of RYR2 by sarcoplasmic reticulum Ca(2+) by Zhang, Joe Z, Waddell, Helen M M, Jones, Peter P

“…Ca(2+) is arguably the most important ion involved in the contraction of the heart. The cardiac ryanodine receptor (RyR2), the major Ca(2+) release channel…”
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Regulation of RYR2 by sarcoplasmic reticulum Ca 2 by Zhang, Joe Z, Waddell, Helen MM, Jones, Peter P

“…Summary Ca 2+ is arguably the most important ion involved in the contraction of the heart. The cardiac ryanodine receptor (RyR2), the major Ca 2+ release…”
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