Search Results - "Wada, D Russell"

Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin®), a HER2-targeted monoclonal antibody, in patients with a variety of solid tumors by Quartino, Angelica L., Li, Hanbin, Kirschbrown, Whitney P., Mangat, Ranvir, Wada, D. Russell, Garg, Amit, Jin, Jin Y., Lum, Bert

“…Purpose The aim of the study was to characterize the population pharmacokinetics (PK) of the intravenous formulation of trastuzumab, assess the impact of…”
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Population pharmacokinetic and exposure–response analysis for trastuzumab administered using a subcutaneous “manual syringe” injection or intravenously in women with HER2-positive early breast cancer by Quartino, Angelica L., Hillenbach, Carina, Li, Jing, Li, Hanbin, Wada, Russell D., Visich, Jennifer, Li, Chunze, Heinzmann, Dominik, Jin, Jin Y., Lum, Bert L.

“…Purpose To characterize the population pharmacokinetics (PKs) of subcutaneous (SC) and intravenous (IV) trastuzumab in early breast cancer (EBC), assess the…”
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Pharmacokinetic Properties of a Sufentanil Sublingual Tablet Intended to Treat Acute Pain by Fisher, Dennis M, Chang, Peter, Wada, D Russell, Dahan, Albert, Palmer, Pamela P

“…BACKGROUND:Desirable product attributes for treatment of moderate-to-severe acute pain in many medically supervised settings are rapid onset and a route of…”
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Pharmacodynamics of orally administered sustained-release hydromorphone in humans by ANGST, Martin S, DROVER, David R, LÖTSCH, Jörn, RAMASWAMY, Bhamini, NAIDU, Sujata, WADA, D. Russell, STANSKI, Donald R

“…The disposition kinetics of hydromorphone generally necessitates oral administration every 4 h of the conventional immediate-release tablet to provide…”
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Population pharmacokinetic and covariate analysis of pertuzumab, a HER2-targeted monoclonal antibody, and evaluation of a fixed, non-weight-based dose in patients with a variety of solid tumors by Garg, Amit, Quartino, Angelica, Li, Jing, Jin, Jin, Wada, D. Russell, Li, Hanbin, Cortés, Javier, McNally, Virginia, Ross, Graham, Visich, Jennifer, Lum, Bert

“…Purpose To characterize the population pharmacokinetics (PK) of pertuzumab across clinical trials in a variety of solid tumors, evaluate the potential impact…”
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Pharmacokinetic and exposure–response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer by Quartino, Angelica L., Li, Hanbin, Jin, Jin Y., Wada, D. Russell, Benyunes, Mark C., McNally, Virginia, Viganò, Lucia, Nijem, Ihsan, Lum, Bert L., Garg, Amit

“…Purpose The NeoSphere trial evaluated pertuzumab in the neoadjuvant setting [early breast cancer (EBC)] with pathological complete response (pCR) as the…”
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Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 by Budha, Nageshwar R., Leabman, Maya, Jin, Jin Y., Wada, D. Russell, Baruch, Amos, Peng, Kun, Tingley, Whittemore G., Davis, John D.

“…ABSTRACT RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low density lipoprotein cholesterol (LDLc) levels. RG7652…”
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Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-Analysis by Cepeda, M. Soledad, Berlin, Jesse A., Gao, C. Yuying, Wiegand, Frank, Wada, D. Russell

“…Objective.  To compare placebo responses in neuropathic pain syndromes. Design.  Systematic literature review and meta‐analysis. Setting and Patients. …”
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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans by WADA, D. R, BJÖRKMAN, S, EBLING, W. F, HARASHIMA, H, HARAPAT, S. R, STANSKI, D. R

“…Understanding the influence of physiological variables on thiopental pharmacokinetics would enhance the scientific basis for the clinical usage of this…”
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Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients by BJÖRKMAN, S, WADA, D. R, STANSKI, D. R

“…The influence of changes in the physiologic state of a patient on the disposition of fentanyl and alfentanil is poorly understood. The aims of this study were…”
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Population pharmacokinetics of olmesartan following oral administration of its prodrug, olmesartan medoxomil : In healthy volunteers and hypertensive patients by YOSHIHARA, Kazutaka, YUYING GAO, SHIGA, Hiroshi, WADA, D. Russell, HISAOKA, Masafumi

“…Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly selective for the AT1 receptor subtype. To develop a…”
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Enriched analgesic efficacy studies: An assessment by clinical trial simulation by Lemmens, Hendrikus J.M., Wada, D. Russell, Munera, Catherine, Eltahtawy, Ahmed, Stanski, Donald R.

“…Enrichment strategies which select subjects who appear to respond to the drug have been used in drug studies to demonstrate clinical efficacy. We have used…”
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Determination of the distribution volume that can be used to calculate the intravenous loading dose by WADA, D. R, DROVER, D. R, LEMMENS, H. J. M

“…An intravenous loading dose is given to rapidly achieve a desired drug concentration in the blood. A loading dose calculated with the volume of distribution…”
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Development of a population pharmacokinetic (PPK) model of intravenous (IV) trastuzumab in patients with a variety of solid tumors to support dosing and treatment recommendations by Kirschbrown, Whitney Paige, Quartino, Angelica Linnea, Li, Hanbin, Mangat, Ranvir, Wada, D Russell, Garg, Amit, Jin, Jin Y, Lum, Bert L.

“…Abstract only 2525 Background: The aim of this analysis was to develop a PPK model for IV trastuzumab (Herceptin), to assess the impact of patient covariates…”
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Effects of thiopental on regional blood flows in the rat by WADA, D. R, HARASHIMA, H, EBLING, W. F, OSAKI, E. W, STANSKI, D. R

“…The goal of this investigation was to characterize the effects of thiopental on cardia output and regional blood flows in the rat. Blood flows influence…”
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Closed-loop stability of pharmacokinetic-pharmacodynamic models by Russell Wada, D.

“…In automatic feedback control of intravenous drug infusions, convergence to the setpoint is an important objective. This paper examines the stability of…”
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Open loop control of multiple drug effects in anesthesia by Wada, D.R., Ward, D.S.

“…Current open-loop computer-controlled infusion pumps do not explicitly control the transient adverse side effects of intravenous drugs during anesthesia. The…”
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No effect of age on the dose requirement of thiopental in the rat by Harashima, Hideyoshi, Ebling, William F., Russell Wada, D., Stanski, Donald R.

“…With increasing human age (20–80 years), the electroencephalogram (EEG) dose requirement for the intravenous anesthetic thiopental decreases approximately 10%…”
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Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic model by Björkman, S, Wada, D R, Berling, B M, Benoni, G

“…The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and…”
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The hybrid model: a new pharmacokinetic model for computer-controlled infusion pumps by Wada, D.R., Ward, D.S.

“…Classical pharmacokinetic models used in computer-controlled infusion pumps (CCIPs) assume instantaneous mixing of drug in blood; however, the average…”
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