Search Results - "Wackers, Paul F K"

The Arabidopsis SUMO E3 ligase SIZ1 mediates the temperature dependent trade-off between plant immunity and growth by Hammoudi, Valentin, Fokkens, Like, Beerens, Bas, Vlachakis, Georgios, Chatterjee, Sayantani, Arroyo-Mateos, Manuel, Wackers, Paul F K, Jonker, Martijs J, van den Burg, Harrold A

“…Increased ambient temperature is inhibitory to plant immunity including auto-immunity. SNC1-dependent auto-immunity is, for example, fully suppressed at 28°C…”
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A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens by Schaap, Mirjam M., Wackers, Paul F. K., Zwart, Edwin P., Huijskens, Ilse, Jonker, Martijs J., Hendriks, Giel, Breit, Timo M., van Steeg, Harry, van de Water, Bob, Luijten, Mirjam

“…Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for…”
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Confounding Factors in the Transcriptome Analysis of an In-Vivo Exposure Experiment by Bruning, Oskar, Rodenburg, Wendy, Wackers, Paul F K, van Oostrom, Conny, Jonker, Martijs J, Dekker, Rob J, Rauwerda, Han, Ensink, Wim A, de Vries, Annemieke, Breit, Timo M

“…In transcriptomics experimentation, confounding factors frequently exist alongside the intended experimental factors and can severely influence the outcome of…”
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Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs by Jonker, Martijs J., Melis, Joost P. M., Kuiper, Raoul V., Hoeven, Tessa V., Wackers, Paul F. K., Robinson, Joke, Horst, Gijsbertus T. J., Dollé, Martijn E. T., Vijg, Jan, Breit, Timo M., Hoeijmakers, Jan H. J., Steeg, Harry

“…Summary Aging and age‐related pathology is a result of a still incompletely understood intricate web of molecular and cellular processes. We present a C57BL/6J…”
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Relevance of In Vitro Transcriptomics for In Vivo Mode of Action Assessment by Luijten, Mirjam, Wackers, Paul F. K, Rorije, Emiel, Pennings, Jeroen L. A, Heusinkveld, Harm J

“…Recently, we reported an in vitro toxicogenomics comparison approach to categorize chemical substances according to similarities in their proposed…”
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Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes by Schaap, Mirjam M., Zwart, Edwin P., Wackers, Paul F. K., Huijskens, Ilse, van de Water, Bob, Breit, Timo M., van Steeg, Harry, Jonker, Martijs J., Luijten, Mirjam

“…Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is based on in vitro and in vivo genotoxicity assays…”
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A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment by Van Dycke, Kirsten C. G., Nijman, Romana M., Wackers, Paul F. K., Jonker, Martijs J., Rodenburg, Wendy, van Oostrom, Conny T. M., Salvatori, Daniela C. F., Breit, Timo M., van Steeg, Harry, Luijten, Mirjam, van der Horst, Gijsbertus T. J.

“…Application of omics-based technologies is a widely used approach in research aiming to improve testing strategies for human health risk assessment. In most of…”
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The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients by Fraszczyk, Eliza, Luijten, Mirjam, Spijkerman, Annemieke M W, Snieder, Harold, Wackers, Paul F K, Bloks, Vincent W, Nicoletti, Carolina F, Nonino, Carla B, Crujeiras, Ana B, Buurman, Wim A, Greve, Jan Willem, Rensen, Sander S, Wolffenbuttel, Bruce H R, van Vliet-Ostaptchouk, Jana V

“…Severe obesity is a growing, worldwide burden and conventional therapies including radical change of diet and/or increased physical activity have limited…”
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Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map by de Leeuw, Victoria C., Hessel, Ellen V.S., Pennings, Jeroen L.A., Hodemaekers, Hennie M., Wackers, Paul F.K., van Oostrom, Conny T.M., Piersma, Aldert H.

“…•The in vitro neural embryonic stem cell test (ESTn) mimics neural differentiation.•A cell lineage map of neural differentiation tracks gene expression of cell…”
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Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs by Keizers, Peter H.J., Bakker, Frank, Ferreira, José, Wackers, Paul F.K., van Kollenburg, Dion, van der Aa, Eva, van Beers, Amy

“…We have assessed an analytical method for the analysis of active ingredients in pharmaceutical products and illegal drugs, based on benchtop NMR spectroscopy…”
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Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq by de Leeuw, Victoria C., van Oostrom, Conny T.M., Wackers, Paul F.K., Pennings, Jeroen L.A., Hodemaekers, Hennie M., Piersma, Aldert H., Hessel, Ellen V.S.

“…There is an increased awareness that the use of animals for compound-induced developmental neurotoxicity (DNT) testing has limitations. Animal-free…”
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Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment by Heusinkveld, Harm J., Wackers, Paul F.K., Schoonen, Willem G., van der Ven, Leo, Pennings, Jeroen L.A., Luijten, Mirjam

“…Mode of action information is one of the key components for chemical risk assessment as mechanistic insight leads to better understanding of potential adverse…”
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Valuable lessons-learned in transcriptomics experimentation by Bruning, Oskar, Rauwerda, Han, Dekker, Rob J, de Leeuw, Wim C, Wackers, Paul F K, Ensink, Wim A, Jonker, Martijs J, Breit, Timo M

“…We have collected several valuable lessons that will help improve transcriptomics experimentation. These lessons relate to experiment design, execution, and…”
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