Search Results - "Wachi, Hiroshi"

7‐Ketocholesterol‐induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress by Sudo, Ryo, Sato, Fumiaki, Azechi, Takuya, Wachi, Hiroshi

“…Vascular calcification is known to reduce the elasticity of aorta. Several studies have suggested that autophagy–lysosomal pathway (ALP) in vascular smooth…”
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MiR‐29‐mediated elastin down‐regulation contributes to inorganic phosphorus‐induced osteoblastic differentiation in vascular smooth muscle cells by Sudo, Ryo, Sato, Fumiaki, Azechi, Takuya, Wachi, Hiroshi

“…Vascular calcification increases the risk of cardiovascular mortality. We previously reported that expression of elastin decreases with progression of…”
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IsoChichibabin desmosine-13C3,15N1 synthesis and quantitative LC-MS/MS analysis of desmosine and isodesmosine in human skin by Hirose, Mika, Kobayashi, Toyoaki, Tanaka, Nao, Mikagi, Ayame, Wachi, Hiroshi, Mizutani, Yuki, Usuki, Toyonobu

“…ga1. [Display omitted] Desmosine and isodesmosine are crosslinking amino acids of elastin, which is an essential component of the dermal extracellular matrix…”
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Lysyl Oxidase Enhances the Deposition of Tropoelastin through the Catalysis of Tropoelastin Molecules on the Cell Surface by Sato, Fumiaki, Seino-Sudo, Ryo, Okada, Mami, Sakai, Hiroyasu, Yumoto, Tetsuro, Wachi, Hiroshi

“…The cross-linking of elastin by lysyl oxidase (LOX) family members is essential for the integrity and elasticity of elastic fibers, which play an important…”
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5-aza-2´-Deoxycytidine, a DNA Methyltransferase Inhibitor, Facilitates the Inorganic Phosphorus-Induced Mineralization of Vascular Smooth Muscle Cells by Azechi, Takuya, Sato, Fumiaki, Sudo, Ryo, Wachi, Hiroshi

“…Aim: Vascular calcification, an independent risk factor for cardiovascular disease in patients with chronic kidney disease(CKD), refers to the mineralization…”
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Domain 36 of Tropoelastin in Elastic Fiber Formation by Nonaka, Risa, Sato, Fumiaki, Wachi, Hiroshi

“…Elastic fiber assembly is a complex stepwise process involving multiple different proteins and enzymes. Domain 36, encoded by the last exon of the elastin…”
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Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E by Ishikawa, Kazuki, Sato, Fumiaki, Itabashi, Takeshi, Wachi, Hiroshi, Takeda, Hisashi, Wakana, Daigo, Yaguchi, Takashi, Kawai, Ken-ichi, Hosoe, Tomoo

“…Seven novel spiromeroterpenoids, asnovolins A–G (1–7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus…”
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Trichostatin A, an HDAC Class I/II Inhibitor, Promotes Pi-Induced Vascular Calcification Via Up-Regulation of the Expression of Alkaline Phosphatase by Azechi, Takuya, Kanehira, Dan, Kobayashi, Takashi, Sudo, Ryo, Nishimura, Akiko, Sato, Fumiaki, Wachi, Hiroshi

“…Aim: Vascular calcification, a major complication of chronic kidney disease (CKD), refers to the mineralization of vascular smooth muscle cells (VSMCs),…”
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Accumulation of Elafin in Actinic Elastosis of Sun-Damaged Skin: Elafin Binds to Elastin and Prevents Elastolytic Degradation by Muto, Jun, Kuroda, Kei, Wachi, Hiroshi, Hirose, Shigehisa, Tajima, Shingo

“…Elafin has a primary structure with two functional domains; a transglutaminase substrate domain at the N-terminus and a protease inhibitor domain at the…”
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Role of Elastic Fibers on Cardiovascular Disease by Wachi, Hiroshi

“…An important factor in the transition from an open to a closed circulatory system was a change in vessel wall that are dynamic structure composed of cells and…”
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Direct evidence for the involvement of brain‐derived neurotrophic factor in the development of a neuropathic pain‐like state in mice by Yajima, Yoshinori, Narita, Minoru, Usui, Aiko, Kaneko, Chihiro, Miyatake, Mayumi, Narita, Michiko, Yamaguchi, Takanori, Tamaki, Hiroko, Wachi, Hiroshi, Seyama, Yoshiyuki, Suzuki, Tsutomu

“…Thermal hyperalgesia and tactile allodynia induced by sciatic nerve ligation were completely suppressed by repeated intrathecal (i.t.) injection of a TrkB/Fc…”
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Effect of β-agonist on the dexamethasone-induced expression of aromatase by the human monocyte cells by Watanabe, Masatada, Ohno, Shuji, Wachi, Hiroshi

“…Emerging evidence suggests that sex steroids are important for human skin health. In particular, estrogen improves skin thickness, elasticity and moisture of…”
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Galectin-7 and actin are components of amyloid deposit of localized cutaneous amyloidosis by Miura, Yoshinori, Harumiya, Satoru, Ono, Koji, Fujimoto, Eita, Akiyama, Minoru, Fujii, Noriko, Kawano, Hiroo, Wachi, Hiroshi, Tajima, Shingo

“…The precursor protein of localized cutaneous amyloidosis (LCA) is believed to be cytokeratins on the basis of previous immunohistochemical studies. To identify…”
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Distinct Steps of Cross-linking, Self-association, and Maturation of Tropoelastin Are Necessary for Elastic Fiber Formation by Sato, Fumiaki, Wachi, Hiroshi, Ishida, Marie, Nonaka, Risa, Onoue, Satoshi, Urban, Zsolt, Starcher, Barry C., Seyama, Yoshiyuki

“…Elastic fibers play an important role in the characteristic resilience of many tissues. The assembly of tropoelastin into a fibrillar matrix is a complex…”
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The cytotoxic and antifungal activities of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa by Wakana, Daigo, Hosoe, Tomoo, Wachi, Hiroshi, Itabashi, Takeshi, Fukushima, Kazutaka, Yaguchi, Takeshi, Kawai, Ken-ichi

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7-Ketocholesterol, a Major Oxysterol, Promotes Pi-Induced Vascular Calcification in Cultured Smooth Muscle Cells by Saito, Eiji, Wachi, Hiroshi, Sato, Fumiaki, Seyama, Yoshiyuki

“…Aim: Oxysterols are found in high concentrations in advanced atherosclerotic plaques and are considered as an important factor in the development of vascular…”
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Atherosclerosis and Matrix Dystrophy by Seyama, Yoshiyuki, Wachi, Hiroshi

“…Atherosclerosis is characterized by inflammatory metabolic change with lipid accumulation in the artery. Atherosclerotic plaque occurs at discrete locations in…”
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Characterization of the Molecular Interaction between Tropoelastin and DANCE/Fibulin-5 by Wachi, Hiroshi, Nonaka, Risa, Sato, Fumiaki, Shibata-Sato, Kayoko, Ishida, Marie, Iketani, Saori, Maeda, Iori, Okamoto, Koji, Urban, Zsolt, Onoue, Satoshi, Seyama, Yoshiyuki

“…Fibulin-5 is believed to play an important role in the elastic fiber formation. The present experiments were carried out to characterize the molecular…”
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DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner by Nonaka, Risa, Onoue, Satoshi, Wachi, Hiroshi, Sato, Fumiaki, Urban, Zsolt, Starcher, Barry C., Seyama, Yoshiyuki

“…To investigate a function of fibulin-5 in the elastic fiber formation, we studied the molecular interactions among elastin, fibrillin-1, and fibulin-5 in the…”
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Effects of Bidens pilosa L. var. radiata Scherff on experimental gastric lesion by Horiuchi, Masako, Wachi, Hiroshi, Seyama, Yoshiyuki

“…Bidens pilosa L. var. radiata S cherff (BP) is a plant used as a traditional folk medicine. BP, cultivated with only green manure on Miyako Island, Okinawa…”
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