Search Results - "Wabl, M."

DNA-PKcs Function Regulated Specifically by Protein Phosphatase 5 by Wechsler, Thomas, Benjamin P. C. Chen, Harper, Ryan, Morotomi-Yano, Keiko, Betty C. B. Huang, Meek, Katheryn, Cleaver, James E., Chen, David J., Wabl, Matthias

“…Unrepaired DNA double-strand breaks can lead to apoptosis or tumorigenesis. In mammals double-strand breaks are repaired mainly by nonhomologous end-joining…”
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VH gene replacement in hyperselected B cells of the quasimonoclonal mouse by Cascalho, M, Wong, J, Wabl, M

“…The primary repertoire of the quasimonoclonal mouse is monospecific. However, among peripheral B cells, there is a high frequency of variant cells with V(H)…”
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Association of SWAP-70 with the B Cell Antigen Receptor Complex by Masat, L., Caldwell, J., Armstrong, R., Khoshnevisan, H., Jessberger, R., Herndier, B., Wabl, M., Ferrick, D.

“…SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B…”
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Directed molecular evolution by somatic hypermutation by Wang, Clifford L., Yang, Desirée C., Wabl, Matthias

“…After rearrangement of immunoglobulin gene segments, the immune system evolves the antibody repertoire by mutating the immunoglobulin variable region at a high…”
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The Possibility of B‐Cell‐Dependent T‐Cell Development by Keshavarzi, S., Rietz, C., Simões, S., Shih, S., Platt, J. L., Wong, J., Wabl, M., Cascalho, M.

“…The development of T cells is thought to be independent of B cells. However, defects in cell‐mediated immunity in individuals with B‐cell deficiency suggest…”
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Enhancers of hypermutation by Bachl, J, Wabl, M

“…Hypermutation at the immunoglobulin (Ig) loci increases the mutation rate more than 10(5)-fold over the normal, spontaneous rate. We studied two kinds of…”
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Hypermutation at the Immunoglobulin Heavy Chain Locus in a Pre-B-Cell Line by Wabl, Matthias, Burrows, Peter D., Von Gabain, Alex, Steinberg, Charles

“…Most cells in the well-known pre-B-lymphocyte line 18-81 have correctly assembled genes for both alleles at the immunoglobulin heavy chain locus. Only one…”
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Expression of Immunoglobulin Heavy Chain at a High Level in the Absence of a Proposed Immunoglobulin Enhancer Element in cis by Wabl, Matthias R., Burrows, Peter D.

“…The major intron between the J and C gene segments of the immunoglobulin heavy (H) chain locus contains an enhancer-like sequence, and it has been proposed…”
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VH Gene Replacement in Thymocytes by Golub, Rachel, Martin, Denise, Bertrand, Fred E, Cascalho, Marilia, Wabl, Matthias, Wu, Gillian E

“…The quasi-monoclonal (QM) mouse has a functionally rearranged H chain gene inserted into its natural position in the IgH locus. In this position, the H chain…”
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An immunoglobulin mutator that targets G.C base pairs by Bachl, J, Wabl, M

“…Hypermutation can be defined as an enhancement of the spontaneous mutation rate which the organism uses in certain types of differentiated cells where a high…”
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Immunoglobulin mRNA stability varies during B lymphocyte differentiation by Jäck, H. M., Wabl, M.

“…During differentiation of B lymphocytes, the change in the amount of immunoglobulin heavy chain produced is reflected by a change in the steady state level of…”
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A Theory of Allelic and Isotypic Exclusion for Immunoglobulin Genes by Wabl, Matthias, Steinberg, Charles

“…Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the μ and γ classes, can be demonstrated in pre-B-cells. It is proposed…”
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A Video Technique for the Quantification of DNA in Gels Stained with Ethidium Bromide by Harriman, W.D., Wabl, M.

“…We have developed a method for the comparison of quantitative differences between nucleic acid samples run on agarose gels. It is useful for the analysis of…”
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Looping out and Deletion Mechanism for the Immunoglobulin Heavy-Chain Class Switch by Jäck, Hans-Martin, McDowell, Mindy, Steinberg, Charles M., Wabl, Matthias

“…In the mouse pre-B-cell line 18-81, cells can switch production in vitro from immunoglobulin μ chain to γ 2b chain. The gene encoding the γ 2b chain is created…”
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A Simpler Sort of Antibody by Masat, Linda, Wabl, Matthias, Johnson, Judith P.

“…The monoclonal antibody NEMO is directed against a molecule expressed by human cells of the melanocytic lineage. Although obtained by conventional immunization…”
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Mapping of the SWAP70 gene to mouse chromosome 7 and human chromosome 11p15 by Masat, L, Liddell, R A, Mock, B A, Kuo, W L, Jessberger, R, Wabl, M, Morse, 3rd, H C

“…The protein SWAP-70 was isolated as part of a DNA recombination complex in B lymphocytes, where it is predominantly expressed. In resting B cells, SWAP-70 is…”
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Genome-Wide Somatic Hypermutation by Wang, Clifford L., Harper, Ryan A., Wabl, Matthias, Weigert, Martin G.

“…DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially…”
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Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse by Wabl, Matthias, Gerdes, Tobias

“…Lymphocytes typically express only one functional antigen receptor, a restriction contributed to by allelic exclusion. Here we have analyzed B lymphocyte…”
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High Rate of Somatic Point Mutation in vitro in and near the Variable-Region Segment of an Immunoglobulin Heavy Chain Gene by Meyer, Jutta, Jäck, Hans-Martin, Ellis, Nina, Wabl, Matthias

“…The ``silent'' allele at the immunoglobulin heavy-chain locus in the pre-B-lymphocyte line 18-81 contains a correctly assembled gene. However, an amber…”
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Tumorigenesis Mediated by an Antigen Receptor by Jack, Hans-Martin, Beck-Engeser, Gabriele, Lee, Gary, Wofsy, David, Wabl, Matthias

“…The heavy chain variable region of the immunoglobulin receptors on cells of the B lymphoma NYC are almost identical to that of other independent B-cell tumors…”
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