Search Results - "Waard, Vivian"
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1
Marfan on the Move
Published in Journal of the American Heart Association (25-09-2017)Get full text
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2
The Risk for Type B Aortic Dissection in Marfan Syndrome
Published in Journal of the American College of Cardiology (27-01-2015)“…Abstract Background Aortic dissections involving the descending aorta are a major clinical problem in patients with Marfan syndrome. Objectives The purpose of…”
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3
Pregnancy and Thoracic Aortic Disease: Managing the Risks
Published in Canadian journal of cardiology (2016)“…Abstract The most common aortopathies in women of childbearing age are bicuspid aortic valve, coarctation of the aorta, Marfan syndrome, Ehlers-Danlos…”
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4
S100A9 Links Inflammation and Repair in Myocardial Infarction
Published in Circulation research (14-08-2020)“…RATIONALE:The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory…”
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5
A cross‐sectional study on fatigue, anxiety, and symptoms of depression and their relation with medical status in adult patients with Marfan syndrome. Psychological consequences in Marfan syndrome
Published in Clinical genetics (01-11-2022)“…Marfan syndrome (MFS) is a connective tissue disorder affecting the cardiovascular, ocular, and skeletal system, which may be accompanied by psychological…”
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6
Growth charts for Marfan syndrome in the Netherlands and analysis of genotype–phenotype relationships
Published in American journal of medical genetics. Part A (01-02-2023)“…To optimize care for children with Marfan syndrome (MFS) in the Netherlands, Dutch MFS growth charts were constructed. Additionally, we aimed to investigate…”
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Endothelial dysfunction in Marfan syndrome mice is restored by resveratrol
Published in Scientific reports (28-12-2022)“…Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell…”
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Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells
Published in Nature communications (13-05-2024)“…Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive…”
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9
Clinical Features Differ Substantially Between Caucasian and Asian Populations of Marfan Syndrome
Published in Circulation Journal (2013)“…Background: Prevention of aortic dissection and sudden death in patients with Marfan syndrome (MFS) requires accurate diagnosis. MFS is diagnosed by the Ghent…”
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10
Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients
Published in Arteriosclerosis, thrombosis, and vascular biology (01-09-2019)“…OBJECTIVE:Marfan syndrome (MFS) is caused by mutations in FBN1 (fibrillin-1), an extracellular matrix (ECM) component, which is modified post-translationally…”
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11
Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis
Published in Circulation research (03-02-2012)“…RATIONALE:Nuclear receptor Nur77, also known as NR4A1, TR3, or NGFI-B, is expressed in human atherosclerotic lesions in macrophages, endothelial cells, T cells…”
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12
The Potential Beneficial Effects of Resveratrol on Cardiovascular Complications in Marfan Syndrome Patients⁻Insights from Rodent-Based Animal Studies
Published in International journal of molecular sciences (05-03-2019)“…Marfan syndrome (MFS) patients are at risk for cardiovascular disease. In particular, for aortic aneurysm formation, which ultimately can result in a…”
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13
Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
Published in The Journal of experimental medicine (14-02-2011)“…Growth differentiation factor (GDF) 15 is a member of the transforming growth factor β (TGF-β) superfamily, which operates in acute phase responses through a…”
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14
A Novel Hypothesis: A Role for Follicle Stimulating Hormone in Abdominal Aortic Aneurysm Development in Postmenopausal Women
Published in Frontiers in endocrinology (Lausanne) (13-10-2021)“…An abdominal aortic aneurysm (AAA) is a dilatation of the abdominal aorta, which can potentially be fatal due to exsanguination following rupture. Although AAA…”
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Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes
Published in International journal of molecular sciences (05-02-2021)“…Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture,…”
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Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels
Published in Arteriosclerosis, thrombosis, and vascular biology (01-02-2008)“…OBJECTIVE—The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and…”
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6-Mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1
Published in Inflammatory bowel diseases (01-09-2014)“…Inflammatory bowel disease is characterized by chronic intestinal inflammation. Azathioprine and its metabolite 6-mercaptopurine (6-MP) are effective…”
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Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome
Published in Cell reports (Cambridge) (18-09-2018)“…Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression…”
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Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques
Published in PloS one (30-11-2017)“…Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel…”
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Inadequate detection of the FSHR complicates future research on extragonadal FSHR localization
Published in Frontiers in endocrinology (Lausanne) (16-02-2023)“…Recently, follicle stimulating hormone (FSH) through interaction with its receptor (FSHR) has been proposed to play a role in postmenopausal osteoporosis and…”
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