Search Results - "Waanders, Esme"

High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer by Diets, Illja J, Waanders, Esmé, Ligtenberg, Marjolijn J, van Bladel, Diede A G, Kamping, Eveline J, Hoogerbrugge, Peter M, Hopman, Saskia, Olderode-Berends, Maran J, Gerkes, Erica H, Koolen, David A, Marcelis, Carlo, Santen, Gijs W, van Belzen, Martine J, Mordaunt, Dylan, McGregor, Lesley, Thompson, Elizabeth, Kattamis, Antonis, Pastorczak, Agata, Mlynarski, Wojciech, Ilencikova, Denisa, van Silfhout, Anneke Vulto, Gardeitchik, Thatjana, de Bont, Eveline S, Loeffen, Jan, Wagner, Anja, Mensenkamp, Arjen R, Kuiper, Roland P, Hoogerbrugge, Nicoline, Jongmans, Marjolijn C

“…In many children with cancer and characteristics suggestive of a genetic predisposition syndrome, the genetic cause is still unknown. We studied the yield of…”
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Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations by Antić, Željko, Yu, Jiangyan, Van Reijmersdal, Simon V, Van Dijk, Anke, Dekker, Linde, Segerink, Wouter H, Sonneveld, Edwin, Fiocco, Marta, Pieters, Rob, Hoogerbrugge, Peter M, Van Leeuwen, Frank N, Van Kessel, Ad Geurts, Waanders, Esme, Kuiper, Roland P

“…Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring…”
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Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL by van der Veer, Arian, Waanders, Esmé, Pieters, Rob, Willemse, Marieke E., Van Reijmersdal, Simon V., Russell, Lisa J., Harrison, Christine J., Evans, William E., van der Velden, Vincent H.J., Hoogerbrugge, Peter M., Van Leeuwen, Frank, Escherich, Gabriele, Horstmann, Martin A., Mohammadi Khankahdani, Leila, Rizopoulos, Dimitris, De Groot-Kruseman, Hester A., Sonneveld, Edwin, Kuiper, Roland P., Den Boer, Monique L.

“…Most relapses in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are not predicted using current prognostic features. Here, we determined the…”
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Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool by Jongmans, Marjolijn C.J, Loeffen, Jan L.C.M, Waanders, Esmé, Hoogerbrugge, Peter M, Ligtenberg, Marjolijn J.L, Kuiper, Roland P, Hoogerbrugge, Nicoline

“…Abstract Genetic predisposition for childhood cancer is under diagnosed. Identifying these patients may lead to therapy adjustments in case of syndrome-related…”
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Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs by Dobson, Stephanie M, García-Prat, Laura, Vanner, Robert J, Wintersinger, Jeffrey, Waanders, Esmé, Gu, Zhaohui, McLeod, Jessica, Gan, Olga I, Grandal, Ildiko, Payne-Turner, Debbie, Edmonson, Michael N, Ma, Xiaotu, Fan, Yiping, Voisin, Veronique, Chan-Seng-Yue, Michelle, Xie, Stephanie Z, Hosseini, Mohsen, Abelson, Sagi, Gupta, Pankaj, Rusch, Michael, Shao, Ying, Olsen, Scott R, Neale, Geoffrey, Chan, Steven M, Bader, Gary, Easton, John, Guidos, Cynthia J, Danska, Jayne S, Zhang, Jinghui, Minden, Mark D, Morris, Quaid, Mullighan, Charles G, Dick, John E

“…Disease recurrence causes significant mortality in B-progenitor acute lymphoblastic leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples…”
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Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors by Sabatella, Mariangela, Mantere, Tuomo, Waanders, Esmé, Neveling, Kornelia, Mensenkamp, Arjen R, Dijk, Freerk, Hehir‐Kwa, Jayne Y, Derks, Ronnie, Kwint, Michael, O'Gorman, Luke, Tropa Martins, Madalena, Gidding, Corrie EM, Lequin, Maarten H, Küsters, Benno, Wesseling, Pieter, Nelen, Marcel, Biegel, Jacklyn A, Hoischen, Alexander, Jongmans, Marjolijn C, Kuiper, Roland P

“…In a subset of pediatric cancers, a germline cancer predisposition is highly suspected based on clinical and pathological findings, but genetic evidence is…”
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TRIM28 haploinsufficiency predisposes to Wilms tumor by Diets, Illja J., Hoyer, Juliane, Ekici, Arif B., Popp, Bernt, Hoogerbrugge, Nicoline, Reijmersdal, Simon V., Bhaskaran, Rajith, Hadjihannas, Michel, Vasileiou, Georgia, Thiel, Christian T., Seven, Didem, Uebe, Steffen, Ilencikova, Denisa, Waanders, Esmé, Mavinkurve‐Groothuis, Annelies M.C., Roeleveld, Nel, Krijger, Ronald R., Wegert, Jenny, Graf, Norbert, Vokuhl, Christian, Agaimy, Abbas, Gessler, Manfred, Reis, André, Kuiper, Roland P., Jongmans, Marjolijn C.J., Metzler, Markus

“…Two percent of patients with Wilms tumors have a positive family history. In many of these cases the genetic cause remains unresolved. By applying germline…”
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Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels by Mullighan, Charles G., Jeha, Sima, Pei, Deqing, Payne-Turner, Debbie, Coustan-Smith, Elaine, Roberts, Kathryn G., Waanders, Esmé, Choi, John K., Ma, Xiaotu, Raimondi, Susana C., Fan, Yiping, Yang, Wenjian, Song, Guangchun, Yang, Jun J., Inaba, Hiroto, Downing, James R., Leung, Wing H., Bowman, W. Paul, Relling, Mary V., Evans, William E., Zhang, Jinghui, Campana, Dario, Pui, Ching-Hon

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Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia by Waanders, Esmé, Gu, Zhaohui, Dobson, Stephanie M., Antić, Željko, Crawford, Jeremy Chase, Ma, Xiaotu, Edmonson, Michael N., Payne-Turner, Debbie, van de Vorst, Maartje, Jongmans, Marjolijn C.J., McGuire, Irina, Zhou, Xin, Wang, Jian, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Song, Guangchun, Fan, Yiping, Shao, Ying, Rusch, Michael, McCastlain, Kelly, Yu, Jiangyan, van Boxtel, Ruben, Blokzijl, Francis, Iacobucci, Ilaria, Roberts, Kathryn G., Wen, Ji, Wu, Gang, Ma, Jing, Easton, John, Neale, Geoffrey, Olsen, Scott R., Nichols, Kim E., Pui, Ching-Hon, Zhang, Jinghui, Evans, William E., Relling, Mary V., Yang, Jun J., Thomas, Paul G., Dick, John E., Kuiper, Roland P., Mullighan, Charles G.

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De Novo and Inherited Pathogenic Variants in KDM3B Cause Intellectual Disability, Short Stature, and Facial Dysmorphism by Diets, Illja J., van der Donk, Roos, Baltrunaite, Kristina, Waanders, Esmé, Reijnders, Margot R.F., Dingemans, Alexander J.M., Pfundt, Rolph, Vulto-van Silfhout, Anneke T., Wiel, Laurens, Gilissen, Christian, Thevenon, Julien, Perrin, Laurence, Afenjar, Alexandra, Nava, Caroline, Keren, Boris, Bartz, Sarah, Peri, Bethany, Beunders, Gea, Verbeek, Nienke, van Gassen, Koen, Thiffault, Isabelle, Cadieux-Dion, Maxime, Huerta-Saenz, Lina, Wagner, Matias, Konstantopoulou, Vassiliki, Vodopiutz, Julia, Griese, Matthias, Boel, Annekatrien, Callewaert, Bert, Brunner, Han G., Kleefstra, Tjitske, Hoogerbrugge, Nicoline, de Vries, Bert B.A., Hwa, Vivian, Dauber, Andrew, Hehir-Kwa, Jayne Y., Kuiper, Roland P., Jongmans, Marjolijn C.J.

“…By using exome sequencing and a gene matching approach, we identified de novo and inherited pathogenic variants in KDM3B in 14 unrelated individuals and three…”
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Heterozygosity for bisphosphoglycerate mutase deficiency expressing clinically as congenital erythrocytosis: A case series and literature review by Dijk, Myrthe J., Oirschot, Brigitte A., Stam‐Slob, Manon C., Waanders, Esmé, Zwaag, Bert, Beers, Eduard J., Jans, Judith J. M., Linden, Peter Willem, Torregrosa Diaz, Jose M., Gardie, Betty, Girodon, François, Schots, Rik, Thielen, Noortje, Wijk, Richard

“…Summary Erythrocytosis is associated with increased red blood cell mass and can be either congenital or acquired. Congenital secondary causes are rare and…”
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The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution by Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T, van Reijmersdal, Simon V, van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M, van Kessel, Ad Geurts, van Leeuwen, Frank N, Kuiper, Roland P

“…Recurrent submicroscopic deletions in genes affecting key cellular pathways are a hallmark of pediatric acute lymphoblastic leukemia (ALL). To gain more…”
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A RAG driver on the road to pediatric ALL by Kuiper, Roland P, Waanders, Esmé

“…Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing…”
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On the monophyly of chromalveolates using a six-protein phylogeny of eukaryotes by Harper, James T, Waanders, Esme, Keeling, Patrick J

“…Canadian Institute for Advanced Research, Department of Botany, University of British Columbia, 3529-6270 University Boulevard, Vancouver, BC, Canada V6T 1Z4…”
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European standard clinical practice – Key issues for the medical care of individuals with familial leukemia by Förster, Alisa, Davenport, Claudia, Duployez, Nicolas, Erlacher, Miriam, Ferster, Alina, Fitzgibbon, Jude, Göhring, Gudrun, Hasle, Henrik, Jongmans, Marjolijn C., Kolenova, Alexandra, Kronnie, Geertruijte, Lammens, Tim, Mecucci, Cristina, Mlynarski, Wojciech, Niemeyer, Charlotte M., Sole, Francesc, Szczepanski, Tomasz, Waanders, Esmé, Biondi, Andrea, Wlodarski, Marcin, Schlegelberger, Brigitte, Ripperger, Tim

“…Although hematologic malignancies (HM) are no longer considered exclusively sporadic, additional awareness of familial cases has yet to be created. Individuals…”
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Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype–genotype study by Helenius, Marianne, Vaitkeviciene, Goda, Abrahamsson, Jonas, Jonsson, Ólafur Gisli, Lund, Bendik, Harila‐Saari, Arja, Vettenranta, Kim, Mikkel, Sirje, Stanulla, Martin, Lopez‐Lopez, Elixabet, Waanders, Esmé, Madsen, Hans O., Marquart, Hanne Vibeke, Modvig, Signe, Gupta, Ramneek, Schmiegelow, Kjeld, Nielsen, Rikke Linnemann

“…Background White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well‐known prognostic factor in acute lymphoblastic leukemia…”
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Clonal dynamics in pediatric B‐cell precursor acute lymphoblastic leukemia with very early relapse by Antić, Željko, Yu, Jiangyan, Bornhauser, Beat C., Lelieveld, Stefan H., Ham, Cedric G., Reijmersdal, Simon V., Morgado, Lionel, Elitzur, Sarah, Bourquin, Jean‐Pierre, Cazzaniga, Giovanni, Eckert, Cornelia, Camós, Mireia, Sutton, Rosemary, Cavé, Hélène, Moorman, Anthony V., Sonneveld, Edwin, Geurts van Kessel, Ad, Leeuwen, Frank N., Hoogerbrugge, Peter M., Waanders, Esmé, Kuiper, Roland P.

“…Introduction One‐quarter of the relapses in children with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) occur very early (within 18 months, before…”
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Accurate detection of low-level mosaic mutations in pediatric acute lymphoblastic leukemia using single molecule tagging and deep-sequencing by Yu, Jiangyan, Antić, Željko, van Reijmersdal, Simon V., Hoischen, Alexander, Sonneveld, Edwin, Waanders, Esmé, Kuiper, Roland P.

“…Pathogenic mutations in relapse-associated genes in pediatric acute lymphoblastic leukemia may improve risk stratification when detected at subclonal levels at…”
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Late Recurrence of Childhood T-Cell Acute Lymphoblastic Leukemia Frequently Represents a Second Leukemia Rather Than a Relapse: First Evidence for Genetic Predisposition by SZCZEPANSKI, Tomasz, VAN DER VELDEN, Vincent H. J, ZUR STADT, Udo, CAMPANA, Dario, SCHRAUDER, André, SUTTON, Rosemary, VAN WERING, Elisabeth, MEIJERINK, Jules P. P, VAN DONGEN, Jacques J. M, WAANDERS, Esmé, KUIPER, Roland P, VAN VLIERBERGHE, Pieter, GRUHN, Bernd, ECKERT, Cornelia, PANZER-GRÜMAYER, Renate, BASSO, Giuseppe, CAVE, Hélène

“…Relapse of childhood T-cell acute lymphoblastic leukemia (T-ALL) often occurs during treatment, but in some cases, leukemia re-emerges off therapy. On the…”
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Congenital disorders of glycosylation in hepatology: The example of polycystic liver disease by Janssen, Manoe J, Waanders, Esmé, Woudenberg, Jannes, Lefeber, Dirk J, Drenth, Joost P.H

“…Autosomal dominant polycystic liver disease (PCLD) is a rare progressive disorder characterized by an increased liver volume due to many (>20) fluid-filled…”
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