Search Results - "Waanders, Angela J"

Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways by Surrey, Lea F, Jain, Payal, Zhang, Bo, Straka, Joshua, Zhao, Xiaonan, Harding, Brian N, Resnick, Adam C, Storm, Phillip B, Buccoliero, Anna Maria, Genitori, Lorenzo, Li, Marilyn M, Waanders, Angela J, Santi, Mariarita

“…Abstract Dysembryoplastic neuroepithelial tumors (DNT) lacking key diagnostic criteria are challenging to diagnose and sometimes fall into the broader category…”
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Clinical utility of custom-designed NGS panel testing in pediatric tumors by Surrey, Lea F, MacFarland, Suzanne P, Chang, Fengqi, Cao, Kajia, Rathi, Komal S, Akgumus, Gozde T, Gallo, Daniel, Lin, Fumin, Gleason, Adam, Raman, Pichai, Aplenc, Richard, Bagatell, Rochelle, Minturn, Jane, Mosse, Yael, Santi, Mariarita, Tasian, Sarah K, Waanders, Angela J, Sarmady, Mahdi, Maris, John M, Hunger, Stephen P, Li, Marilyn M

“…Somatic genetic testing is rapidly becoming the standard of care in many adult and pediatric cancers. Previously, the standard approach was single-gene or…”
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MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia by Jones, Courtney L., Gearheart, Christy M., Fosmire, Susan, Delgado-Martin, Cristina, Evensen, Nikki A., Bride, Karen, Waanders, Angela J., Pais, Faye, Wang, Jinhua, Bhatla, Teena, Bitterman, Danielle S., de Rijk, Simone R., Bourgeois, Wallace, Dandekar, Smita, Park, Eugene, Burleson, Tamara M., Madhusoodhan, Pillai Pallavi, Teachey, David T., Raetz, Elizabeth A., Hermiston, Michelle L., Müschen, Markus, Loh, Mignon L., Hunger, Stephen P., Zhang, Jinghui, Garabedian, Michael J., Porter, Christopher C., Carroll, William L.

“…The outcome for pediatric acute lymphoblastic leukemia (ALL) patients who relapse is dismal. A hallmark of relapsed disease is acquired resistance to multiple…”
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BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas by Olow, Aleksandra, Mueller, Sabine, Yang, Xiaodong, Hashizume, Rintaro, Meyerowitz, Justin, Weiss, William, Resnick, Adam C, Waanders, Angela J, Stalpers, Lukas J A, Berger, Mitchel S, Gupta, Nalin, James, C David, Petritsch, Claudia K, Haas-Kogan, Daphne A

“…Alteration of the BRAF/MEK/MAPK pathway is the hallmark of pediatric low-grade gliomas (PLGGs), and mTOR activation has been documented in the majority of…”
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Data standards in pediatric oncology: Past, present, and future by Wyatt, Kirk D., Noyd, David H., Wood, Nicole M., Phillips, Charles A., Miller, Tamara P., Rubin, Elyssa M., Winestone, Lena E., Waanders, Angela J., Perentesis, John P., Aplenc, Richard

“…In this commentary, we highlight the central role that data standards play in facilitating data‐driven efforts to advance research in pediatric oncology. We…”
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Whole Chromosome 7 Gain Predicts Higher Risk of Recurrence in Pediatric Pilocytic Astrocytomas Independently From KIAA1549-BRAF Fusion Status by Roth, Jacquelyn J., Fierst, Tamara M., Waanders, Angela J., Yimei, Li, Biegel, Jaclyn A., Santi, Mariarita

“…The most frequent genetic alteration identified in pediatric pilocytic astrocytomas and pilomyxoid variant is the KIAA1549-BRAF fusion, which typically results…”
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Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways by Jain, Payal, Silva, Amanda, Han, Harry J, Lang, Shih-Shan, Zhu, Yuankun, Boucher, Katie, Smith, Tiffany E, Vakil, Aesha, Diviney, Patrick, Choudhari, Namrata, Raman, Pichai, Busch, Christine M, Delaney, Tim, Yang, Xiaodong, Olow, Aleksandra K, Mueller, Sabine, Haas-Kogan, Daphne, Fox, Elizabeth, Storm, Phillip B, Resnick, Adam C, Waanders, Angela J

“…Pediatric low-grade gliomas (PLGGs) are frequently associated with activating gene fusions, such as KIAA1549-BRAF, that aberrantly drive the mitogen activated…”
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Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas by Ryall, Scott, Zapotocky, Michal, Fukuoka, Kohei, Nobre, Liana, Guerreiro Stucklin, Ana, Bennett, Julie, Siddaway, Robert, Li, Christopher, Pajovic, Sanja, Arnoldo, Anthony, Kowalski, Paul E., Johnson, Monique, Sheth, Javal, Lassaletta, Alvaro, Tatevossian, Ruth G., Orisme, Wilda, Qaddoumi, Ibrahim, Surrey, Lea F., Li, Marilyn M., Waanders, Angela J., Gilheeney, Stephen, Rosenblum, Marc, Bale, Tejus, Tsang, Derek S., Laperriere, Normand, Kulkarni, Abhaya, Ibrahim, George M., Drake, James, Dirks, Peter, Taylor, Michael D., Rutka, James T., Laughlin, Suzanne, Shroff, Manohar, Shago, Mary, Hazrati, Lili-Naz, D'Arcy, Colleen, Ramaswamy, Vijay, Bartels, Ute, Huang, Annie, Bouffet, Eric, Karajannis, Matthias A., Santi, Mariarita, Ellison, David W., Tabori, Uri, Hawkins, Cynthia

“…Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated protein kinase (RAS/MAPK) pathway yet show…”
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Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response by Foster, Jessica B, Choudhari, Namrata, Perazzelli, Jessica, Storm, Julie, Hofmann, Ted J, Jain, Payal, Storm, Phillip B, Pardi, Norbert, Weissman, Drew, Waanders, Angela J, Grupp, Stephan A, Karikó, Katalin, Resnick, Adam C, Barrett, David M

“…T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the…”
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A pilot precision medicine trial for children with diffuse intrinsic pontine glioma—PNOC003: A report from the Pacific Pediatric Neuro‐Oncology Consortium by Mueller, Sabine, Jain, Payal, Liang, Winnie S., Kilburn, Lindsay, Kline, Cassie, Gupta, Nalin, Panditharatna, Eshini, Magge, Suresh N., Zhang, Bo, Zhu, Yuankun, Crawford, John R., Banerjee, Anu, Nazemi, Kellie, Packer, Roger J., Petritsch, Claudia K., Truffaux, Nathalene, Roos, Alison, Nasser, Sara, Phillips, Joanna J., Solomon, David, Molinaro, Annette, Waanders, Angela J., Byron, Sara A., Berens, Michael E., Kuhn, John, Nazarian, Javad, Prados, Michael, Resnick, Adam C.

“…This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing (RNAseq) of paired normal and tumor tissues could be incorporated into a…”
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Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial by Mackay, Alan, Burford, Anna, Molinari, Valeria, Jones, David T.W., Izquierdo, Elisa, Brouwer-Visser, Jurriaan, Giangaspero, Felice, Haberler, Christine, Pietsch, Torsten, Jacques, Thomas S., Figarella-Branger, Dominique, Rodriguez, Daniel, Morgan, Paul S., Raman, Pichai, Waanders, Angela J., Resnick, Adam C., Massimino, Maura, Garrè, Maria Luisa, Smith, Helen, Capper, David, Pfister, Stefan M., Würdinger, Thomas, Tam, Rachel, Garcia, Josep, Thakur, Meghna Das, Vassal, Gilles, Grill, Jacques, Jaspan, Tim, Varlet, Pascale, Jones, Chris

“…The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with…”
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Pediatric low-grade gliomas: next biologically driven steps by Jones, David T W, Kieran, Mark W, Bouffet, Eric, Alexandrescu, Sanda, Bandopadhayay, Pratiti, Bornhorst, Miriam, Ellison, David, Fangusaro, Jason, Fisher, Michael J, Foreman, Nicholas, Fouladi, Maryam, Hargrave, Darren, Hawkins, Cynthia, Jabado, Nada, Massimino, Maura, Mueller, Sabine, Perilongo, Giorgio, Schouten van Meeteren, Antoinette Y N, Tabori, Uri, Warren, Katherine, Waanders, Angela J, Walker, David, Weiss, William, Witt, Olaf, Wright, Karen, Zhu, Yuan, Bowers, Daniel C, Pfister, Stefan M, Packer, Roger J

“…Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain a significant clinical challenge in pediatric neuro-oncology due…”
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Socioeconomic Factors Associated With Participation in Postmortem Tissue Donation in Pediatric Central Nervous System Tumors by Kabat, Judith M., Boland, Lauren K., Williams, Melissa, Michelson, Ian, Lenzen, Alicia, Plant‐Fox, Ashley S., Wadhwani, Nitin, Waanders, Angela J.

“…ABSTRACT Background The gift of postmortem tissue donation is critical to pediatric central nervous system (CNS) research. As a “Center of Excellence” for the…”
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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial by Kilburn, Lindsay B., Khuong-Quang, Dong-Anh, Hansford, Jordan R., Landi, Daniel, van der Lugt, Jasper, Leary, Sarah E. S., Driever, Pablo Hernáiz, Bailey, Simon, Perreault, Sébastien, McCowage, Geoffrey, Waanders, Angela J., Ziegler, David S., Witt, Olaf, Baxter, Patricia A., Kang, Hyoung Jin, Hassall, Timothy E., Han, Jung Woo, Hargrave, Darren, Franson, Andrea T., Yalon Oren, Michal, Toledano, Helen, Larouche, Valérie, Kline, Cassie, Abdelbaki, Mohamed S., Jabado, Nada, Gottardo, Nicholas G., Gerber, Nicolas U., Whipple, Nicholas S., Segal, Devorah, Chi, Susan N., Oren, Liat, Tan, Enrica E. K., Mueller, Sabine, Cornelio, Izzy, McLeod, Lisa, Zhao, Xin, Walter, Ashley, Da Costa, Daniel, Manley, Peter, Blackman, Samuel C., Packer, Roger J., Nysom, Karsten

“…BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 ( n  = 77) of the ongoing phase 2 FIREFLY-1…”
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The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science by Lilly, Jena V., Rokita, Jo Lynne, Mason, Jennifer L., Patton, Tatiana, Stefankiewiz, Stephanie, Higgins, David, Trooskin, Gerri, Larouci, Carina A., Arya, Kamnaa, Appert, Elizabeth, Heath, Allison P., Zhu, Yuankun, Brown, Miguel A., Zhang, Bo, Farrow, Bailey K., Robins, Shannon, Morgan, Allison M., Nguyen, Thinh Q., Frenkel, Elizabeth, Lehmann, Kaitlin, Drake, Emily, Sullivan, Catherine, Plisiewicz, Alexa, Coleman, Noel, Patterson, Luke, Koptyra, Mateusz, Helili, Zeinab, Van Kuren, Nicholas, Young, Nathan, Kim, Meen Chul, Friedman, Christopher, Lubneuski, Alex, Blackden, Christopher, Williams, Marti, Baubet, Valerie, Tauhid, Lamiya, Galanaugh, Jamie, Boucher, Katie, Ijaz, Heba, Cole, Kristina A., Choudhari, Namrata, Santi, Mariarita, Moulder, Robert W., Waller, Jonathan, Rife, Whitney, Diskin, Sharon J., Mateos, Marion, Parsons, Donald W., Pollack, Ian F., Goldman, Stewart, Leary, Sarah, Caporalini, Chiara, Buccoliero, Anna Maria, Scagnet, Mirko, Haussler, David, Hanson, Derek, Firestein, Ron, Cain, Jason, Phillips, Joanna J., Gupta, Nalin, Mueller, Sabine, Grant, Gerald, Monje-Deisseroth, Michelle, Partap, Sonia, Greenfield, Jeffrey P., Hashizume, Rintaro, Smith, Amy, Zhu, Shida, Johnston, James M., Fangusaro, Jason R., Miller, Matthew, Wood, Matthew D., Gardner, Sharon, Carter, Claire L., Prolo, Laura M., Pisapia, Jared, Pehlivan, Katherine, Franson, Andrea, Niazi, Toba, Rubin, Josh, Abdelbaki, Mohamed, Ziegler, David S., Lindsay, Holly B., Stucklin, Ana Guerreiro, Gerber, Nicolas, Vaske, Olena M., Quinsey, Carolyn, Rood, Brian R., Nazarian, Javad, Raabe, Eric, Jackson, Eric M., Stapleton, Stacie, Lober, Robert M., Kram, David E., Koschmann, Carl, Storm, Phillip B., Lulla, Rishi R., Prados, Michael, Resnick, Adam C., Waanders, Angela J.

“…Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential…”
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Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1) by Fisher, Michael J., Jones, David T. W., Li, Yimei, Guo, Xiaofan, Sonawane, Poonam S., Waanders, Angela J., Phillips, Joanna J., Weiss, William A., Resnick, Adam C., Gosline, Sara, Banerjee, Jineta, Guinney, Justin, Gnekow, Astrid, Kandels, Daniela, Foreman, Nicholas K., Korshunov, Andrey, Ryzhova, Marina, Massimi, Luca, Gururangan, Sri, Kieran, Mark W., Wang, Zhihong, Fouladi, Maryam, Sato, Mariko, Øra, Ingrid, Holm, Stefan, Markham, Stephen J., Beck, Pengbo, Jäger, Natalie, Wittmann, Andrea, Sommerkamp, Alexander C., Sahm, Felix, Pfister, Stefan M., Gutmann, David H.

“…Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general population and in individuals with the Neurofibromatosis type 1 (NF1) cancer…”
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Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers by Chang, Fengqi, Lin, Fumin, Cao, Kajia, Surrey, Lea F., Aplenc, Richard, Bagatell, Rochelle, Resnick, Adam C., Santi, Mariarita, Storm, Phillip B., Tasian, Sarah K., Waanders, Angela J., Hunger, Stephen P., Li, Marilyn M.

“…Gene fusions are one of the most common genomic alterations in pediatric cancer. Many fusions encode oncogenic drivers and play important roles in cancer…”
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Endoscopic third ventriculostomy prior to resection of posterior fossa tumors in children by Frisoli, Fabio, Kakareka, Michael, Cole, Kristina A., Waanders, Angela J, Storm, Phillip B., Lang, Shih-Shan

“…Objective Hydrocephalus is a common presenting symptom of pediatric posterior fossa tumors and often requires permanent cerebrospinal fluid diversion even…”
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A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study by DeWire, Mariko D, Fuller, Christine, Campagne, Olivia, Lin, Tong, Pan, Haitao, Young Poussaint, Tina, Baxter, Patricia A, Hwang, Eugene I, Bukowinski, Andrew, Dorris, Kathleen, Hoffman, Lindsey, Waanders, Angela J, Karajannis, Matthias A, Stewart, Clinton F, Onar-Thomas, Arzu, Fouladi, Maryam, Dunkel, Ira J

“…Genomic aberrations in cell cycle and PI3K pathways are commonly observed in pediatric brain tumors. This study determined the MTD/recommended phase II dose…”
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Immunotherapy for pediatric brain tumors: past and present by Foster, Jessica B, Madsen, Peter J, Hegde, Meenakshi, Ahmed, Nabil, Cole, Kristina A, Maris, John M, Resnick, Adam C, Storm, Phillip B, Waanders, Angela J

“…The field of cancer immunotherapy has progressed at an accelerated rate over the past decade. Pediatric brain tumors thus far have presented a formidable…”
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