Search Results - "WYSS, D. F"

Identification of the Major Positional Isomer of Pegylated Interferon Alpha-2b by Wang, Yu-Sen, Youngster, Stephen, Bausch, James, Zhang, Rumin, McNemar, Charles, Wyss, Daniel F

“…Interferons display a wide range of antiviral, antiproliferative, and immunomodulatory activities on a variety of cell types and have been used to treat many…”
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Conformation and Function of the N-Linked Glycan in the Adhesion Domain of Human CD2 by Wyss, Daniel F., Choi, Johnathan S., Li, Jing, Knoppers, Maria H., Willis, Kevin J., Antonio R. N. Arulanandam, Smolyar, Alex, Reinherz, Ellis L., Wagner, Gerhard

“…The adhesion domain of human CD2 bears a single N-linked carbohydrate. The solution structure of a fragment of CD2 containing the covalently bound high-mannose…”
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Alignment of weakly interacting molecules to protein surfaces using simulations of chemical shift perturbations by McCoy, M A, Wyss, D F

“…Structural studies of protein-ligand complexes are often limited by low solubility, poor affinity, and interfacial motion and, in NMR structures, by the lack…”
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The CD58 (LFA-3) Binding Site is a Localized and Highly Charged Surface Area on the AGFCC'C'' Face of the Human CD2 Adhesion Domain by Antonio R. N. Arulanandam, Withka, Jane M., Wyss, Daniel F., Wagner, Gerhard, Kister, Alexander, Pallai, Peter, Recny, Michael A., Reinherz, Ellis L.

“…Using site-directed mutagenesis in conjunction with NMR structural data on the adhesion domain of human CD2, we have defined the binding region for CD58…”
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The counterreceptor binding site of human CD2 exhibits an extended surface patch with multiple conformations fluctuating with millisecond to microsecond motions by Wyss, Daniel F., Dayie, Kwaku T., Wagner, Gerhard

“…We have used 15N NMR relaxation experiments to probe, for the glycosylated human CD2 adhesion domain, the overall molecular motion, as well as very fast…”
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Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments by Wyss, D F, Lahm, H W, Manneberg, M, Labhardt, A M

“…Anantin, a naturally occurring peptide from Streptomyces coerulescens, binds competitively to the receptor of atrial natriuretic factor (ANF) from bovine…”
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Flexible Lid to the p53-Binding Domain of Human Mdm2: Implications for p53 Regulation by McCoy, Mark A., Gesell, Jennifer J., Senior, Mary M., Wyss, Daniel F.

“…The stabilization of p53 against Mdm2-mediated degradation is an important event in DNA damage response. Initial models of p53 stabilization focused on…”
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Structure, biology, and therapeutic implications of pegylated interferon alpha-2b by Youngster, Stephen, Wang, Yu-Sen, Grace, Michael, Bausch, James, Bordens, Ronald, Wyss, Daniel F

“…Derivatization of protein-based therapeutics with polyethylene glycol (pegylation) can often improve pharmacokinetic and pharmacodynamic properties of the…”
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The structural role of sugars in glycoproteins by Wyss, Daniel F, Wagner, Gerhard

“…To date, high resolution X-ray structures of about 30 glycoproteins have been reported that provide some structural information on glycans. Four solution…”
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Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex by McCoy, Mark A, Senior, Mary M, Gesell, Jennifer J, Ramanathan, Lata, Wyss, Daniel F

“…The backbone assignments, secondary structure, topology, and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex have been…”
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Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase by Liu, D, Wang, Y S, Gesell, J J, Wyss, D F

“…The NS3 protein of the hepatitis C virus (HCV) is a 631 amino acid residue bifunctional enzyme with a serine protease localized to the N-terminal 181 residues…”
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Composition and sequence specific resonance assignments of the heterogeneous N-linked glycan in the 13.6 kDa adhesion domain of human CD2 as determined by NMR on the intact glycoprotein by Wyss, D F, Choi, J S, Wagner, G

“…CD2, a T cell specific surface adhesion receptor, is critically important for T lymphocytes to mediate their regulatory and effector functions. The amino…”
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Cell surface adhesion receptors by Wagner, G, Wyss, D F

“…Several new structural motifs found in cell surface adhesion receptors have been described in the past few years. Also, several two-domain structures of…”
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Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor by Wagner, Gerhard, Hare, Brian J, Wyss, Daniel F, Osburne, Marcia S, Kern, Petra S, Reinherz, Ellis L

“…Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC)…”
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Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2 by Withka, J M, Wyss, D F, Wagner, G, Arulanandam, A R, Reinherz, E L, Recny, M A

“…CD2, a T-cell specific surface glycoprotein, is critically important for mediating adherence of T cells to antigen-presenting cells or target cells. Domain 1…”
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Interaction between human CD2 and CD58 involves the major beta sheet surface of each of their respective adhesion domains by Arulanandam, A R, Kister, A, McGregor, M J, Wyss, D F, Wagner, G, Reinherz, E L

“…The CD58 binding site on human CD2 was recently shown by nuclear magnetic resonance structural data in conjunction with site-directed mutagenesis to be a…”
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Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies by Gesell, Jennifer J., Liu, Dingjiang, Madison, Vincent S., Hesson, Thomas, Wang, Yu-Sen, Weber, Patricia C., Wyss, Daniel F.

“…RNA helicases represent a family of enzymes that unwind double-stranded (ds) RNA in a nucleoside triphosphate (NTP)-dependent fashion and which are required in…”
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Conformational Integrity and Ligand Binding Properties of a Single Chain T-cell Receptor Expressed in Escherichia coli by Khandekar, Sanjay S., Bettencourt, Brian M., Wyss, Daniel F., Naylor, Jerome W., Brauer, Pamela P., Huestis, Kevin, Dwyer, Donard S., Profy, Albert T., Osburne, Marcia S., Banerji, Julian, Jones, Barry

“…We recently showed that a soluble, heterodimeric murine D10 T-cell receptor (TCR) (Vα2Cα, Vβ8.2Cβ) expressed in insect cells binds both Vβ8.2-specific…”
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1H resonance assignments and secondary structure of the 13.6 kDa glycosylated adhesion domain of human CD2 by WYSS, D. F, WITHKA, J. M, KNOPPERS, M. H, STERNE, K. A, RECNY, M. A, WAGNER, G

“…Human CD2, a glycosylated transmembrane receptor found on all T-lymphocytes, plays a key role in facilitating cellular adhesion between T-cells and target…”
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Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications by Wang, Yu-Sen, Youngster, Stephen, Grace, Michael, Bausch, James, Bordens, Ronald, Wyss, Daniel F.

“…The type I interferon alpha family consists of small proteins that have clinically important anti-infective and anti-tumor activity. Interferon alpha-2b…”
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