Search Results - "WYNES, Murry W"

An international interpretation study using the ALK IHC antibody D5F3 and a sensitive detection kit demonstrates high concordance between ALK IHC and ALK FISH and between evaluators by Wynes, Murry W, Sholl, Lynette M, Dietel, Manfred, Schuuring, Ed, Tsao, Ming S, Yatabe, Yasushi, Tubbs, Raymond R, Hirsch, Fred R

“…The goal of personalized medicine is to treat patients with a therapy predicted to be efficacious based on the molecular characteristics of the tumor, thereby…”
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The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation-Positive Non-Small Cell Lung Cancer: Status in 2016 by Tan, Daniel S W, Yom, Sue S, Tsao, Ming S, Pass, Harvey I, Kelly, Karen, Peled, Nir, Yung, Rex C, Wistuba, Ignacio I, Yatabe, Yasushi, Unger, Michael, Mack, Philip C, Wynes, Murry W, Mitsudomi, Tetsuya, Weder, Walter, Yankelevitz, David, Herbst, Roy S, Gandara, David R, Carbone, David P, Bunn, Jr, Paul A, Mok, Tony S K, Hirsch, Fred R

“…Mutations in the epidermal growth factor receptor gene (EGFR) represent one of the most frequent "actionable" alterations in non-small cell lung cancer…”
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Correlation between MET gene copy number by silver in situ hybridization and protein expression by immunohistochemistry in non-small cell lung cancer by Dziadziuszko, Rafal, Wynes, Murry W, Singh, Shalini, Asuncion, Bernadette Reyna, Ranger-Moore, James, Konopa, Krzysztof, Rzyman, Witold, Szostakiewicz, Barbara, Jassem, Jacek, Hirsch, Fred R

“…The MET receptor is involved in the pathogenesis and progression of non-small cell lung cancer (NSCLC). Clinical trials with MET inhibitors in NSCLC are…”
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The mTOR pathway in lung cancer and implications for therapy and biomarker analysis by Ekman, Simon, Wynes, Murry W, Hirsch, Fred R

“…Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulatory protein in normal cell growth, survival, metabolism,…”
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The tissue is the issue: personalized medicine for non-small cell lung cancer by Hirsch, Fred R, Wynes, Murry W, Gandara, David R, Bunn, Jr, Paul A

“…The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of…”
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Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer by Salido, Marta, Pijuan, Lara, Martínez-Avilés, Luz, Galván, Ana B, Cañadas, Israel, Rovira, Ana, Zanui, Montserrat, Martínez, Alejandro, Longarón, Raquel, Sole, Francisco, Serrano, Sergio, Bellosillo, Beatriz, Wynes, Murry W, Albanell, Joan, Hirsch, Fred R, Arriola, Edurne

“…Translocation of the anaplastic lymphoma kinase (ALK) gene is involved in the tumorigenesis of a subset of non-small cell lung carcinomas (NSCLCs) and…”
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Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as a possible screening method for epidermal growth factor receptor mutations by Kato, Yasufumi, Peled, Nir, Wynes, Murry W, Yoshida, Koichi, Pardo, Marta, Mascaux, Celine, Ohira, Tatsuo, Tsuboi, Masahiro, Matsubayashi, Jun, Nagao, Toshitaka, Ikeda, Norihiko, Hirsch, Fred R

“…Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) predict better outcome to EGFR tyrosine kinase inhibitors. The most…”
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Natural History and Real-World Treatment Outcomes for Patients With NSCLC Having EGFR Exon 20 Insertion Mutation: An International Association for the Study of Lung Cancer–American Society of Clinical Oncology CancerLinQ Study by Behera, Madhusmita, Jiang, Renjian, Huang, Zhonglu, Bunn, Becky, Wynes, Murry W., Switchenko, Jeffrey, Scagliotti, Giorgio V., Belani, Chandra P., Ramalingam, Suresh S.

“…EGFR exon 20 insertion (ex20ins) mutations account for approximately 10% of EGFR mutations in lung adenocarcinoma. Patients with ex20ins mutation do not…”
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Contributions of KRAS and RAL in non-small-cell lung cancer growth and progression by Guin, Sunny, Ru, Yuanbin, Wynes, Murry W, Mishra, Rangnath, Lu, Xian, Owens, Charles, Barn, Anna E, Vasu, Vihas T, Hirsch, Fred R, Kern, Jeffrey A, Theodorescu, Dan

“…KRAS mutations are poor prognostic markers for patients with non-small-cell lung cancer (NSCLC). RALA and RALB GTPases lie downstream of RAS and are implicated…”
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Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis by Wynes, Murry W, Edelman, Benjamin L, Kostyk, Amanda G, Edwards, Michael G, Coldren, Christopher, Groshong, Steve D, Cosgrove, Gregory P, Redente, Elizabeth F, Bamberg, Alison, Brown, Kevin K, Reisdorph, Nichole, Keith, Rebecca C, Frankel, Stephen K, Riches, David W H

“…Idiopathic pulmonary fibrosis (IPF) is associated with the accumulation of collagen-secreting fibroblasts and myofibroblasts in the lung parenchyma. Many…”
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EGFR Protein Expression in Non-Small Cell Lung Cancer Predicts Response to an EGFR Tyrosine Kinase Inhibitor―A Novel Antibody for Immunohistochemistry or AQUA Technology by MASCAUX, Celine, WYNES, Murry W, NAGAO, Toshitaka, YOSHIDA, Koichi, OHIRA, Tatuso, IKEDA, Norihiko, HIRSCH, Fred R, KATO, Yasufumi, TRAN, Cindy, ASUNCION, Bernadette Reyna, ZHAO, Jason M, GUSTAVSON, Mark, RANGER-MOORE, Jim, GAIRE, Fabien, MATSUBAYASHI, Jun

“…Epidermal growth factor receptor (EGFR) protein expression in non-small cell lung cancer (NSCLC) is not recommended for predicting response to EGFR tyrosine…”
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Independent validation test of the vote-counting strategy used to rank biomarkers from published studies by Rikke, Brad A, Wynes, Murry W, Rozeboom, Leslie M, Barón, Anna E, Hirsch, Fred R

“…Vote counting is frequently used in meta-analyses to rank biomarker candidates, but to our knowledge, there have been no independent assessments of its…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…- In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the…”
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Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology by Lindeman, Neal I, Cagle, Philip T, Aisner, Dara L, Arcila, Maria E, Beasley, Mary Beth, Bernicker, Eric H, Colasacco, Carol, Dacic, Sanja, Hirsch, Fred R, Kerr, Keith, Kwiatkowski, David J, Ladanyi, Marc, Nowak, Jan A, Sholl, Lynette, Temple-Smolkin, Robyn, Solomon, Benjamin, Souter, Lesley H, Thunnissen, Erik, Tsao, Ming S, Ventura, Christina B, Wynes, Murry W, Yatabe, Yasushi

“…In 2013, an evidence-based guideline was published by the College of American Pathologists, the International Association for the Study of Lung Cancer, and the…”
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Early detection and screening of lung cancer by Mascaux, Celine, Peled, Nir, Garg, Kavita, Kato, Yasufumi, Wynes, Murry W, Hirsch, Fred R

“…Accounting for 28% of all cancer deaths and causing 1.3 million deaths worldwide every year, lung cancer is the most lethal cancer. Diagnosing and treating…”
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Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer by Wynes, Murry W, Konopa, Krzysztof, Singh, Shalini, Reyna-Asuncion, Bernadette, Ranger-Moore, James, Sternau, Adam, Christoph, Daniel C, Dziadziuszko, Rafal, Jassem, Jacek, Hirsch, Fred R

“…Increased expression of thymidylate synthase (TS) is thought to be associated with resistance to TS-targeting drugs, e.g., pemetrexed. TS protein expression…”
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IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal by Wynes, Murry W., Frankel, Stephen K., Riches, David W. H.

“…The development of idiopathic pulmonary fibrosis (IPF) is associated with myofibroblast accumulation and collagen deposition in the lung parenchyma. Recent…”
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The International Association for the Study of Lung Cancer Global Survey on Molecular Testing in Lung Cancer by Smeltzer, Matthew P, Wynes, Murry W, Lantuejoul, Sylvie, Soo, Ross, Ramalingam, Suresh S, Varella-Garcia, Marileila, Meadows Taylor, Meghan, Richeimer, Kristin, Wood, Kelsey, Howell, Kristen E, Dalurzo, Mercedes Lilana, Felip, Enriqueta, Hollenbeck, Gina, Kerr, Keith, Kim, Edward S, Mathias, Clarissa, Pacheco, Jose, Postmus, Pieter, Powell, Charles, Tsuboi, Masahiro, Wistuba, Ignacio I, Wakelee, Heather A, Belani, Chandra P, Scagliotti, Giorgio V, Hirsch, Fred R

“…Access to targeted therapies for lung cancer depends on the accurate identification of patients' biomarkers through molecular testing. The International…”
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Treatment Guidance for Patients With Lung Cancer During the Coronavirus 2019 Pandemic by Dingemans, Anne-Marie C, Soo, Ross A, Jazieh, Abdul Rahman, Rice, Shawn J, Kim, Young Tae, Teo, Lynette L S, Warren, Graham W, Xiao, Shu-Yuan, Smit, Egbert F, Aerts, Joachim G, Yoon, Soon Ho, Veronesi, Giulia, De Cobelli, Francesco, Ramalingam, Suresh S, Garassino, Marina C, Wynes, Murry W, Behera, Madhusmita, Haanen, John, Lu, Shun, Peters, Solange, Ahn, Myung-Ju, Scagliotti, Giorgio V, Adjei, Alex A, Belani, Chandra P

“…The global coronavirus disease 2019 pandemic continues to escalate at a rapid pace inundating medical facilities and creating substantial challenges globally…”
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