Search Results - "WYLD, P"

Photodynamic therapy for cancer of the pancreas by Bown, S G, Rogowska, A Z, Whitelaw, D E, Lees, W R, Lovat, L B, Ripley, P, Jones, L, Wyld, P, Gillams, A, Hatfield, A W R

“…Background: Few pancreatic cancers are suitable for surgery and few respond to chemoradiation. Photodynamic therapy produces local necrosis of tissue with…”
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Serum HER-2/neu and Response to the Aromatase Inhibitor Letrozole Versus Tamoxifen by LIPTON, A, ALI, S. M, LEITZEL, K, DEMERS, L, HARVEY, H. A, CHAUDRI-ROSS, H. A, BRADY, C, WYLD, P, CARNEY, W

“…To determine the effect of elevated serum HER-2/neu on the response of metastatic breast cancer patients to an aromatase inhibitor versus an antiestrogen. Five…”
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Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects by Savcic, M, Hauert, J, Bachmann, F, Wyld, P J, Geudelin, B, Cariou, R

“…Clopidogrel, a potent novel platelet ADP-receptor antagonist, induces a significant inhibition of ADP-induced platelet aggregation. Maximum inhibition of 40 to…”
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Arimidex (ZD1033): a selective, potent inhibitor of aromatase in postmenopausal female volunteers by Yates, R A, Dowsett, M, Fisher, G V, Selen, A, Wyld, P J

“…Two multiple-dose studies were conducted in healthy post-menopausal female volunteers to investigate the pharmacokinetics and effects on endocrinology of…”
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Arimidex (ZD1033) : a selective, potent inhibitor of aromatase in post-menopausal female volunteers by YATES, R. A, DOWSETT, M, FISHER, G. V, SELEN, A, WYLD, P. J

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Pharmacokinetics of valsartan in patients with liver disease by Brookman, Laurence J., Rolan, Paul E., Benjamin, Irving S., Palmer, Kelvin R., Wyld, Peter J., Lloyd, Peter, Flesch, Gérard, Waldmeier, Felix, Sioufi, Antoine, Mullins, Frank

“…Objectives Valsartan (CGP 48933), an orally active angiotensin II antagonist, is eliminated mainly by hepatic clearance. To characterize the compound(s)…”
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Twenty-eight-day Double-blind Safety Study of an HFA-134a Inhalation Aerosol System in Healthy Subjects by HARRISON, LESTER I., DONNELL, DAVID, SIMMONS, JEAN L., EKHOLM, BRUCE P., COOPER, KATHERINE M., WYLD, PETER J.

“…A 28‐day double‐blind parallel group study has been conducted to compare the safety and tolerability of HFA‐134a, a chlorofluorocarbon‐free propellant in a…”
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Phase III Study of Letrozole Versus Tamoxifen as First-Line Therapy of Advanced Breast Cancer in Postmenopausal Women: Analysis of Survival and Update of Efficacy From the International Letrozole Breast Cancer Group by MOURIDSEN, Henning, GERSHANOVICH, Mikhail, PLUZANSKA, Anna, DANK, Magdolna, BECQUART, Dominique, BAPSY, Poonamalle P, SALMINEN, Eeva, SNYDER, Ray, CHAUDRI-ROSS, Hilary, LANG, Raquel, WYLD, Peter, BHATNAGAR, Ajay, SUN, Yan, PEREZ-CARRION, Ramon, BONI, Corrado, MONNIER, Alain, APFFELSTAEDT, Justus, SMITH, Robert, SLEEBOOM, Harm P, JAENICKE, Fritz

“…To analyze overall survival (OS) and update efficacy data for letrozole versus tamoxifen as first-line therapy in postmenopausal women with locally advanced or…”
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The importance of general practitioner information in selection of volunteers for clinical trials by Watson, N, Wyld, PJ

“…The safe conduct of phase I volunteer studies requires careful selection and screening of volunteers. We have reviewed the results of the selection procedure…”
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The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers by BROCKS, D. R, UPWARD, J. W, GEORGIOU, P, STELMAN, G, DOYLE, E, ALLEN, E, WYLD, P, DENNIS, M. J

“…The pharmacokinetics of pranlukast, a leukotriene LTD4 antagonist, were studied in 48 young, healthy subjects after single and repeated oral doses (given every…”
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Pharmacokinetics and biochemical efficacy of idrapril calcium, a novel ACE inhibitor, after multiple oral administration in humans by Wyld, PJ, Grant, J, Lippi, A, Criscuoli, M, Re, G, Subissi, A

“…The pharmacokinetic profile and biochemical efficacy of idrapril calcium, a novel angiotensin converting enzyme (ACE) inhibitor, were evaluated in healthy…”
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Temafloxacin does not potentiate the anticoagulant effect of warfarin in healthy subjects by Millar, E, Coles, S, Wyld, P, Nimmo, W

“…The potential for drug interaction between temafloxacin, a new fluorinated quinolone antibiotic, and low-intensity warfarin was studied in 10 healthy male…”
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Phase I--study with aprosulate, a new synthetic anticoagulant by Papoulias, U E, Wyld, P J, Haas, S, Stemberger, A, Jeske, W, Hoppensteadt, D, Kämmereit, A

“…This paper describes the first human study with aprosulate, a new chemically synthesized anticoagulant with a defined molecular structure and a molecular…”
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Effect of repeated Aprosulate and Enoxaparin administration on tissue factor pathway inhibitor antigen levels by Jeske, W, Hoppensteadt, D, Klauser, R, Kammereit, A, Eckenberger, P, Haas, S, Wyld, P, Fareed, J

“…Tissue factor pathway inhibitor (TFPI) is a naturally occurring, Kunitz-type serine protease inhibitor whose anticoagulant activity is due to an inhibition of…”
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Sporadic HTLV-I associated adult T-cell leukaemia (ATL) in the U.K by Wyld, P J, Tosswill, J H, Mortimer, P P, Weber, J N

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Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL by Johnson, S, Smith, A G, Löffler, H, Osby, E, Juliusson, G, Emmerich, B, Wyld, P J, Hiddemann, W

“…Fludarabine seems to be a promising treatment for patients with advanced chronic lymphocytic leukaemia (CLL). We compared fludarabine therapy with the…”
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Does multisomy of chromosome 1q confer a proliferative advantage in B-cell acute lymphoblastic leukemia? by Morris, C M, Fitzgerald, P H, Neville, M A, Wyld, P J, Beard, M E

“…Two patients fulfilled the clinical and hematologic criteria for B-cell acute lymphoblastic leukemia: the malignant cells had L3 morphology, bore B-cell…”
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Computer dosing in anticoagulant clinics--the way forward? by Wyld, P J, West, D, Wilson, T H

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Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin by Preston, F E, Whipps, S, Jackson, C A, French, A J, Wyld, P J, Stoddard, C J

“…To compare the inhibitory effects of aspirin on prostaglandin synthesized by vessel walls and platelets, we obtained vein segments from five subjects before…”
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Compound sodium lactate (Hartmann's) solution. Caution: risk of clotting by Edwards, M P, Clark, D J, Mark, J S, Wyld, P J

“…We have observed blood clotting in blood administration sets where Hartmann's solution (Travenol) has preceded blood transfusion. This is due to calcium ions…”
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