Search Results - "WURFEL, M. M"

Covid-19 in Critically Ill Patients in the Seattle Region — Case Series by Bhatraju, Pavan K, Ghassemieh, Bijan J, Nichols, Michelle, Kim, Richard, Jerome, Keith R, Nalla, Arun K, Greninger, Alexander L, Pipavath, Sudhakar, Wurfel, Mark M, Evans, Laura, Kritek, Patricia A, West, T. Eoin, Luks, Andrew, Gerbino, Anthony, Dale, Chris R, Goldman, Jason D, O’Mahony, Shane, Mikacenic, Carmen

“…Clinicians and investigators report on the first 24 patients admitted to ICUs from nine Seattle area hospitals. Key aspects of the clinical presentation,…”
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Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies by Lee, Seunggeun, Emond, Mary J., Bamshad, Michael J., Barnes, Kathleen C., Rieder, Mark J., Nickerson, Deborah A., Christiani, David C., Wurfel, Mark M., Lin, Xihong

“…We propose in this paper a unified approach for testing the association between rare variants and phenotypes in sequencing association studies. This approach…”
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Archaic Hominin Admixture Facilitated Adaptation to Out-of-Africa Environments by Gittelman, Rachel M., Schraiber, Joshua G., Vernot, Benjamin, Mikacenic, Carmen, Wurfel, Mark M., Akey, Joshua M.

“…As modern humans dispersed from Africa throughout the world, they encountered and interbred with archaic hominins, including Neanderthals and Denisovans [1,…”
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TLRs in COVID-19: How they drive immunopathology and the rationale for modulation by Mabrey, F. Linzee, Morrell, Eric D, Wurfel, Mark M

“…COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious…”
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Identification and characterization of a loss-of-function human MPYS variant by Jin, L, Xu, L-g, Yang, I V, Davidson, E J, Schwartz, D A, Wurfel, M M, Cambier, J C

“…MPYS, also known as STING and MITA, is an interferon (IFN)β stimulator essential for host defense against RNA, DNA viruses and intracellular bacteria. MPYS…”
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Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis by Trinder, Mark, Wang, Yanan, Madsen, Christian M., Ponomarev, Tatjana, Bohunek, Lubos, Daisely, Brendan A., Julia Kong, HyeJin, Blauw, Lisanne L., Nordestgaard, Børge G., Tybjærg-Hansen, Anne, Wurfel, Mark M., Russell, James A., Walley, Keith R., Rensen, Patrick C.N., Boyd, John H., Brunham, Liam R.

“…The high-density lipoprotein hypothesis of atherosclerosis has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors,…”
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Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome by Esposito, Anthony J, Bhatraju, Pavan K, Stapleton, Renee D, Wurfel, Mark M, Mikacenic, Carmen

“…Hyaluronic acid (HA), an extracellular matrix component, is degraded in response to local tissue injury or stress. In various animal models of lung injury, HA…”
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Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis by Reilly, John P., Wang, Fan, Jones, Tiffanie K., Palakshappa, Jessica A., Anderson, Brian J., Shashaty, Michael G. S., Dunn, Thomas G., Johansson, Erik D., Riley, Thomas R., Lim, Brian, Abbott, Jason, Ittner, Caroline A. G., Cantu, Edward, Lin, Xihong, Mikacenic, Carmen, Wurfel, Mark M., Christiani, David C., Calfee, Carolyn S., Matthay, Michael A., Christie, Jason D., Feng, Rui, Meyer, Nuala J.

“…Purpose A causal biomarker for acute respiratory distress syndrome (ARDS) could fuel precision therapy options. Plasma angiopoietin-2 (ANG2), a vascular…”
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Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness by Martin, Thomas R., Wurfel, Mark M., Zanoni, Ivan, Ulevitch, Richard

“…The SARS-CoV-2 pandemic has produced an unprecedented rush to develop new therapies, ranging from immunizations and antivirals to host-directed therapies to…”
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Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome by Jones, Tiffanie K, Feng, Rui, Kerchberger, V Eric, Reilly, John P, Anderson, Brian J, Shashaty, Michael G S, Wang, Fan, Dunn, Thomas G, Riley, Thomas R, Abbott, Jason, Ittner, Caroline A G, Christiani, David C, Mikacenic, Carmen, Wurfel, Mark M, Ware, Lorraine B, Calfee, Carolyn S, Matthay, Michael A, Christie, Jason D, Meyer, Nuala J

“…Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products)…”
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Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness by Mikacenic, Carmen, Hahn, William O, Price, Brenda L, Harju-Baker, Susanna, Katz, Ronit, Kain, Kevin C, Himmelfarb, Jonathan, Liles, W Conrad, Wurfel, Mark M

“…Endothelial activation plays a role in organ dysfunction in the systemic inflammatory response syndrome (SIRS). Angiopoietin-1 (Ang-1) promotes vascular…”
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Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19 by Holton, Sarah E, Mitchem, Mallorie, Chalian, Hamid, Pipavath, Sudhakar, Morrell, Eric D, Bhatraju, Pavan K, Hamerman, Jessica A, Speake, Cate, Malhotra, Uma, Wurfel, Mark M, Ziegler, Steven E, Mikacenic, Carmen

“…Acute respiratory distress syndrome (ARDS) has a fibroproliferative phase that may be followed by pulmonary fibrosis. Pulmonary fibrosis following COVID-19…”
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Th17 cells are associated with protection from ventilator associated pneumonia by Orlov, Marika, Dmyterko, Victoria, Wurfel, Mark M, Mikacenic, Carmen

“…CD4+ T-helper 17 (Th17) cells and Interleukin (IL)-17A play an important role in clearing pathogens in mouse models of pneumonia. We hypothesized that numbers…”
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Inflammatory Basis of Exercise-induced Bronchoconstriction by Hallstrand, Teal S, Moody, Mark W, Wurfel, Mark M, Schwartz, Lawrence B, Henderson, William R., Jr, Aitken, Moira L

“…Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ…”
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Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study by Bhatraju, Pavan K, Morrell, Eric D, Zelnick, Leila, Sathe, Neha A, Chai, Xin-Ya, Sakr, Sana S, Sahi, Sharon K, Sader, Anthony, Lum, Dawn M, Liu, Ted, Koetje, Neall, Garay, Ashley, Barnes, Elizabeth, Lawson, Jonathan, Cromer, Gail, Bray, Mary K, Pipavath, Sudhakar, Kestenbaum, Bryan R, Liles, W Conrad, Fink, Susan L, West, T Eoin, Evans, Laura, Mikacenic, Carmen, Wurfel, Mark M

“…Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct…”
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Endotracheal aspirates contain a limited number of lower respiratory tract immune cells by Orlov, Marika, Morrell, Eric D, Dmyterko, Victoria, Hamerman, Jessica A, Wurfel, Mark M, Mikacenic, Carmen

“…[...]there is a paucity of information regarding whether ETAs are a reasonable surrogate for bronchoalveolar lavage (BAL) to study lung specific immune…”
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MCP-1 Gene Activation Marks Acute Kidney Injury by MUNSHI, Raj, JOHNSON, Ali, SIEW, Edward D, ALP IKIZLER, T, WARE, Lorraine B, WURFEL, Mark M, HIMMELFARB, Jonathan, ZAGER, Richard A

“…Monocyte chemoattractant protein 1 (MCP-1) mediates acute ischemic and toxic kidney injury, but whether this can be used as a biomarker of acute kidney injury…”
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Genetic insights into sepsis: what have we learned and how will it help? by Wurfel, M M

“…Sepsis and septic shock, are complex disorders that are a major cause of mortality in the intensive care unit. In spite of major advances in our understanding…”
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The transcriptional and phenotypic characteristics that define alveolar macrophage subsets in acute hypoxemic respiratory failure by Morrell, Eric D., Holton, Sarah E., Lawrance, Matthew, Orlov, Marika, Franklin, Zoie, Mitchem, Mallorie A., DeBerg, Hannah, Gersuk, Vivian H., Garay, Ashley, Barnes, Elizabeth, Liu, Ted, Peltan, Ithan D., Rogers, Angela, Ziegler, Steven, Wurfel, Mark M., Mikacenic, Carmen

“…The transcriptional and phenotypic characteristics that define alveolar monocyte and macrophage subsets in acute hypoxemic respiratory failure (AHRF) are…”
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The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness by Reilly, John P, Meyer, Nuala J, Shashaty, Michael Gs, Anderson, Brian J, Ittner, Caroline, Dunn, Thomas G, Lim, Brian, Forker, Caitlin, Bonk, Michael P, Kotloff, Ethan, Feng, Rui, Cantu, Edward, Mangalmurti, Nilam S, Calfee, Carolyn S, Matthay, Michael A, Mikacenic, Carmen, Walley, Keith R, Russell, James, Christiani, David C, Wurfel, Mark M, Lanken, Paul N, Reilly, Muredach P, Christie, Jason D

“…BACKGROUNDThe ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases, including acute respiratory…”
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