Search Results - "WRIGHTON, S"

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs by Wang, D, Guo, Y, Wrighton, S A, Cooke, G E, Sadee, W

“…Cytochrome P450 3A4 (CYP3A4) metabolizes ∼50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of…”
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The Influencers: Mentors Can Make a Difference in Your Career by Wrighton, Mark S

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Functional Group Imaging by Chemical Force Microscopy by Frisbie, C. Daniel, Rozsnyai, Lawrence F., Noy, Aleksandr, Wrighton, Mark S., Lieber, Charles M.

“…Mapping the spatial arrangement of chemical functional groups and their interactions is of significant importance to problems ranging from lubrication and…”
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In Vitro Glucuronidation Using Human Liver Microsomes and The Pore-Forming Peptide Alamethicin by FISHER, M. B, CAMPANALE, K, ACKERMANN, B. L, VANDENBRANDEN, M, WRIGHTON, S. A

“…The UDP-glucuronosyltransferases (UGTs) are a superfamily of membrane-bound enzymes whose active site is localized inside the endoplasmic reticulum…”
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Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion by Bhatnagar, Sushant, Soni, Mufaddal S., Wrighton, Lindsay S., Hebert, Alexander S., Zhou, Amber S., Paul, Pradyut K., Gregg, Trillian, Rabaglia, Mary E., Keller, Mark P., Coon, Joshua J., Attie, Alan D.

“…The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn…”
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Efficient Solid-State Photoluminescence in New Poly(2,5-dialkoxy-p-phenyleneethynylene)s by Weder, Christoph, Wrighton, Mark S

“…A series of novel poly(2,5-dialkoxy-p-phenyleneethynylene)s (PPEs) has been prepared by the palladium-catalyzed cross-coupling polycondensaton of aryl…”
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Reopening Colleges and Universities During the COVID-19 Pandemic by Wrighton, Mark S, Lawrence, Steven J

“…Reopening of schools for fall 2020 is a daunting challenge; indeed, zero-risk reopening is not possible. With no effective treatment for victims, no vaccine,…”
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Chemical Force Microscopy: Exploiting Chemically-Modified Tips To Quantify Adhesion, Friction, and Functional Group Distributions in Molecular Assemblies by Noy, Aleksandr, Frisbie, C. Daniel, Rozsnyai, Lawrence F, Wrighton, Mark S, Lieber, Charles M

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THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM by EKINS, SEAN, WRIGHTON, STEVEN A.

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Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors by EKINS, S, BRAVI, G, BINKLEY, S, GILLESPIE, J. S, RING, B. J, WIKEL, J. H, WRIGHTON, S. A

“…The interaction of competitive type inhibitors with the active site of cytochrome P450 (CYP) 2C9 has been predicted using three- and four-dimensional…”
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The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism by Fisher, Michael B., Paine, Mary F., Strelevitz, Timothy J., Wrighton, Steven A.

“…At present, the methods and enzymology of the UDP-glucuronosyltransferases (UGTs) lag behind that of the cytochromes P450 (CYPs). About 15 human UGTs have been…”
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Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities by Dantzig, A H, Shepard, R L, Law, K L, Tabas, L, Pratt, S, Gillespie, J S, Binkley, S N, Kuhfeld, M T, Starling, J J, Wrighton, S A

“…Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers multidrug resistance to tumor…”
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Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test by Lown, K S, Kolars, J C, Thummel, K E, Barnett, J L, Kunze, K L, Wrighton, S A, Watkins, P B

“…The CYP3A subfamily of cytochromes P450 metabolize many medications and environmental contaminants. CYP3A4 and, in 25% of patients, CYP3A5 seem to be the major…”
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Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression by Schuetz, Erin, Kuehl, Peter, Zhang, Jiong, Lin, Yvonne, Lamba, Jatinder, Assem, Mahfoud, Schuetz, John, Watkins, Paul B, Daly, Ann, Wrighton, Steven A, Hall, Stephen D, Maurel, Patrick, Relling, Mary, Brimer, Cynthia, Yasuda, Kazuto, Venkataramanan, Raman, Strom, Stephen, Thummel, Kenneth, Boguski, Mark S

“…Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs…”
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Layer-by-Layer Growth of Electrostatically Assembled Multilayer Porphyrin Films by Araki, Koiti, Wagner, Michael J, Wrighton, Mark S

“…The feasibility of preparing multilayer porphyrin films with monolayer control of composition and thickness is demonstrated. Successive dip-coating of…”
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Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates by Ekins, S, Bravi, G, Wikel, J H, Wrighton, S A

“…To gain a better understanding of the active site of cytochrome P-450 (CYP) 3A4, a three-dimensional-quantitative structure activity relationship model was…”
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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily by Gorski, J C, Hall, S D, Jones, D R, VandenBranden, M, Wrighton, S A

“…The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes containing CYP3A7 to metabolize midazolam were investigated using human…”
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Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey by Sharer, J E, Shipley, L A, Vandenbranden, M R, Binkley, S N, Wrighton, S A

“…The metabolism of probe substrates of phase I and phase II enzymes in vitro were compared in hepatic subcellular fractions from humans, cynomolgus monkeys,…”
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A Novel, Bright Blue Electroluminescent Polymer:  A Diphenylanthracene Derivative by Kim, Yunhi, Kwon, Sunki, Yoo, Dongsik, Rubner, Michael F, Wrighton, Mark S

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Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine by WRIGHTON, S. A, RING, B. J

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