Search Results - "WRIGHT, Jennifer E. I"
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A Dendritic Tetra(bisphosphonic acid) for Improved Targeting of Proteins to Bone
Published in Angewandte Chemie International Edition (13-06-2005)“…Close to the bone: A dendritic molecule that contains four bone‐seeking bisphosphonic acid groups (see picture) has been prepared for targeting proteins to…”
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Improved Bone Delivery of Osteoprotegerin by Bisphosphonate Conjugation in a Rat Model of Osteoarthritis
Published in Molecular pharmaceutics (06-04-2009)“…This study investigated the delivery of a model therapeutic protein, namely, osteoprotegerin (OPG), to bone sites in an animal model of osteoarthritis. The OPG…”
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Cleavage of Disulfide-Linked Fetuin−Bisphosphonate Conjugates with Three Physiological Thiols
Published in Biomacromolecules (01-09-2005)“…An effective therapeutic agent for treatment of bone diseases is expected to exhibit a high affinity to bone. Conjugating proteins to bisphosphonates (BPs), a…”
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Imparting mineral affinity to proteins with thiol-labile disulfide linkages
Published in Journal of biomedical materials research. Part A (15-09-2005)“…Chemical conjugation of bisphosphonates (BPs) to proteins is an effective means to enhance binding of proteins to mineral‐containing biomaterials. BPs linked…”
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The Interaction of Cationic Polymers and Their Bisphosphonate Derivatives with Hydroxyapatite
Published in Macromolecular bioscience (10-05-2007)“…Conjugating proteins with bisphosphonates (BPs), a class of molecules with exceptional affinity to hydroxyapatite (HA), is a feasible means to impart bone…”
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A comparison of mineral affinity of bisphosphonate–protein conjugates constructed with disulfide and thioether linkages
Published in Biomaterials (01-02-2006)“…Chemical conjugation of bisphosphonates (BPs) to therapeutic proteins is an effective means to impart mineral affinity to proteins. Such conjugates can be…”
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Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis
Published in Biochemistry (Easton) (17-06-2003)“…AroA (EPSP synthase) catalyzes carboxyvinyl transfer through addition of shikimate 3-phosphate (S3P) to phosphoenolpyruvate (PEP) to form a tetrahedral…”
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Simulating hydroxyapatite binding of bone-seeking bisphosphonates
Published in Advances in experimental medicine and biology (2004)Get more information
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Electrochemical impedance spectroscopy and quartz crystal nanobalance (EQCN) studies of insulin adsorption on Pt
Published in Journal of electroanalytical chemistry (Lausanne, Switzerland) (15-03-2004)“…The interfacial behaviour of insulin at a Pt surface was studied over the temperature range from 273 to 353 K in a phosphate buffer solution, pH 7.0, using…”
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A Dendritic Tetra(bisphosphonic acid) for Improved Targeting of Proteins to Bone
Published in Angewandte Chemie (13-06-2005)“…Nahe am Knochen: Ein dendritisches Molekül mit vier „Knochen‐philen“ Bisphosphonsäuregruppen (siehe Bild) wurde für das Dirigieren von Proteinen zu…”
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A Dendritic Tetra(bisphosphonic acid) for Improved Targeting of Proteins to Bone
Published in Angewandte Chemie (13-06-2005)Get full text
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