Search Results - "WRAIGHT, C. J"

Insulin-like growth factor binding protein-3 (IGFBP-3) localizes to and modulates proliferative epidermal keratinocytes in vivo by Edmondson, S.R., Thumiger, S.P., Kaur, P., Loh, B., Koelmeyer, R., Li, A., Silha, J.V., Murphy, L.J., Wraight, C.J., Werther, G.A.

“…Summary Background  The colocalization of insulin‐like growth factor binding protein‐3 (IGFBP‐3) and IGF‐I receptor (IGF‐IR) in the basal/germinative layer of…”
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A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice by Tachas, G, Lofthouse, S, Wraight, C J, Baker, B F, Sioufi, N B, Jarres, R A, Berdeja, A, Rao, A M, Kerr, L M, d’Aniello, E M, Waters, M J

“…Diabetic retinopathy and acromegaly are diseases associated with excess action of GH and its effector IGF-I, and there is a need for improved therapies. We…”
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Antisense oligonucleotide treatments for psoriasis by White, P J, Atley, L M, Wraight, C J

“…Antisense oligonucleotides are emerging as an exciting therapeutic strategy for treating skin diseases such as psoriasis. Potential antisense targets are…”
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Intranuclear Localization of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) During Cell Division in Human Keratinocytes by Wraight, Christopher J., Liepe, Ingrid J., White, Paul J., Hibbs, Alan R., Werther, George A.

“…Insulin-like growth factor-I (IGF-I) stimulation of basal keratinocytes is an essential component of normal epidermal homeostasis. In addition to the IGF…”
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Interactions between growth hormone, insulin-like growth factor I, and basic fibroblast growth factor in melanocyte growth by EDMONDSON, S. R, RUSSO, V. C, MCFARLANE, A. C, WRAIGHT, C. J, WERTHER, G. A

“…Melanocytes, highly differentiated neural crest-derived cells, are located in the basal layer of the epidermis, where they play a role in protecting against UV…”
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Human major histocompatibility complex class II invariant chain is expressed on the cell surface by WRAIGHT, C. J, VAN ENDERT, P, MÖLLER, P, LIPP, J, LING, N. R, MACLENNAN, I. C. M, KOCH, N, MOLDENHAUER, G

“…Class II major histocompatibility complex antigens are intracellularly associated with a nonpolymorphic polypeptide referred to as the invariant chain. Before…”
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Live Confocal Microscopy of Oligonucleotide Uptake by Keratinocytes in Human Skin Grafts on Nude Mice by White, Paul J., Fogarty, Rhys D., Liepe, Ingrid J., Werther, George A., Wraight, Christopher J., Delaney, Peter M.

“…Anti-sense oligonucleotide uptake by keratinocytes in human skin grafts on athymic mice was examined using live confocal microscopy. Fluorescein…”
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Calcium Regulates the Expression of Insulin-Like Growth Factor Binding Protein-3 by the Human Keratinocyte Cell Line HaCaT by Edmondson, Stephanie R., Werther, George A., Wraight, Christopher J.

“…The insulin-like growth factor (IGF) system is essential for epidermal homeostasis. Insulin-like growth factor binding protein 3 (IGFBP-3), a modulator of IGF…”
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Oligonucleotide Uptake in Cultured Keratinocytes: Influence of Confluence, Cationic Liposomes, and Keratinocyte Cell Type by White, Paul J., Fogarty, Rhys D., McKean, Sandra C., Venables, Daryl J., Werther, George A., Wraight, Christopher J.

“…The success of anti-sense strategies has been limited, at least in part, by the poor uptake of these agents into the target cells. In keratinocytes, there is…”
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Insulin-Like Growth Factor-I and Epidermal Growth Factor Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Human Keratinocyte Cell Line HaCaT by Wraight, Christopher J., Werther, George A.

“…The human keratinocyte cell line HaCaT has a basal phenotype and secretes an insulin-like growth factor (IGF) binding protein, IGFBP-3, which modulates its…”
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Antisense oligonucleotides in cutaneous therapy by Wraight, Christopher J, White, Paul J

“…Antisense oligonucleotides have been the subject of intense interest as research tools to elucidate the functions of gene products and as therapeutic agents…”
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The effect of pristane on ascites tumor formation and monoclonal antibody production by Hoogenraad, N J, Wraight, C J

“…Preinjection of mice 10 days before intraperitoneal injections of hybridomas gives optimum development of ascites tumors with respect to the rate at which…”
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Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides by Wraight, Christopher J, White, Paul J, McKean, Sandra C, Fogarty, Rhys D, Venables, Daryl J, Liepe, Ingrid J, Edmondson, Stephanie R, Werther, George A

“…Epidermal hyperplasia is a key feature of the common skin disorder psoriasis. Stimulation of epidermal keratinocytes by insulin-like growth factor I (IGF-I) is…”
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Expression of Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) in the Psoriatic Lesion by Wraight, Christopher J., Edmondson, Stephanie R., Fortune, Denys W., Varigos, George, Werther, George A.

“…Epidermal hyper-proliferation is a key feature of psoriasis, and a role for IGF-I in this process has previously been proposed. Herein we investigated the…”
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Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: a model for antisense strategies in keratinocytes by White, P J, Fogarty, R D, Werther, G A, Wraight, C J

“…Antisense strategies targeting skin conditions are attractive in concept, with a number of possible pathologic conditions, such a psoriasis, apparently…”
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A Keratinocyte Cell Line Synthesizes a Predominant Insulin-Like Growth Factor-Binding Protein (IGFBP-3) that Modulates Insulin-Like Growth Factor-I Action by Wraight, Christopher J, Murashita, Mari M, Russo, Vincenzo C, Werther, George A

“…Insulin-like growth factor-I (IGF-I) is an important regulator of epidermal proliferation and has been shown in vitro to be a powerful stimulator of…”
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The Measurement of Aerosol Size Distributions (AMAD) in Buildings on BNFL's Sellafield Site by Kelso, S.M., Wraight, J.C.

“…Cascade centripeters were used to make measurements of aerosol activity size distributions in several buildings involved in the reprocessing of Magnox Nuclear…”
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Identification of insulin-like growth factor binding proteins from cultured human epidermal keratinocytes by Murashita, M M, Russo, V C, Edmondson, S R, Wraight, C J, Werther, G A

“…The role and mechanisms of action of insulin-like growth factors (IGFs) in skin remain unclear. Epidermal keratinocytes possess IGF-I receptors and are…”
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Epidermal Homeostasis: The Role of the Growth Hormone and Insulin-Like Growth Factor Systems by Edmondson, Stephanie R, Thumiger, Susan P, Werther, George A, Wraight, Christopher J

“…GH and IGF-I and -II were first identified by their endocrine activity. Specifically, IGF-I was found to mediate the linear growth-promoting actions of GH. It…”
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Sequence dependence of C5-propynyl-dU,dC-phosphorothioate oligonucleotide inhibition of the human IGF-I receptor: mRNA, protein, and cell growth by Fogarty, Rhys D, McKean, Sandra C, White, Paul J, Atley, Lynne M, Werther, George A, Wraight, Christopher J

“…Human keratinocytes are highly responsive to mitogenic and antiapoptotic signaling by the insulin-like growth factor-I receptor (IGF-IR). IGF-IR…”
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