Search Results - "WOZNEY, JOHN M"

Delivery of bone morphogenetic proteins for orthopedic tissue regeneration by Seeherman, Howard, Wozney, John M.

“…Carriers for bone morphogenetic proteins (BMPs) are used to increase retention of these factors at orthopedic treatment sites for a sufficient period of time…”
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Overview of bone morphogenetic proteins by Wozney, John M

“…A literature review was conducted. To review the discovery of the bone morphogenetic proteins and describe the bone morphogenetic protein products that will or…”
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A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix by Seeherman, Howard J, Berasi, Stephen P, Brown, Christopher T, Martinez, Robert X, Juo, Z Sean, Jelinsky, Scott, Cain, Michael J, Grode, Jaclyn, Tumelty, Kathleen E, Bohner, Marc, Grinberg, Orly, Orr, Nadav, Shoseyov, Oded, Eyckmans, Jeroen, Chen, Christopher, Morales, Pablo R, Wilson, Christopher G, Vanderploeg, Eric J, Wozney, John M

“…Bone morphogenetic protein (BMP)/carriers approved for orthopedic procedures achieve efficacy superior or equivalent to autograft bone. However, required…”
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BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2 by Lee, Mi-Hye, Kwon, Tae-Geon, Park, Hyo-Sang, Wozney, John M, Ryoo, Hyun-Mo

“…BMP-2 stimulates the expression of three osteogenic master transcription factors: Runx2, Dlx5, and Osterix (Osx). However, the hierarchical regulatory…”
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rhBMP-12 Accelerates Healing of Rotator Cuff Repairs in a Sheep Model by Seeherman, Howard J, Archambault, Joanne M, Rodeo, Scott A, Turner, A Simon, Zekas, Lisa, DʼAugusta, Darren, Li, X Jian, Smith, Erica, Wozney, John M

“…BackgroundThe success rate of rotator cuff repairs is variable. This study was performed to evaluate the ability of recombinant human bone morphogenetic…”
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Bone Morphogenetic Protein-2-induced Alkaline Phosphatase Expression Is Stimulated by Dlx5 and Repressed by Msx2 by Kim, Youn-Jeong, Lee, Mi-Hye, Wozney, John M., Cho, Je-Yoel, Ryoo, Hyun-Mo

“…Alkaline phosphatase (ALP) is a widely accepted bone marker. Its expression is stimulated by bone morphogenetic protein (BMP)-2 treatment, the activation of…”
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Delivering on the promise of bone morphogenetic proteins by Li, Rebecca H., Wozney, John M.

“…The advent of bone growth factors has been widely anticipated since their successful production using recombinant DNA technology. Bone morphogenetic proteins…”
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Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects by Jovanovic, Sascha A., Hunt, Dennis R., Bernard, George W., Spiekermann, Hubertus, Wozney, John M., Wikesjö, Ulf M. E.

“…Background: Alveolar ridge aberrations commonly require bone augmentation procedures for optimal placement of endosseous dental implants. The objective of this…”
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Dlx5 Specifically Regulates Runx2 Type II Expression by Binding to Homeodomain-response Elements in the Runx2 Distal Promoter by Lee, Mi-Hye, Kim, Youn-Jeong, Yoon, Won-Joon, Kim, Jee-In, Kim, Byung-Gyu, Hwang, Yoo-Seok, Wozney, John M., Chi, Xin-Zi, Bae, Suk-Chul, Choi, Kang-Young, Cho, Je-Yoel, Choi, Je-Yong, Ryoo, Hyun-Mo

“…Two major isoforms of the Runx2 gene are expressed by alternative promoter usage: Runx2 type I (Runx2-I) is derived from the proximal promoter (P2), and Runx2…”
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Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model by Hall, Jan, Sorensen, Rachel G., Wozney, John M., Wikesjö, Ulf M.E.

“…Background: The objective of this study was to evaluate local bone formation at titanium porous oxide (TPO) implant surfaces adsorbed with recombinant human…”
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Bone formation at recombinant human bone morphogenetic protein-2-coated titanium implants in the posterior mandible (Type II bone) in dogs by Wikesjö, Ulf M. E., Xiropaidis, Andreas V., Qahash, Mohammed, Lim, Won Hee, Sorensen, Rachel G., Rohrer, Michael D., Wozney, John M., Hall, Jan

“…Background: Conventional oral/maxillofacial implants reach osseointegration over several months during which the titanium fixtures interact with alveolar bone…”
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Effect of Recombinant Human Bone Morphogenetic Protein‐2/Absorbable Collagen Sponge (rhBMP‐2/ACS) on Healing in 3‐Wall Intrabony Defects in Dogs by Choi, Seong‐Ho, Kim, Chong‐Kwan, Cho, Kyoo‐Sung, Huh, Ji‐Sun, Sorensen, Rachel G., Wozney, John M., Wikesjö, Ulf M.E.

“…Background: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable collagen sponge (ACS) carrier is being evaluated as a candidate therapy…”
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Bone Repair Following Recombinant Human Bone Morphogenetic Protein‐2 Stimulated Periodontal Regeneration by Selvig, Knut A., Sorensen, Rachel G., Wozney, John M., Wikesjö, Ulf M.E.

“…Background: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) in an absorbable sponge (ACS) carrier is currently being evaluated as candidate therapy…”
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Activation of Bone Remodeling Compartments in BMP-2-Injected Knees Supports a Local Vascular Mechanism for Arthritis-Related Bone Changes by Seeherman, Howard J., Li, X. Jian, Wozney, John M.

“…BACKGROUND:Synovial membrane-derived factors are implicated in arthritis-related bone changes. The route that synovial factors use to access subchondral bone…”
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Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis by Li, Gang, Bouxsein, Mary L, Luppen, Cynthia, Jian Li, X, Wood, Martin, Seeherman, Howard J, Wozney, John M, Simpson, Hamish

“…Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a differentiation factor which has been shown to induce bone formation and heal bony defects in a…”
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Periodontal repair in dogs: evaluation of a bioresorbable calcium phosphate cement (CeredexTM) as a carrier for rhBMP-2 by Sorensen, Rachel G., Wikesjö, Ulf M. E., Kinoshita, Atsuhiro, Wozney, John M.

“…Background: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) has been shown to induce clinically relevant bone formation for orthopedic, craniofacial,…”
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Evaluation of Recombinant Human Bone Morphogenetic Protein‐2 on the Repair of Alveolar Ridge Defects in Baboons by Miranda, Dario A.O., Blumenthal, Neil M., Sorensen, Rachel G., Wozney, John M., Wikesjö, Ulf M.E.

“…Background: The objective of this study was to evaluate alveolar ridge augmentation following surgical implantation of recombinant human bone morphogenetic…”
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A Phase I/II trial of MYO-029 in Adult Subjects with Muscular Dystrophy by WAGNER, Kathryn R, FLECKENSTEIN, James L, EAGLE, Michelle, FLORENCE, Julaine M, KING, Wendy M, PANDYA, Shree, STRAUB, Volker, JUNEAU, Paul, MEYERS, Kathleen, CSIMMA, Cristina, ARAUJO, Tracey, ALLEN, Robert, AMATO, Anthony A, PARSONS, Stephanie A, WOZNEY, John M, LAVALLIE, Edward R, MENDELL, Jerry R, BAROHN, Richard J, BUSHBY, Katharine, ESCOLAR, Diana M, FLANIGAN, Kevin M, PESTRONK, Alan, TAWIL, Rabi, WOLFE, Gil I

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A BMP/Activin A Chimera Induces Posterolateral Spine Fusion in Nonhuman Primates at Lower Concentrations Than BMP-2 by Seeherman, Howard J., Wilson, Christopher G., Vanderploeg, Eric J., Brown, Christopher T., Morales, Pablo R., Fredricks, Douglas C., Wozney, John M.

“…Supraphysiologic bone morphogenetic protein (BMP)-2 concentrations are required to induce spinal fusion. In this study, a BMP-2/BMP-6/activin A chimera…”
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Space-Providing Expanded Polytetrafluoroethylene Devices Define Alveolar Augmentation at Dental Implants Induced by Recombinant Human Bone Morphogenetic Protein 2 in an Absorbable Collagen Sponge Carrier by Wikesjö, Ulf M.E., Qahash, Mohammed, Thomson, Robert C., Cook, Aionzo D., Rohrer, Michael D., Wozney, John M., Hardwick, W. Ross

“…ABSTRACT Background: Surgical implantation of recombinant human bone morphogenetic protein 2 (rhBMP‐2) in an absorbable collagen sponge carrier (ACS)…”
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