Search Results - "WOUTERS, Bradly"

Hypoxia signalling through mTOR and the unfolded protein response in cancer by Wouters, Bradly G, Koritzinsky, Marianne

“…Key Points Cellular responses to hypoxia are mediated by both hypoxia-inducible factor (HIF)-dependent and HIF-independent pathways. Each of these O 2…”
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Molecular targeting of hypoxia in radiotherapy by Rey, Sergio, Schito, Luana, Koritzinsky, Marianne, Wouters, Bradly G.

“…Hypoxia (low O2) is an essential microenvironmental driver of phenotypic diversity in human solid cancers. Hypoxic cancer cells hijack evolutionarily…”
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Hypoxia-activated prodrugs: paths forward in the era of personalised medicine by Hunter, Francis W, Wouters, Bradly G, Wilson, William R

“…Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably using bioreductive (hypoxia-activated) prodrugs that target…”
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Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response by Nagelkerke, Anika, Bussink, Johan, Mujcic, Hilda, Wouters, Bradly G, Lehmann, Steffi, Sweep, Fred C G J, Span, Paul N

“…The hypoxia-inducible factor (HIF)-1 pathway can stimulate tumor cell migration and metastasis. Furthermore, hypoxic tumors are associated with a poor…”
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NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data by WAGGOTT, Daryl, CHU, Kenneth, SHAOMING YIN, WOUTERS, Bradly G, LIU, Fei-Fei, BOUTROS, Paul C

“…The NanoString nCounter Platform is a new and promising technology for measuring nucleic acid abundances. It has several advantages over PCR-based techniques,…”
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A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients by Rodenhizer, Darren, Gaude, Edoardo, Cojocari, Dan, Mahadevan, Radhakrishnan, Frezza, Christian, Wouters, Bradly G., McGuigan, Alison P.

“…The profound metabolic reprogramming that occurs in cancer cells has been investigated primarily in two-dimensional cell cultures, which fail to recapitulate…”
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Tellurophene‐Tagging of Teniposide Facilitates Monitoring by Mass Cytometry by Rana, Rahul, Vellanki, Ravi N., Wouters, Bradly G., Nitz, Mark

“…Target engagement and the biodistribution of exogenously administered small molecules is rarely homogenous. Methods to determine the biodistribution at the…”
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The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress by van Galen, Peter, Kreso, Antonija, Mbong, Nathan, Kent, David G., Fitzmaurice, Timothy, Chambers, Joseph E., Xie, Stephanie, Laurenti, Elisa, Hermans, Karin, Eppert, Kolja, Marciniak, Stefan J., Goodall, Jane C., Green, Anthony R., Wouters, Bradly G., Wienholds, Erno, Dick, John E.

“…Molecular, pharmacological and functional data show that haematopoietic stem cells (HSCs) are predisposed to ER-stress-mediated apoptosis compared to closely…”
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The Roles of Reactive Oxygen Species and Autophagy in Mediating the Tolerance of Tumor Cells to Cycling Hypoxia by Koritzinsky, Marianne, PhD, Wouters, Bradly G., PhD

“…Tumor hypoxia (low oxygenation) causes treatment resistance and poor patient outcome. A substantial fraction of tumor cells experience cycling hypoxia,…”
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PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS by Rouschop, Kasper M., Dubois, Ludwig J., Keulers, Tom G., van den Beucken, Twan, Lambin, Philippe, Bussink, Johan, van der Kogel, Albert J., Koritzinsky, Marianne, Wouters, Bradly G.

“…Hypoxia is a common feature of tumors and an important contributor to malignancy and treatment resistance. The ability of tumor cells to survive hypoxic stress…”
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Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response by ZANNELLA, Vanessa E, DAL PRA, Alan, WOUTERS, Bradly G, BRISTOW, Robert G, KORITZINSKY, Marianne, MUADDI, Hala, MCKEE, Trevor D, STAPLETON, Shawn, SYKES, Jenna, GLICKSMAN, Rachel, CHAIB, Selim, ZAMIARA, Paul, MILOSEVIC, Michael

“…Tumor hypoxia is a negative prognostic factor in multiple cancers, due in part to its role in causing resistance to radiotherapy. Hypoxia arises in tumor…”
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“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways by Koumenis, Constantinos, Wouters, Bradly G

“…Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated with poor prognosis due to the protection it affords to radiotherapy…”
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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5 by Rouschop, Kasper M A, van den Beucken, Twan, Dubois, Ludwig, Niessen, Hanneke, Bussink, Johan, Savelkouls, Kim, Keulers, Tom, Mujcic, Hilda, Landuyt, Willy, Voncken, Jan Willem, Lambin, Philippe, van der Kogel, Albert J, Koritzinsky, Marianne, Wouters, Bradly G

“…Tumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs…”
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MATE2 Expression Is Associated with Cancer Cell Response to Metformin by Chowdhury, Sanjana, Yung, Eric, Pintilie, Melania, Muaddi, Hala, Chaib, Selim, Yeung, ManTek, Fusciello, Manlio, Sykes, Jenna, Pitcher, Bethany, Hagenkort, Anna, McKee, Trevor, Vellanki, Ravi, Chen, Eric, Bristow, Robert G, Wouters, Bradly G, Koritzinsky, Marianne

“…There is great interest in repurposing the commonly prescribed anti-diabetic drug metformin for cancer therapy. Intracellular uptake and retention of metformin…”
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De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models by Huang, Lei, Vellanki, Ravi N, Zhu, Zhiyuan, Wouters, Bradly G, Keshavjee, Shaf, Liu, Mingyao

“…Ex vivo lung perfusion (EVLP) has increased donor lung utilization through assessment of “marginal” lungs prior to transplantation. To develop it as a donor…”
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Two phases of disulfide bond formation have differing requirements for oxygen by Koritzinsky, Marianne, Levitin, Fiana, van den Beucken, Twan, Rumantir, Ryan A, Harding, Nicholas J, Chu, Kenneth C, Boutros, Paul C, Braakman, Ineke, Wouters, Bradly G

“…Most proteins destined for the extracellular space require disulfide bonds for folding and stability. Disulfide bonds are introduced co- and…”
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Regulation of autophagy through multiple independent hypoxic signaling pathways by Rouschop, Kasper M A, Wouters, Bradly G

“…The poorly developed vasculature in solid human tumors is responsible for a profound level of intra- and inter-tumor heterogeneity in oxygen concentration…”
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Hypoxia and Predicting Radiation Response by Hill, Richard P., PhD, Bristow, Robert G., MD, PhD, Fyles, Anthony, MD, Koritzinsky, Marianne, PhD, Milosevic, Michael, MD, Wouters, Bradly G., PhD

“…The results from many studies indicate that most solid tumors, regardless of site of origin, contain hypoxic regions. Experimental studies have demonstrated…”
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Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER by van den Beucken, Twan, Koch, Elizabeth, Chu, Kenneth, Rupaimoole, Rajesha, Prickaerts, Peggy, Adriaens, Michiel, Voncken, Jan Willem, Harris, Adrian L., Buffa, Francesca M., Haider, Syed, Starmans, Maud H. W., Yao, Cindy Q., Ivan, Mircea, Ivan, Cristina, Pecot, Chad V., Boutros, Paul C., Sood, Anil K., Koritzinsky, Marianne, Wouters, Bradly G.

“…MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA…”
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Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy by Rey, Sergio, Schito, Luana, Wouters, Bradly G, Eliasof, Scott, Kerbel, Robert S

“…Hypoxia (low O ) is a pathobiological hallmark of solid cancers, resulting from the imbalance between cellular O consumption and availability. Hypoxic cancer…”
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